DRSC/TRiP Functional Genomics Resources

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Protein Alignment nab and NAB2

DIOPT Version :9

Sequence 1:NP_001014557.3 Gene:nab / 3346237 FlyBaseID:FBgn0259986 Length:625 Species:Drosophila melanogaster
Sequence 2:NP_005958.1 Gene:NAB2 / 4665 HGNCID:7627 Length:525 Species:Homo sapiens


Alignment Length:493 Identity:164/493 - (33%)
Similarity:221/493 - (44%) Gaps:118/493 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 APSASSSPIMSPQGKIFGRNANGTMITTSRPGNEA--------EVQLYRVLQRASLLAYYDTLLE 139
            |||.::.   .|.|.  |.:|..|:....:|...|        |:|||||||||:||:||:|.::
Human     4 APSPTAE---QPPGG--GDSARRTLQPRLKPSARAMALPRTLGELQLYRVLQRANLLSYYETFIQ 63

  Fly   140 MGGDDVQQLYDAGEEEFLEIMALVGMASKPLHVRRLQKALHEWANNPGLFQGPMMPHLGLCETPP 204
            .||||||||.:||||||||||||||||:||||||||||||.|||.|||||..|:           
Human    64 QGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFSQPV----------- 117

  Fly   205 KPALIFNPDTTPALPRQKFPSF--------------NPSGSSFMPSPVPPAPLPASASVPAPTVP 255
                       ||:|....|.|              |..||        |.....||...:|..|
Human   118 -----------PAVPVSSIPLFKISETAGTRKGSMSNGHGS--------PGEKAGSARSFSPKSP 163

  Fly   256 --LATQIS-CPSAPSVPLPLVLPPNPLTSSPH-----------------PSANSNLPANT----- 295
              |..::| .|..|....|.:.|..   |:|.                 |.|...:|..|     
Human   164 LELGEKLSPLPGGPGAGDPRIWPGR---STPESDVGAGGEEEAGSPPFSPPAGGGVPEGTGAGGL 225

  Fly   296 -AHQVSSSSPQLTPVLTEAQIQRITMCADKIGRQLPQREPRAQTT----RKRTTRELEQVIAMGE 355
             |........:|.|.:....::.:    ::|.|..|:.:....|:    .|:..|.:..:..|.:
Human   226 AAGGTGGGPDRLEPEMVRMVVESV----ERIFRSFPRGDAGEVTSLLKLNKKLARSVGHIFEMDD 286

  Fly   356 QDPRRMDEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQLCRNPQTIWLLTRRDELFPLARQ 420
            .|.::.:||||||.||||||.|||..|.|:|||:.:||||||.|....|  ||.||.|||.|:||
Human   287 NDSQKEEEIRKYSIIYGRFDSKRREGKQLSLHELTINEAAAQFCMRDNT--LLLRRVELFSLSRQ 349

  Fly   421 IVKDAGFGHSASIAR-----YGG-----LLTQLPSQGAGLGGGRAPGDTDCESSDAAVPSKRQRL 475
            :.:::.:..|...:|     .||     |..::..|.........||      .::.||..|..|
Human   350 VARESTYLSSLKGSRLHPEELGGPPLKKLKQEVGEQSHPEIQQPPPG------PESYVPPYRPSL 408

  Fly   476 SSTEAAQLPLDLNREAVEDSRYNLFAMYQKFAKPPFDL 513
            ....|:     |:.|:: |..........:...||.||
Human   409 EEDSAS-----LSGESL-DGHLQAVGSCPRLTPPPADL 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nabNP_001014557.3 NCD1 113..190 CDD:282724 60/84 (71%)
NCD2 301..435 CDD:282725 49/137 (36%)
NAB2NP_005958.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 7/22 (32%)
NCD1 35..113 57/77 (74%)
NCD1 36..114 CDD:398528 58/77 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 135..237 21/112 (19%)
NCD2 237..363 CDD:398529 49/131 (37%)
NCD2 267..356 42/90 (47%)
Necessary for nuclear localization. /evidence=ECO:0000250 353..384 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..416 8/46 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..525
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160059
Domainoid 1 1.000 126 1.000 Domainoid score I5425
eggNOG 1 0.900 - - E1_KOG3835
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 205 1.000 Inparanoid score I3727
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1002244at2759
OrthoFinder 1 1.000 - - FOG0002990
OrthoInspector 1 1.000 - - otm40599
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12623
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3887
SonicParanoid 1 1.000 - - X1985
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.890

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