DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr2 and lrig2

DIOPT Version :9

Sequence 1:	NP_001014480.4	Gene:	dpr2 / 3346227	FlyBaseID:	FBgn0261871	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	XP_021332954.1	Gene:	lrig2 / 571101	ZFINID:	ZDB-GENE-041111-75	Length:	1044	Species:	Danio rerio

Alignment Length:	312	Identity:	66/312 - (21%)
Similarity:	110/312 - (35%)	Gaps:	81/312 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 PRNITTRTGHTAAINCRVDNLGDKSVSW----------IRKRDLHILTAGILTYTSDERFKVVRT 167
            |.::|.|||..|.:.|..:......::|          .|:|.:|::
Zfish   563 PMDLTIRTGTVARLECAAEGHPTPQIAWQKDGGINFPAARERRMHVM------------------ 609

  Fly   168 ADSKDWTLHVKYAQPRDSGIYECQVNTEP-KISMAFRLNVIVTPPDAKAIIAGPTDLYVKVGSSV 231
              ..|.|..:...:..|.|:|.|....|. .:|....|.|:.||...:.:    .|..|..|.:.
Zfish   610 --PDDDTFFIANVKAEDMGVYSCTAKNEAGSLSANATLTVLETPSFQRPL----EDRNVARGETA 668

  Fly   232 TLTCHVK-QPATSAQDIGPIYWYR--GPYILTP--FVAHPNDAAIDLQRISMESTLAEKLQSRLR 291
            .|.|..: .||..      :.|.:  .|.:||.  |.|..|...|
Zfish   669 VLQCIARGSPAPR------LNWTKDDAPLVLTERHFFAAANQLLI-------------------- 707

  Fly   292 IANAQLLDTGNYTCMPTT---AEAASVVVNV---INDESPAAMQKSRAIRTSGSMRSSRLVLLLA 350
            |.:|...|.|.|||:.:.   .|...:.::|   .|.:..:::.......|.|.:   .:|::..
Zfish   708 IVDAGPADAGKYTCIMSNTLGTERGHIYLSVSPSANCDPGSSVYGHDGWTTVGIV---VMVVVCC 769

  Fly   351 MVASSVVRWLIGGQRIGSNSCHDSCSNLSTLHINYCNLRAKITSHLKEHRCL 402
            :|.:|:| |:|....:...|...|.:|...:     ||.|.|.|:|.....|
Zfish   770 VVGTSLV-WVIVIYHMRRKSEDYSITNTDEM-----NLPADIPSYLSSQGTL 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr2	NP_001014480.4	IG_like	113..206	CDD:214653	20/103 (19%)
		Ig	116..192	CDD:299845	16/85 (19%)
		ig	220..306	CDD:278476	21/90 (23%)
		IG_like	220..306	CDD:214653	21/90 (23%)
lrig2	XP_021332954.1	NEL	<7..>191	CDD:330839
		leucine-rich repeat	38..57	CDD:275380
		leucine-rich repeat	58..81	CDD:275380
		leucine-rich repeat	83..104	CDD:275380
		PLN00113	<128..>403	CDD:331614
		leucine-rich repeat	128..151	CDD:275380
		leucine-rich repeat	152..174	CDD:275380
		leucine-rich repeat	175..198	CDD:275380
		leucine-rich repeat	199..246	CDD:275380
		leucine-rich repeat	247..270	CDD:275380
		LRR_8	270..329	CDD:316378
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..318	CDD:275380
		leucine-rich repeat	319..345	CDD:275380
		leucine-rich repeat	346..369	CDD:275380
		leucine-rich repeat	370..391	CDD:275380
		LRRCT	403..451	CDD:214507
		Ig	459..553	CDD:325142
		Ig_1	574..648	CDD:143240	15/93 (16%)
		I-set	651..738	CDD:254352	24/116 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910