DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nab and nab1

DIOPT Version :9

Sequence 1:	NP_001014557.3	Gene:	nab / 3346237	FlyBaseID:	FBgn0259986	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001120223.1	Gene:	nab1 / 100145272	XenbaseID:	XB-GENE-1013984	Length:	455	Species:	Xenopus tropicalis

Alignment Length:	479	Identity:	160/479 - (33%)
Similarity:	230/479 - (48%)	Gaps:	103/479 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 ITTSRPGNEAEVQLYRVLQRASLLAYYDTLLEMGGDDVQQLYDAGEEEFLEIMALVGMASKPLHV 172
            :.:|.|....|:||||:||||:||:|:|..::.||||||||.:||||||||||||||||||||||
Frog     1 MASSLPRTLGELQLYRILQRANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHV 65

  Fly   173 RRLQKALHEWANNPGLFQGPMMPHLGLCETPPKPALIFNPDTTPALPRQKFPSFNP------SGS 231
            |||||||.:|..|||:|..|:            .:|.|:     ::|..|.|..:.      |.|
Frog    66 RRLQKALRDWVTNPGIFNQPL------------TSLPFS-----SIPIYKLPESSSALLGINSNS 113

  Fly   232 SFMPSPV--PPAPLPASASVPAPTVPLATQISCPSAPSVPLPLVLPPNPLTSS-------PHPSA 287
            |.|.|..  |...:|..|         ||.: ||....     |:..:||.::       .|.:.
Frog   114 SEMKSNTRDPHLKIPKCA---------ATTL-CPGKSD-----VVGNSPLQNNSEGRHWQSHHTT 163

  Fly   288 NSNLPANTAHQVSSSSPQ-LTPVLTEAQIQRITMCADKIGRQLPQREPRA----QTTRKRTTREL 347
            .|....:.|...|.:||: :|..|..:....:..|.:::...||:.:...    ..|.|:.::.:
Frog   164 ESEHSLSPADLGSPASPRDITETLDTSAALSVAECVERMFPSLPKSDVNEVREFLKTNKKLSKMI 228

  Fly   348 EQVIAMGEQDPRRMDEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQLCRNPQTIWLLTRRD 412
            ..:..|.::||.|.:|||||||||||||.||:..|.|||||:.|||||||||.  :.|.||||||
Frog   229 GHIFEMVDEDPHREEEIRKYSAIYGRFDSKRKDGKHLTLHELTVNEAAAQLCM--KDIALLTRRD 291

  Fly   413 ELFPLARQIVKDAGFGHSASIARYGGLLTQLPSQGAGLGGGRAPGDTDCESSDAAVPSK---RQR 474
            |||.|||||.::..:.::....:                       :.||..:...|.:   .:.
Frog   292 ELFTLARQISREVTYKYTYRSTK-----------------------SKCEDREELSPKRIKTEEN 333

  Fly   475 LSSTEAAQLPLDLNREAVEDS------------RYNLFAMYQKFAKPPFDL-----------SEI 516
            :|..:...|.|....|::::.            .::|.|..:|......|:           .||
Frog   334 ISDYQGTHLTLHQQMESLKEQMAIAKAKGEETVAHSLQAKLEKLLSKQLDILRNSEYDRLQNPEI 398

  Fly   517 AKFSVSKAADYEDNDSRFSFSNSS 540
            ..||.....:.|:|......|:||
Frog   399 CHFSGHYLKNLENNSPTTIASDSS 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nab	NP_001014557.3	NCD1	113..190	CDD:282724	55/76 (72%)
nab	NP_001014557.3	NCD2	301..435	CDD:282725	58/138 (42%)
nab1	NP_001120223.1	NCD1	6..83	CDD:282724	55/76 (72%)
		NCD2	170..314	CDD:282725	60/145 (41%)
		Nab1	320..454	CDD:282723	18/103 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5521
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3577
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1002244at2759
OrthoFinder	1	1.000	-	-		FOG0002990
OrthoInspector	1	1.000	-	-		otm47774
Panther	1	1.100	-	-	O	PTHR12623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3887
SonicParanoid	1	1.000	-	-		X1985
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100