Protein Alignment ppk13 and ASIC3

DIOPT Version :10

• Sequence 1: NP_001014495.1
• Gene: ppk13 / 3346226
• FlyBaseID: FBgn0053508
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 96/510 - (18%)
• Similarity: 167/510 - (32%)
• Gaps: 147/510 - (28%)

  Fly     7 IEEYLKNSTLHGARFIVDKDASWIERIFWVICLVASWYASWLLIKASLSAFENNAISFVVESSFR 71
            |..:..|.::||...:....:..:.|..|...:|.| .|::|...|....:..   .|..:::..
Human    17 IRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLS-VATFLYQVAERVRYYR---EFHHQTALD 77

  Fly    72 DWNTN---FPAIIVCESKNMDRIQEVAEQL-WGADHDFTLEEVLSEIAFFRGESYHTVHECSGEE 132
            :..::   |||:.:|....:.|.:.....| |.......|:.. ...||.|         ..|..
Human    78 ERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA-EHAAFLR---------ALGRP 132

  Fly   133 VTASCFYSNFSY-----YAELVRSSCVDSISNCEWNNKPFECC--KYFHRMETELGICYAINSMQ 190
            .....|..:.::     ||. ...|..|.:.:|.:..:|   |  :.|..:.|.:|.||..||..
Human   133 PAPPGFMPSPTFDMAQLYAR-AGHSLDDMLLDCRFRGQP---CGPENFTTIFTRMGKCYTFNSGA 193

  Fly   191 AGKPKMPKLNMYSNRGSGPGA-----------LKMELHTEATVFILG------TEEVPTLVTPKT 238
            .|    .:|...:..|.|.|.           |.:....|.|.|.:|      ::|.|.::
Human   194 DG----AELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPII---- 250

  Fly   239 DFLVVGPYISFVRYISKRDIENDEEIRQTSVHQRNCRFADENILDVHKF---------------- 287
            |.|.:|....:..::|.:    .:::........:|..|..|    ..:
Human   251 DQLGLGVSPGYQTFVSCQ----QQQLSFLPPPWGDCSSASLN----PNYEPEPSDPLGSPSPSPS 307

  Fly   288 --YSYSACTVQCRKDRQMELCNCSSHLSPNSPDWQLCNMEGLECLNRNYEDLSVIIAKWSKLRGR 350
              |:...|.:.|........|.|.....|.  |..:|:.:  :..|..:..:..::.|.|
Human   308 PPYTLMGCRLACETRYVARKCGCRMVYMPG--DVPVCSPQ--QYKNCAHPAIDAMLRKDS----- 363

  Fly   351 KGLVCDCLPSCTEVDITTVYDSKENMAGSQNAISRIEVGLIELPTERYKRNLVRGKL-------- 407
                |.|...|.    :|.|..              |:.::.:|:....|.|.| ||
Human   364 ----CACPNPCA----STRYAK--------------ELSMVRIPSRAAARFLAR-KLNRSEAYIA 405

  Fly   408 ---------------------------DLVVSIGGTTGLFVGASLLSFVEIFYYI 435
                                       :|:..|||..|||:|||||:.:||..|:
Human   406 ENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:459966	94/504 (19%)
ASIC3	NP_064717.1	ENaC	20..534	CDD:273304	95/507 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		2/25 (8%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	447..449		1/1 (100%)