DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scaf6 and SF3A1

DIOPT Version :9

Sequence 1:	NP_001014589.1	Gene:	scaf6 / 3346235	FlyBaseID:	FBgn0261872	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_005868.1	Gene:	SF3A1 / 10291	HGNCID:	10765	Length:	793	Species:	Homo sapiens

Alignment Length:	874	Identity:	175/874 - (20%)
Similarity:	281/874 - (32%)	Gaps:	305/874 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VQPPRDASLRNIIDKLAEFVARNGPEFEAITKQKQQNNPKFEFLYGGE-FANYYQFRVAAEQALL 66
            :.||.:  :|||:||.|.|||||||||||..:|.:.|||||.||...: :..||:.:|:..:...
Human    43 IYPPPE--VRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKEGK 105

  Fly    67 KQQAINQQLPPGAPSGHYMQHPPPMQQSQPPGLYPPPNQQPPHPPETAQDNMQQQT-----QHSW 126
            .|:          ||...   |..|||.|                :|.|..:.|:.     |.:.
Human   106 AQE----------PSAAI---PKVMQQQQ----------------QTTQQQLPQKVQAQVIQETI 141

  Fly   127 PPNSGNGGPPNNQQANGNPMAMNLTSQLEAIKMQQKSLREQIQQSEANLSAQHTALMNQKTKQIE 191
            .|..    ||...:...:|.::: ...|:.:|                |:||..|   :..:|.
Human   142 VPKE----PPPEFEFIADPPSIS-AFDLDVVK----------------LTAQFVA---RNGRQF- 181

  Fly   192 DAIAAAQTAQQEQMAGEQGIVLRDFDGVLQPIIESCTKDSISAGKNWILQHSTDSAKINVVLQYL 256
                ..|..|:||...:       || .|:|                  |||..:....:|.||
Human   182 ----LTQLMQKEQRNYQ-------FD-FLRP------------------QHSLFNYFTKLVEQY- 215

  Fly   257 LKKALVNGSTFQQKLHLIYLVNDILHHCMRKNINDLKNSLENVVIPMFCSADLIGNPDQRQKLAK 321
             .|.|:.......||              :|...:.:..|:.|...:
Human   216 -TKILIPPKGLFSKL--------------KKEAENPREVLDQVCYRV------------------ 247

  Fly   322 LLSLWESKAKFFDACVISKLQSPDSSMQEYKTNLQNTHHDI----TAKFTQNTKATLDNYQKQHH 382
               .|   |||.:.   .:.:..:...:|.....|...||.    |..|..|.:...........
Human   248 ---EW---AKFQER---ERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEE 303

  Fly   383 VFIQHASQQIVQLEKQAQHLEQQIVAQKSQQQHMLQHQQKNIPSLMSHRIAMPGDHEHMNSQGPH 447
            :..:...|:..:...:::.:|.::   :|.::...|.:.:..||.:.....:    :.|: :|..
Human   304 LGARILIQERYEKFGESEEVEMEV---ESDEEDDKQEKAEEPPSQLDQDTQV----QDMD-EGSD 360

  Fly   448 DQQHPQAGNNMYPGGNFQQQQPPPGNHFADPRGP--------NFFIPDMSKPPPGFPGPMHHNQG 504
            |::..            |:..|||......|..|        ..:.|..|||.|..|.|..:...
Human   361 DEEEG------------QKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVS 413

  Fly   505 PAMGQQQP--------QPGQFPP------------------MQAPGSGNEPPVD---------LG 534
            |..|::.|        :.|...|                  :.|||...|..:.         .|
Human   414 PITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFG 478

  Fly   535 VLSAAIQACLQMQQQHHPDD-------------PQQQGQHQLQQQQQ------------------ 568
            |...||...:..::...|::             .||..|..:..|:|
Human   479 VEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKE 543

  Fly   569 ----QQPQQ--QKQPPPMAAYPQNIVRPGQQNADSSEVDLDVLNAAIRAVITNKPEDGTLEDGQQ 627
                .:|.:  |:.|||.:|          .|..||           ...||:.|...|:    .
Human   544 KIGPSKPNEIPQQPPPPSSA----------TNIPSS-----------APPITSVPRPPTM----P 583

  Fly   628 PQKLVDGESGEPVVIGEPQIPTAPYYDLPAGLMV----PLIRLEDYNYKALDPA--DIRLPAPAP 686
            |.......|..||:   |:.|.|....||.|.::    |:|.....|...:.|:  .|..|.|.|
Human   584 PPVRTTVVSAVPVM---PRPPMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPP 645

  Fly   687 QSERLTNALNAFYSAPS-------------H-DRPRDNEGWEKLGLYEYYKVKNAARKQKEEEIK 737
            ..     ...||..||.             | ..|.::|...|       |:|.......|||.
Human   646 MI-----VPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSK-------KLKTEDSLMPEEEF- 697

  Fly   738 DGIREKSRSPSPIVLEKPLPKKSNKRVYR 766
              :|   |:..|:.::..:|...:|..::
Human   698 --LR---RNKGPVSIKVQVPNMQDKTEWK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scaf6	NP_001014589.1	Surp	13..61	CDD:280053	27/48 (56%)
		CTD_bind	271..329	CDD:282648	5/57 (9%)
		G-patch	885..933	CDD:279867
SF3A1	NP_005868.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		175/874 (20%)
		SWAP	50..103	CDD:197818	28/52 (54%)
		SURP motif 1	52..94		23/41 (56%)
		Surp	165..215	CDD:396395	18/99 (18%)
		SURP motif 2	166..208		17/91 (19%)
		PRP21_like_P	232..472	CDD:403444	44/286 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..428		24/129 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..518		3/29 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..584		13/78 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..688		6/29 (21%)
		Required and sufficient for nuclear import. /evidence=ECO:0000269\|PubMed:21349847	680..702		8/34 (24%)
		Ubl_SF3a120	704..786	CDD:340498	3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0007
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910