DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scaf6 and tag-65

DIOPT Version :9

Sequence 1:	NP_001014589.1	Gene:	scaf6 / 3346235	FlyBaseID:	FBgn0261872	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_506386.1	Gene:	tag-65 / 179857	WormBaseID:	WBGene00006442	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	888	Identity:	204/888 - (22%)
Similarity:	315/888 - (35%)	Gaps:	288/888 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 TQH--SWPPNSGN-----GGPPNNQQANGNPMAMNLTSQLEAIKMQQK--SLREQIQQSEANLSA 177
            :||  ||  .||:     ..||..:|:     ..:|....|.::.::|  .||::|..||.||:|
Worm    13 SQHGQSW--RSGDIPLPRDFPPPERQS-----IPSLMDPPEIVEWRKKIDELRQKIIDSEQNLNA 70

  Fly   178 QHTALMNQKTKQIEDAIAAAQTAQQEQMAGEQGIVLRDFDGVLQPI-IESCTKDSISAGKNWILQ 241
            ....:.......::.||..::|.:.|:|..:..:.:.|.:..|..: ...|:||.||..|.||.:
Worm    71 HRNGMDELLMAHLKSAIRTSETMKIEKMLSQNNLNVEDLNSYLDAMATPKCSKDLISQAKKWIFE 135

  Fly   242 HSTDSAKINVVLQYLLKKALVNGSTFQQKLHLIYLVNDILHHCMRKNINDLKNSLENVVIPMFC- 305
            :.|......::|.:||.|.....|....:||::||:||...||.||...:....|...|..|:.
Worm   136 YCTSDQLREIILSFLLNKVKDEASGEYLRLHILYLINDWAFHCQRKKEENQMKMLARYVPKMYAY 200

  Fly   306 SADLIGNPDQRQKL-AKLLSLWESKAKFFDACVISKLQSPDSSMQEYKTNLQNTHHDITAKFTQN 369
            ..:|..:.:...|| .|||..||.:..|.|: |..:|::....:...:...::::..|......|
Worm   201 CIELSSSSELSNKLEGKLLGEWEGRQYFADS-VFKQLRNTVQIVSTDREIEKSSYGTIRESIRSN 264

  Fly   370 TKATLDNYQKQHHVFIQHASQQIVQLEKQAQHLEQQIVAQKSQQQHMLQHQQKNIPSLMSHRIAM 434
            ..||.|.|::||..:.||..:||.::|::..
Worm   265 LMATFDGYEQQHVTYSQHIQRQIDEVERKID---------------------------------- 295

  Fly   435 PGDHEHMNSQGPHDQQHPQAGNNMYPGGNFQQQQPPPGNHFADPRGPNFFIPDMSKPPPGFPGPM 499
              :..|..|.||                                                   ..
Worm   296 --EFRHGPSSGP---------------------------------------------------AS 307

  Fly   500 HHNQGPAMGQQQPQPGQFPPMQAPGSGNEPPVDLGVLSAAIQACLQMQQQHHPDDPQQQGQHQLQ 564
            ||...|....::.:..|.|                              :|..:.|.....:...
Worm   308 HHPNAPLSNMRRSRFDQAP------------------------------KHSAERPHASVSNTWN 342

  Fly   565 QQQQQQPQQQKQPPPMAAYPQNIVRPGQQNADSSEVDLDVLNAAIRAVITNKPEDGTLEDGQQPQ 629
            |..||.                         |..::|             ..|.|   |:..:||
Worm   343 QNDQQD-------------------------DGEDID-------------GMPFD---EENLKPQ 366

  Fly   630 KLVDGESGEPVVIGEPQIPTAPYYDLPAGLMVPLIRLEDYNYKALDPADIRLPAPAPQSERLTNA 694
            |                    .|..||||:|.||:.:....|:.|||.::.:||..|.|.||..|
Worm   367 K--------------------SYMALPAGIMTPLVSMNSVMYEPLDPEELEMPASVPPSSRLLAA 411

  Fly   695 LNAFYSAPSHD------------------------RPRDNEGWE---KLGLYEYYKVKNAA---- 728
            .|.|:.....|                        :.|..:.:|   |..:.|:...:.:|
Worm   412 KNMFHKGVEMDIALADGAITEDPTNLKYPLEFLEEKARIKKTFEEKQKCSVEEFITNRPSATDRE 476

  Fly   729 -----RKQKEEEIKDGIRE------KSRSPSPIVLEKPLPKKSNKRV---YRSKSRSRSRSKTPP 779
                 ||.|||:..:.||:      .|:.|...:.|....::||.|.   ...:|||.|||.:|.
Worm   477 RFDKTRKLKEEDQIEKIRKCVDAYYASQEPPENLREDSEARRSNSRSPPRDHKRSRSPSRSPSPR 541

  Fly   780 HRDRSLSRSRSRSRSMERSLTPPPMNRSRLGGGNNRKGRNRSPRHERDNNSGSTNTREGRGDRGN 844
            .|.||.|.|...|.|..||               :...|..||...||:|.|    :.|.|..|.
Worm   542 RRQRSSSNSSRSSGSSSRS---------------SSSSRKSSPERGRDSNIG----QRGYGGGGF 587

  Fly   845 SNSRDNGNSTNLRRVDRDRSLTPPSFLGSTFAKPADFIEESNKGHQMLMKMGWAGTGTGLGSKNQ 909
            |..                    |||...:..:|..:   .|||.|::.||||.  |.|||:...
Worm   588 SER--------------------PSFGFKSAQEPLSY---DNKGAQLMAKMGWG--GKGLGANES 627

  Fly   910 GIDTPISGGEVRDRREMYKGVGANMHDPFESFRKNKGAAFAHR 952
            ||..|:||||||:|.|.:.|:|.:: ||:|.|||.:...:..|
Worm   628 GIVDPVSGGEVRNRNEQFMGLGRSL-DPYEQFRKQRSGTYHDR 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scaf6	NP_001014589.1	Surp	13..61	CDD:280053
		CTD_bind	271..329	CDD:282648	21/59 (36%)
		G-patch	885..933	CDD:279867	25/47 (53%)
tag-65	NP_506386.1	CTD_bind	165..226	CDD:282648	21/60 (35%)
tag-65	NP_506386.1	G_patch	602..649	CDD:197727	24/51 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167661
Domainoid	1	1.000	101	1.000	Domainoid score	I4353
eggNOG	1	0.900	-	-		E1_KOG4368
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	231	1.000	Inparanoid score	I2186
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48532
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	1	1.000	-	-		FOG0006072
OrthoInspector	1	1.000	-	-		oto20468
orthoMCL	1	0.900	-	-		OOG6_108174
Panther	1	1.100	-	-	LDO	PTHR12323
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3181
SonicParanoid	1	1.000	-	-		X4367
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.840