DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr2 and SDK1

DIOPT Version :9

Sequence 1:NP_001014480.4 Gene:dpr2 / 3346227 FlyBaseID:FBgn0261871 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:351 Identity:79/351 - (22%)
Similarity:127/351 - (36%) Gaps:91/351 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 VSAPSSID-NDYVYIASVNRKFPQFGNSIDDEREAEEQPPEETTY----PPPVFDFGMPRNITTR 119
            :|.|:|.| ..||..|::.      |::.        :|...|.:    .||.|.......|:..
Human   349 ISNPTSADTGPYVCEAALP------GSAF--------EPARATAFLFIIEPPYFTAEPESRISAE 399

  Fly   120 TGHTAAINCRVDNLGDKSVSWIRKRDLHILTAGILTYTSDERFKVVRTADSKDWTLHVKYAQPRD 184
            ...|..|.|:...:...::.|.:       .|..::...:.|:||:.:..     |.::..:|.|
Human   400 VEETVDIGCQAMGVPLPTLQWYK-------DAISISRLQNPRYKVLASGG-----LRIQKLRPED 452

  Fly   185 SGIYECQVNTE-PKISMAFRLNVIVTPPDAKAIIAGPTDLYVKVGSSVTLTCHVK---QPATSAQ 245
            |||::|..:.| .:|.....|:|....|   .....|.|..|..|.:..|.|.|.   :||    
Human   453 SGIFQCFASNEGGEIQTHTYLDVTNIAP---VFTQRPVDTTVTDGMTAILRCEVSGAPKPA---- 510

  Fly   246 DIGPIYWYRGPYILTPFVAHPNDAAIDLQRISMESTLAEKLQS-RLRIANAQLLDTGNYTCMPTT 309
                |.|.|..:||.       ..::.:.|..:       |:| .|:||...:.|.|||||....
Human   511 ----ITWKRENHILA-------SGSVRIPRFML-------LESGGLQIAPVFIQDAGNYTCYAAN 557

  Fly   310 AEA---ASVVVNVIN-------DESPAAMQKSRAIRTSGSMRSSRLVLL-------LAMVASSVV 357
            .|.   ||..:.|.|       .|....::.:.|....|:....|:.|.       :|:..||..
Human   558 TEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTS 622

  Fly   358 RWLI------------GGQRIGSNSC 371
            |.::            .|. ||..||
Human   623 RIVVEKDGSLLISQTWSGD-IGDYSC 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr2NP_001014480.4 IG_like 113..206 CDD:214653 19/93 (20%)
Ig 116..192 CDD:299845 16/75 (21%)
ig 220..306 CDD:278476 25/89 (28%)
IG_like 220..306 CDD:214653 25/89 (28%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706 6/14 (43%)
I-set 386..475 CDD:254352 21/100 (21%)
Ig 404..472 CDD:143165 16/79 (20%)
I-set 480..570 CDD:254352 30/114 (26%)
Ig 494..570 CDD:299845 26/97 (27%)
I-set 575..664 CDD:254352 14/74 (19%)
Ig 580..664 CDD:299845 14/69 (20%)
FN3 668..759 CDD:238020
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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