DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr2 and Dscam2

DIOPT Version :9

Sequence 1:	NP_001014480.4	Gene:	dpr2 / 3346227	FlyBaseID:	FBgn0261871	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	79/378 - (20%)
Similarity:	131/378 - (34%)	Gaps:	128/378 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ATPILVIMISISRAWTMQQQHLSPAIQQHPAVKSLSHLVDGNDNLLPMVS-------APS----- 64
            |.|:|:        ::..:|.|.|.    ||| ||.....||..  |.:|       .||
  Fly   421 APPVLL--------YSFIEQTLQPG----PAV-SLKCSAAGNPT--PQISWTLDGFPLPSNGRFM 470

  Fly    65 -----SIDNDYVYIASVNRKFPQFGNS---IDDEREAEEQPPEETTYPPPVFDFGMP-----RNI 116
                 ::..|.:...:::....:.|..   |.:.|....|.......      :|:|     ..:
  Fly   471 IGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNI------YGLPYIRLIPKV 529

  Fly   117 TTRTGHTAAINCRVDNLGDKSVSWIR-KRDLHILTAGILTYTSDERFKVVRTADSKDWTLHVKYA 180
            |..:|.|..:.|.|.....:.:.|.| .|:|           .|:    :|.....|.:|.:...
  Fly   530 TAVSGETLNLKCPVAGYPIEEIHWERGGREL-----------PDD----IRQRVQPDGSLTISPV 579

  Fly   181 QPR-DSGIYEC----------------QVNTEPKISMAFRLNVIVTPPDAKAIIAGPTDLYVKVG 228
            |.. |||:|.|                .|...||:| .|:.|:                |.:.:|
  Fly   580 QKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLS-PFQTNI----------------LQLNMG 627

  Fly   229 SSVTLTCHVKQ---PATSAQDIGPIYWYRGPYILTPFVAHPNDAAIDLQRISMESTLAEKLQSRL 290
            ...:|||.|.:   |.|       |.|.:....:.|           .|.:|::.  .::..|.|
  Fly   628 DRASLTCSVVKGDLPLT-------INWRKDGRPIDP-----------TQHMSVKQ--VDQYNSIL 672

  Fly   291 RIANAQLLDTGNYTCMPTTAEA-----ASVVVNV----INDESPAAMQKSRAI 334
            .|.|.....||||:|:...:.|     .:::|||    |.:...|.::::|.|
  Fly   673 VIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVERNRHI 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr2	NP_001014480.4	IG_like	113..206	CDD:214653	25/115 (22%)
		Ig	116..192	CDD:299845	19/93 (20%)
		ig	220..306	CDD:278476	21/88 (24%)
		IG_like	220..306	CDD:214653	21/88 (24%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	19/91 (21%)
		IGc2	436..507	CDD:197706	16/77 (21%)
		I-set	521..610	CDD:254352	21/103 (20%)
		IGc2	533..597	CDD:197706	18/78 (23%)
		Ig	630..699	CDD:143165	21/88 (24%)
		IG_like	714..802	CDD:214653	3/12 (25%)
		Ig	725..802	CDD:299845	1/1 (100%)
		Ig	823..894	CDD:143165
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910