DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scaf6 and cherp

DIOPT Version :9

Sequence 1:	NP_001014589.1	Gene:	scaf6 / 3346235	FlyBaseID:	FBgn0261872	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	XP_012816162.1	Gene:	cherp / 496512	XenbaseID:	XB-GENE-996440	Length:	955	Species:	Xenopus tropicalis

Alignment Length:	1104	Identity:	356/1104 - (32%)
Similarity:	483/1104 - (43%)	Gaps:	331/1104 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PPRDASLRNIIDKLAEFVARNGPEFEAITKQKQQNNPKFEFLYGGEFANYYQFRVAAEQ------ 63
            ||.|..|||:|||||:||||||||||.:|.:||::||||.||:||||.|||:.::|.||
Frog     6 PPEDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYNYYKCKLAMEQQQYICF 70

  Fly    64 --ALLKQQAINQQLPPGAPSGHYMQHP--PPMQQSQPPGLYPPPNQQPPHPPETAQDNMQQQTQH 124
              .:|.:||  |.:.|.|      |.|  ||.....||.|.|||...||
Frog    71 SHTVLCKQA--QDMEPKA------QIPTIPPPALPLPPTLVPPPQGAPP---------------- 111

  Fly   125 SWPPNSGNGGPPNNQQANGNPMAMNLTSQLEAIKMQQKSLREQIQQSEANLSAQHTALMNQKTKQ 189
                                                   :.:.||||:.|...|...|::.:.:|
Frog   112 ---------------------------------------IDDLIQQSQWNFQQQEQQLLSLRQEQ 137

  Fly   190 IEDAIAAAQTAQQEQMAGEQGIVLRDFDGVLQPIIESCTKDSISAGKNWILQHSTDSAKINVVLQ 254
            :..|:|.|...|.:::..|..:.:.:||.:|||||::||||:||.||||:..::.......::..
Frog   138 VTAAVAHAVEQQMQKLREETQLDMTEFDNLLQPIIDTCTKDAISGGKNWMFSNAKSPQHCELMAG 202

  Fly   255 YLLKKALVNGSTFQQKLHLIYLVNDILHHCMRKNINDLKNSLENVVIPMFCSADLIGNPDQRQKL 319
            :|..:....|:.|:.:||||||:||:||||.||...||..:|:.||:|::|::.|....|::||:
Frog   203 HLRNRITAEGARFELRLHLIYLINDVLHHCQRKQARDLLAALQKVVVPIYCTSFLAVEEDKQQKI 267

  Fly   320 AKLLSLWESKAKFFDACVISKLQSPDSSMQEYKTNLQNTHHDITAKFTQNTKATLDNYQKQHHVF 384
            |:||.||| |..:||...|.:||||...:.:::..|...:..:........:..|...:.||..|
Frog   268 ARLLQLWE-KNGYFDEATILQLQSPALGLGQHQAALLTEYSSMVQPVLVAFQQQLQTLKTQHEEF 331

  Fly   385 IQHASQQIVQLE----------------------------------------------------- 396
            :....||..|::
Frog   332 VTGLKQQQQQIQIPVMEPIPETPAPAPAPTPVPVPMPVPVPPPPEEVKPAMTIPAPAEFEPPPAP 396

  Fly   397 ---------------KQAQHL------EQQIVAQKSQQQHMLQHQQKNIPSLMSHRIAMP----- 435
                           :|..|.      :.|.:|...|||..   :|...|    |..|.|
Frog   397 VPDPAAGGGRGPPPHEQIPHNKPPWFDQPQPIAPWGQQQPC---EQPPFP----HHPAPPHCPPW 454

  Fly   436 -GDHEHMNSQGPHDQQHPQAGNNMYPGGNFQQQQPPPGNHFADP--------------------- 478
             ..||.|    .::|:.|...|...|..| .|::||..|.|..|
Frog   455 SNSHEGM----WNEQRDPNWNNEPEPAWN-NQREPPWNNQFDAPWSNQHEQPPWGGGGGGGGGGG 514

