Protein Alignment scaf6 and CHERP

DIOPT Version :9

• Sequence 1: NP_001014589.1
• Gene: scaf6 / 3346235
• FlyBaseID: FBgn0261872
• Length: 960
• Species: Drosophila melanogaster
• Sequence 2: NP_006378.3
• Gene: CHERP / 10523
• HGNCID: 16930
• Length: 916
• Species: Homo sapiens
• Alignment Length: 1075
• Identity: 363/1075 - (33%)
• Similarity: 494/1075 - (45%)
• Gaps: 287/1075 - (26%)

  Fly     5 PPRDASLRNIIDKLAEFVARNGPEFEAITKQKQQNNPKFEFLYGGEFANYYQFRVAAEQALLKQQ 69
            ||.|..|||:|||||:||||||||||.:|.:||::||||.||:||||.:||:.::|.||    ||
Human     6 PPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQ----QQ 66

  Fly    70 AINQQLPPGAPSGHYMQHPPPMQQSQPPGLYP----PPNQQPPHPPETAQDNMQQQTQHSWPPNS 130
            .|.:|                    |.|.|.|    ||..|||..|....
Human    67 LICKQ--------------------QTPELEPAATMPPLPQPPLAPAAPI--------------- 96

  Fly   131 GNGGPPNNQQANGNPMAMNLTSQLEAIKMQQKSLREQIQQSEANLSAQHTALMNQKTKQIEDAIA 195
                ||    |.|.|                 |:.|.||||:.||..|...|:..:.:|:..|:|
Human    97 ----PP----AQGAP-----------------SMDELIQQSQWNLQQQEQHLLALRQEQVTAAVA 136

  Fly   196 AAQTAQQEQMAGEQGIVLRDFDGVLQPIIESCTKDSISAGKNWILQHSTDSAKINVVLQYLLKKA 260
            .|...|.:::..|..:.:.:||.:|||||::||||:|||||||:..::.......::..:|..:.
Human   137 HAVEQQMQKLLEETQLDMNEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRI 201

  Fly   261 LVNGSTFQQKLHLIYLVNDILHHCMRKNINDLKNSLENVVIPMFCSADLIGNPDQRQKLAKLLSL 325
            ..:|:.|:.:||||||:||:||||.||...:|..:|:.||:|::|::.|....|::||:|:||.|
Human   202 TADGAHFELRLHLIYLINDVLHHCQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQL 266

  Fly   326 WESKAKFFDACVISKLQSPDSSMQEYKTNLQNTHHDITAKFTQNTKATLDNYQKQHHVFIQHASQ 390
            || |..:||..:|.:||||...:.:|:..|.|.:..:........:..:...:.||..|:...:|
Human   267 WE-KNGYFDDSIIQQLQSPALGLGQYQATLINEYSSVVQPVQLAFQQQIQTLKTQHEEFVTSLAQ 330

  Fly   391 QIVQLEKQAQHLEQQIVAQKSQQQHMLQHQQKNI--------------------------PSLMS 429
            |            ||   |:.|||..||..|...                          |....
Human   331 Q------------QQ---QQQQQQQQLQMPQMEAEVKATPPPPAPPPAPAPAPAIPPTTQPDDSK 380

  Fly   430 HRIAMPGDHEH-------------MNSQGPHDQ---QHPQAGNNMYPGGNFQQQQP--------- 469
            ..|.|||..|:             ....|||||   ..|...:..:|...:.||||
Human   381 PPIQMPGSSEYEAPGGVQDPAAAGPRGPGPHDQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHH 445

  Fly   470 -------PPGNH-----FADPRG-PNF----FIPDMSKPPPG----FPGPMH--HNQGPAMGQQQ 511
                   ||.|:     :.:.|| |.:    ..|..::|...    |.||.:  |.|.|..|.|:
Human   446 QGGPPHCPPWNNSHEGMWGEQRGDPGWNGQRDAPWNNQPDAAWNSQFEGPWNSQHEQPPWGGGQR 510

