DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr2 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001014480.4	Gene:	dpr2 / 3346227	FlyBaseID:	FBgn0261871	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	285	Identity:	67/285 - (23%)
Similarity:	107/285 - (37%)	Gaps:	64/285 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 PRNITTRTGHTAAINCRVDNLGDKSVSWIRKRDLHILTAGILTYTSD-------------ERFKV 164
            |.:.|...|..|.:.|.:.|.                 :||:.:|.|             .|::|
Human    27 PADQTVVAGQRAVLPCVLLNY-----------------SGIVQWTKDGLALGMGQGLKAWPRYRV 74

  Fly   165 VRTADSKDWTLHVKYAQPRDSGIYECQVNTEPKISMAFRLNVIVTPPDAKAIIAGPTDLYVKVGS 229
            |.:||:..:.|.:..|:..|...||||.......|...:|.|::.|.|.: |..||. :.::.|:
Human    75 VGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTR-IDGGPV-ILLQAGT 137

  Fly   230 SVTLTCHVKQPATSAQDIGPIYWYRGPYILTPFVAHPNDAAIDLQRISMESTLAEKLQSRLRIAN 294
            ...|||.    |.:|:....|.|:|........|     |:.:|.:.....|...:|     :.|
Human   138 PHNLTCR----AFNAKPAATIIWFRDGTQQEGAV-----ASTELLKDGKRETTVSQL-----LIN 188

  Fly   295 AQLLDTGN-YTC------MPTTAEAASVVVNVINDESPAAMQKSRAIRTSGSMRSSRLVLLLAMV 352
            ...||.|. :||      :|:..| .|:.::|   ..|..:..|  |.........|:|......
Human   189 PTDLDIGRVFTCRSMNEAIPSGKE-TSIELDV---HHPPTVTLS--IEPQTVQEGERVVFTCQAT 247

  Fly   353 ASSVV---RWLIGGQRIGSNSCHDS 374
            |:..:   ||..||..|  ...|:|
Human   248 ANPEILGYRWAKGGFLI--EDAHES 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr2	NP_001014480.4	IG_like	113..206	CDD:214653	24/105 (23%)
		Ig	116..192	CDD:299845	20/88 (23%)
		ig	220..306	CDD:278476	21/92 (23%)
		IG_like	220..306	CDD:214653	21/92 (23%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	24/105 (23%)
		Ig	25..116	CDD:299845	24/105 (23%)
		Ig2_KIRREL3-like	138..219	CDD:143236	22/95 (23%)
		I-set	223..304	CDD:254352	12/52 (23%)
		Ig_2	227..305	CDD:290606	12/48 (25%)
		Ig_2	311..405	CDD:290606
		IG_like	314..405	CDD:214653
		Ig5_KIRREL3	407..504	CDD:143306
		IG_like	416..504	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910