  Fly   479 ----------RGPNFFIPDMSKPPPGFPGPM-HHNQGPAMGQQQPQP---GQFPP--MQAPGSGN 527
                      |.|:|    ..:.||.|.||. .|.|.|....|.|.|   .:|||  ||.    .
Frog   515 GGGGGGGGGQRDPHF----RMQRPPHFRGPFPPHQQHPPQFNQPPHPHNFNRFPPHFMQE----E 571

  Fly   528 EPPVDLGVLSAAIQACLQMQQQHHP---------------DDPQQQG-QHQLQQQQQQQPQQQKQ 576
            .||                   .||               |.|...| .|..|..:...|...:.
Frog   572 FPP-------------------RHPFERPPFPHRFDFPQGDFPADMGPPHHHQGHRMPHPNMNEH 617

  Fly   577 PPPMAAYPQNIVRPGQQNADSSEVDLDVLNAAIRAVITNKPEDGTLEDGQQPQKLVDGESGEP-V 640
            ||          ..|.|:.|                 ...|..|.  :||.|..   ...|.| :
Frog   618 PP----------WGGPQHPD-----------------FGPPPHGF--NGQPPHM---RRQGPPHI 650

  Fly   641 VIGEPQ-IPTAPYYDLPAGLMVPLIRLEDYNYKALDPADIRLPAPAPQSERLTNALNAFYSAPSH 704
            ...:|. :|..||:|||||||.||::|||:.||.|||.|||||.|.|.||||..|:.||||.|||
Frog   651 NHDDPSLVPNVPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSH 715

  Fly   705 DRPRDNEGWEKLGLYEYYKVKNAARKQKEEEIKDGIREKSRSPSPIVLEKPLPKKSNKRVYRSKS 769
            ||||::||||:.||||:::.|..||::|.::.::....:|||.|         |...:...||.|
Frog   716 DRPRNSEGWEQNGLYEFFRAKMRARRRKGQDKRNSRPSRSRSRS---------KSRGQSSSRSNS 771

  Fly   770 RSRSRSKTPPHRDRSLSRSRSRSRSMERSLTPPPMNRSRLGGGNNRKGRNRSPR-HERDNNSGST 833
            ||.|||.:     ||.|||||||||..||       |||      .:.|:||.| |.|
Frog   772 RSSSRSYS-----RSRSRSRSRSRSYSRS-------RSR------SRSRSRSSRSHSR------- 811

  Fly   834 NTREGRGDRGNSNSRDNGNSTNLRRVDRDRSLTPPSF--LGSTFAKPADFIE--ESNKGHQMLMK 894
                       |.||....|...||..|.||.||||.  |||..|.|...:.  |.|||||||:|
Frog   812 -----------SRSRSKSFSPGRRRRSRSRSATPPSSSGLGSGPAGPVPNVRLGEENKGHQMLVK 865

  Fly   895 MGWAGTGTGLGSKNQGIDTPISGGEVRDRREMYKGVGANMHDPFESFRKNKGAAFAHRMRSRDD 958
            |||:|.| |||:..|||..||.||::||:.:.|||||.::.||:|::|:||..:|..||::||:
Frog   866 MGWSGAG-GLGANEQGIQDPIKGGDIRDKWDQYKGVGVSLDDPYENYRRNKSYSFIARMKARDE 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scaf6	NP_001014589.1	Surp	13..61	CDD:280053	32/47 (68%)
		CTD_bind	271..329	CDD:282648	31/57 (54%)
		G-patch	885..933	CDD:279867	30/47 (64%)
cherp	XP_012816162.1	SWAP	13..65	CDD:197818	35/51 (69%)
		CTD_bind	218..280	CDD:368137	32/62 (52%)
		PAT1	<530..>655	CDD:370676	38/179 (21%)
		G-patch	856..901	CDD:366717	28/45 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3688
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1385
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	1	1.000	-	-		FOG0006072
OrthoInspector	1	1.000	-	-		oto104973
Panther	1	1.100	-	-	LDO	PTHR12323
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4367
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160