DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr2 and dscama

DIOPT Version :9

Sequence 1:	NP_001014480.4	Gene:	dpr2 / 3346227	FlyBaseID:	FBgn0261871	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	XP_021334866.1	Gene:	dscama / 568643	ZFINID:	ZDB-GENE-050310-7	Length:	2025	Species:	Danio rerio

Alignment Length:	384	Identity:	78/384 - (20%)
Similarity:	144/384 - (37%)	Gaps:	72/384 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 AVKSLSHLVDGNDNLLPMVSAPSSI--DNDYVYIASVNRKFPQFG-------NSIDDEREAEEQ- 96
            :|::...:|....:.:|:||....:  ....:||..|.::...|.       ....:.|::...
Zfish   150 SVENYITVVSWERDTVPLVSGARFLITSTGALYILDVQKEDELFNYRCMTRHRYTSETRQSNSAR 214

  Fly    97 ---PPEETTYPPPVFDFGMPRNITTRTGHTAAINCRVDNLGDKSVSWIR-KRDLHILTAGILTYT 157
               |.:.:...|.:.|....|.:  ...|...:.|:..........|:: .|.|.
Zfish   215 LFVPADPSNSAPAILDGFEKREV--MASHRVELPCKASGHPAPKYRWLKNNRPLE---------- 267

  Fly   158 SDERFKVVRTADSKDWTLHVKYAQPRDSGIYECQV-NTEPKISMAFRLNVIVTPPDAKAIIAGPT 221
            ||.||:...|.      |.::.|||.|:|.|.|:| |:.....:..||.|   ....||::: |.
Zfish   268 SDSRFRQSVTG------LLIERAQPSDTGSYVCEVWNSYGNAEVIGRLTV---KEPLKAVVS-PR 322

  Fly   222 DLYVKVGSSVTLTCHVKQPATSAQDIGPIYWYR-GPYILTPFVAHPNDAAIDLQRISMESTLAEK 285
            .:...|||.|:|:|.|     :..|...:.||| |..|.|       .|.|.:..|:.|:.:.:.
Zfish   323 KVKGSVGSQVSLSCSV-----TGSDEFELSWYRNGDKINT-------GANIRMNGINKENLVMDG 375

  Fly   286 LQSRLRIANAQLLDTGNYTCMPTTAE-AASVVVNVINDESPAAMQKSRAIRTSGSMRSSRLVLLL 349
            :...         |.|.|.|....|: :|...|.||.::....:..:.:.:..|......|...:
Zfish   376 MAKS---------DGGVYQCFSRKAKMSAQDFVQVILEDGTPKILSAFSEKVVGPNDFVSLTCHV 431

  Fly   350 AMVASSVVRWLIGGQRIGSNSCHDSCSNLSTLH--INYCNLRAKITSHLK-----EHRC 401
            .......:.|.:..:.:..:|.|....:::...  ::|.|:     ||::     .:||
Zfish   432 KGTPQPAITWTLDDEVVAKDSRHRIVHSITAEGNVVSYLNI-----SHIQVRDSGVYRC 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr2	NP_001014480.4	IG_like	113..206	CDD:214653	23/94 (24%)
		Ig	116..192	CDD:299845	18/76 (24%)
		ig	220..306	CDD:278476	22/86 (26%)
		IG_like	220..306	CDD:214653	22/86 (26%)
dscama	XP_021334866.1	Ig	124..217	CDD:325142	10/66 (15%)
		I-set	236..311	CDD:254352	22/92 (24%)
		IG_like	321..402	CDD:214653	26/101 (26%)
		I-set	408..502	CDD:333254	11/83 (13%)
		IGc2	524..579	CDD:197706
		Ig	614..679	CDD:319273
		Ig_DSCAM	708..787	CDD:143211
		Ig	805..898	CDD:325142
		FN3	894..988	CDD:238020
		FN3	995..1092	CDD:238020
		fn3	1100..1186	CDD:306538
		fn3	1199..1282	CDD:306538
		Ig	1312..1377	CDD:319273
		fn3	1405..1471	CDD:306538
		FN3	1492..1563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910