Protein Alignment ppk13 and SCNN1D

DIOPT Version :9

• Sequence 1: NP_001014495.1
• Gene: ppk13 / 3346226
• FlyBaseID: FBgn0053508
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 108/567 - (19%)
• Similarity: 186/567 - (32%)
• Gaps: 172/567 - (30%)

  Fly     3 FSRVIEEYLKNSTLHGARFIVDKDASWIERIFWVI----CLVASWYASWLLIKASLSAFENN--- 60
            |..::..:..|:|:|||..:|....:.::...|.:    .|||..:...||       ||.:
Human   220 FRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLL-------FERHWHR 277

  Fly    61 ----AISFVVESSFRDWNTNFPAIIVCESKNMDRIQEVAEQLWGADHDFTLEEV--LSEIAFFRG 119
                |:|...|...      .|.:.:|:. |..|...|...|...| :|..|.:  |..:...:|
Human   278 PVLMAVSVHSERKL------LPLVTLCDG-NPRRPSPVLRHLELLD-EFARENIDSLYNVNLSKG 334

  Fly   120 ES------------YHTVHEC-------SGEEVT----------ASCFYSNFS------------ 143
            .:            :|...|.       ||..|.          ..|||..::
Human   335 RAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHF 399

  Fly   144 YYAE---LVRSSCVDS--------ISNCEWNNKPFECCKY--FHRMETELGICYAINSMQAGKPK 195
            :|.:   |:.::..||        :.:|.::....:..::  ||  ....|.||.::.:...:
Human   400 HYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFH--HPTYGSCYTVDGVWTAQ-- 460

  Fly   196 MPKLNMYSNRGSGPGALKMELHTEATVFILGTEEVPTLVTPKT----DFLVVG----PYISFVRY 252
                        .||.      |.....:|..|:.|.|....|    ..:|.|    |::....:
Human   461 ------------RPGI------THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSF 507

  Fly   253 ISKRDIENDEEIRQTSVHQ-----RNCRFADENI---LDVHKFYSYSACTVQCRKDRQMELCNCS 309
            ..:...|....||:..||:     .:|....|.:   |..:..|:..||.|.|.:...:|.|:|.
Human   508 SVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCG 572

  Fly   310 SHLSP-----------NSPDWQLCNMEGLECLNRNYEDLSVIIAKWSKLRGRKGLVC------DC 357
            .:|.|           ..|.|.       .|..|.|:||..           ..|.|      .|
Human   573 YYLHPLPAGAEYCSSARHPAWG-------HCFYRLYQDLET-----------HRLPCTSRCPRPC 619

  Fly   358 LPSCTEVDITTVYDSKENMAG-----------------SQNAISRIEVGLIELPTERYKRNLVRG 405
            ..|..::...|........||                 .::::::|.:...||.....:...|..
Human   620 RESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYS 684

  Fly   406 KLDLVVSIGGTTGLFVGASLLSFVEIFYYITIRPYTTYINEKRRLKR 452
            ...|:.::|....|:.|||:||.:|:...:......|.:...|||:|
Human   685 VPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRR 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:279230	102/540 (19%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211
		ENaC	219..784	CDD:273304	108/567 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820