DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scaf6 and Sf3a1

DIOPT Version :9

Sequence 1:	NP_001014589.1	Gene:	scaf6 / 3346235	FlyBaseID:	FBgn0261872	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001100705.1	Gene:	Sf3a1 / 305479	RGDID:	1311477	Length:	791	Species:	Rattus norvegicus

Alignment Length:	899	Identity:	175/899 - (19%)
Similarity:	277/899 - (30%)	Gaps:	357/899 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VQPPRDASLRNIIDKLAEFVARNGPEFEAITKQKQQNNPKFEFLYGGE-FANYYQFRVA------ 60
            :.||.:  :|||:||.|.|||||||||||..:|.:.|||||.||...: :..||:.:|:
  Rat    43 IYPPPE--VRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKEGK 105

  Fly    61 AEQ---ALLK-----QQAINQQLPPGAPSGHYMQHPPPMQQSQPPGLYPPPNQQPPHPPETAQDN 117
            |::   |:.|     |||..||||....:       ..:|::..|...||..:....||..:..:
  Rat   106 AQEPSAAIPKVMQQQQQATQQQLPQKVQA-------QVIQETIVPKEPPPEFEFIADPPSISAFD 163

  Fly   118 MQQQTQHSWPPNSGNGGPPNNQQANGNPMAMNLTSQLEAIKMQQKSLREQIQQSEAN-----LSA 177
            :.                           .:.||:|..| :..::.|.:.:|:.:.|     |..
  Rat   164 LD---------------------------VVKLTAQFVA-RNGRQFLTQLMQKEQRNYQFDFLRP 200

  Fly   178 QHTALMNQKTKQIEDAIAAAQTAQQEQMAGEQGIVLRDFDGVLQPIIESCTKDSISAGKNWILQH 242
            || :|.|..||.:|                       .:..:|.|            .|....:.
  Rat   201 QH-SLFNYFTKLVE-----------------------QYTKILIP------------PKGLFAKL 229

  Fly   243 STDSAKINVVLQYLLKKALVNGSTFQQKLHLIYLVNDILHHCMRKNINDLKNSLENVVIPMFCSA 307
            ..::.....||..:..:  |..:.||::              .||...:.|.. |.|........
  Rat   230 KKEAENPREVLDQVCYR--VEWAKFQER--------------ERKKEEEEKEK-ERVAYAQIDWH 277

  Fly   308 DLI------------GN---PDQRQKLAKLLSLWESKAKFFDACVISKLQSPDSSMQEYKTNLQN 357
            |.:            ||   |...::|...:.:.|...||.::             :|.:..:::
  Rat   278 DFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGES-------------EEVEMEVES 329

  Fly   358 THHDITAKFTQNTKATLDNYQKQHHVFIQHASQQIVQLEKQAQHLEQQIVAQKSQQQHMLQHQQK 422
            ...|  .:.|:.|.:.||                                 |.:|.|.|
  Rat   330 DEED--QEKTEETPSQLD---------------------------------QDTQVQDM------ 353

  Fly   423 NIPSLMSHRIAMPGDHEHMNSQGPHDQQHPQAGNNMYPGGNFQQQQPPPGNHFADPRGP------ 481
                                .:|..|::..            |:..|||......|..|
  Rat   354 --------------------DEGSDDEEEG------------QKVPPPPETPMPPPLPPTPDQVI 386

  Fly   482 --NFFIPDMSKPPPGFPGPMHHNQGPAMGQQQP--------QPGQFPP----------------- 519
              ..:.|..|||.|..|.|..:...|..|::.|        :.|...|
  Rat   387 VRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDD 451

  Fly   520 -MQAPGSGNEPPVD---------LGVLSAAIQACLQMQQQHHPDD-------------PQQQGQH 561
             :.|||...|..:.         .||...||...:..::...|::             .||..|.
  Rat   452 EVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQA 516

  Fly   562 QLQQQQQ----------------------QQPQQ--QKQPPPMAAYPQNIVRPGQQNADSSEVDL 602
            .:..|:|                      .:|.:  |:.|||.:|          .|..||
  Rat   517 NITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQQPPPPSSA----------TNIPSS---- 567

  Fly   603 DVLNAAIRAVITNKPEDGTLEDGQQPQKLVDGESGEPVVIGEPQIPTAPYYDLPAGLMV----PL 663
                   ...||:.|....:    .|.......|..||:   |:.|.|....||.|.::    |:
  Rat   568 -------APPITSVPRPPAM----PPPVRTTVVSAVPVM---PRPPMASVVRLPPGSVIAPMPPI 618

  Fly   664 IRLEDYNYKALDPA--DIRLPAPAPQSERLTNALNAFYSAPS-------------H-DRPRDNEG 712
            |.....|...:.||  .|..|.|.|..     ...||..||.             | ..|.::|.
  Rat   619 IHAPRINVVPMPPAAPPIMAPRPPPMI-----VPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEP 678

  Fly   713 WEKLGLYEYYKVKNAARKQKEEEIKDGIREKSRSPSPIVLEKPLPKKSNKRVYR 766
            ..|       |:|.......|||.   :|   |:..|:.::..:|...:|..::
  Rat   679 PSK-------KLKTEDSLMPEEEF---LR---RNKGPVSIKVQVPNMQDKTEWK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scaf6	NP_001014589.1	Surp	13..61	CDD:280053	27/54 (50%)
		CTD_bind	271..329	CDD:282648	11/72 (15%)
		G-patch	885..933	CDD:279867
Sf3a1	NP_001100705.1	SWAP	50..103	CDD:197818	28/52 (54%)
		Surp	165..215	CDD:280053	15/101 (15%)
		PRP21_like_P	229..469	CDD:289034	52/342 (15%)
		SF3a120_C	716..791	CDD:176395	0/4 (0%)
		UBQ	716..784	CDD:214563	0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0007
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910