  Fly   512 PQP----------GQFPPMQAPGSGNEPPVDLGVLSAAIQACLQMQQQHHPDDPQQQGQHQLQQ- 565
            ..|          |.|||.|.....|:||                    ||        |...:
Human   511 EPPFRMQRPPHFRGPFPPHQQHPQFNQPP--------------------HP--------HNFNRF 547

  Fly   566 -----QQQQQPQQQKQPPPMAAYPQNIVRPGQQNADSSEVDLDVLNAAIRAVITNKPEDGTLED- 624
                 |....|:...:.||   ||.....|  |....:|:.....:...|     .|..|..|.
Human   548 PPRFMQDDFPPRHPFERPP---YPHRFDYP--QGDFPAEMGPPHHHPGHR-----MPHPGINEHP 602

  Fly   625 ----------GQQPQKLVDGESGEPVVI---GEPQI--------PTAPYYDLPAGLMVPLIRLED 668
                      |..|.    |.:|:|..:   |.|.|        |..||:|||||||.||::|||
Human   603 PWAGPQHPDFGPPPH----GFNGQPPHMRRQGPPHINHDDPSLVPNVPYFDLPAGLMAPLVKLED 663

  Fly   669 YNYKALDPADIRLPAPAPQSERLTNALNAFYSAPSHDRPRDNEGWEKLGLYEYYKVKNAARKQKE 733
            :.||.|||.|||||.|.|.||||..|:.||||.|||||||::||||:.||||:::.|..||::|.
Human   664 HEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKG 728

  Fly   734 EEIKDGIREKSRSPSPIVLEKPLPKKSNKRVYRSKSRSRSRSKTPPHRDRSL-SRSRSRSRSMER 797
            :|.::....:|||                   |||||.||.|::.....:|. |.|||||||..|
Human   729 QEKRNSGPSRSRS-------------------RSKSRGRSSSRSNSRSSKSSGSYSRSRSRSCSR 774

  Fly   798 SLTPPPMNRSRLGGGNNRKGRNRSPRHERDNNSGSTNTREGRGDRGNSNSRDNGNSTNLRRVDRD 862
            |.:               :.|:||....|.:.|.|         |..|.||....|...||..|.
Human   775 SYS---------------RSRSRSRSRSRSSRSRS---------RSQSRSRSKSYSPGRRRRSRS 815

  Fly   863 RSLTPPSF--LGSTFAKPA--DFIEESNKGHQMLMKMGWAGTGTGLGSKNQGIDTPISGGEVRDR 923
            ||.||||.  |||..|.|.  ..:.|.|||||||:||||:|:| |||:|.|||..||.||:|||:
Human   816 RSPTPPSSAGLGSNSAPPIPDSRLGEENKGHQMLVKMGWSGSG-GLGAKEQGIQDPIKGGDVRDK 879

  Fly   924 REMYKGVGANMHDPFESFRKNKGAAFAHRMRSRDD 958
            .:.|||||..:.||:|::|:||..:|..||::||:
Human   880 WDQYKGVGVALDDPYENYRRNKSYSFIARMKARDE 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scaf6	NP_001014589.1	Surp	13..61	CDD:280053	31/47 (66%)
		CTD_bind	271..329	CDD:282648	30/57 (53%)
		G-patch	885..933	CDD:279867	32/47 (68%)
CHERP	NP_006378.3	SWAP	13..65	CDD:197818	35/55 (64%)
		SURP motif. /evidence=ECO:0000255	15..57		29/41 (71%)
		CTD_bind	212..271	CDD:282648	31/59 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..549		51/240 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..635		7/37 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	722..878		77/199 (39%)
		G_patch	839..889	CDD:197727	33/50 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160166
Domainoid	1	1.000	180	1.000	Domainoid score	I3519
eggNOG	1	0.900	-	-		E1_KOG4368
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1486
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48532
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	1	1.000	-	-		FOG0006072
OrthoInspector	1	1.000	-	-		oto91192
orthoMCL	1	0.900	-	-		OOG6_108174
Panther	1	1.100	-	-	LDO	PTHR12323
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3181
SonicParanoid	1	1.000	-	-		X4367
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890