Protein Alignment ppk13 and ASIC5

DIOPT Version :9

• Sequence 1: NP_001014495.1
• Gene: ppk13 / 3346226
• FlyBaseID: FBgn0053508
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 123/536 - (22%)
• Similarity: 213/536 - (39%)
• Gaps: 165/536 - (30%)

  Fly     9 EYLKNSTLHGARFIVDKDASWIERIFWVICLVAS-----W--------YASWLLIKASLSAFENN 60
            ::..:::.||...|| ::.|.|.|:.|::.::.|     |        |.:|    .:.::.|
Human    40 DFAISTSFHGIHNIV-QNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTW----PTTTSIE-- 97

  Fly    61 AISFVVESSFRDWNTNFPAIIVCESKNMDRIQEVAEQLWGADHDFTLEEVLSEIAFFRGESYHTV 125
             :.:|.:       ..|||:..|   |::|.|..|...:|.  .|.|..::|::...:..:.::.
Human    98 -VQYVEK-------MEFPAVTFC---NLNRFQTDAVAKFGV--IFFLWHIVSKVLHLQEITANST 149

  Fly   126 HECSGEEVTASCFYSNFSYYAELVRSSCV----DSISNCEWNNKPFECC-KYFHRMETELGICYA 185
            ......:..||  :.||| ..|.:|:...    .::.:||:..||  |. |.|..:.||.|.|:.
Human   150 GSREATDFAAS--HQNFS-IVEFIRNKGFYLNNSTLLDCEFFGKP--CSPKDFAHVFTEYGNCFT 209

  Fly   186 IN---SMQAGKPKMPKLNMYSNRGSGPG-ALKMELHTEATVFILGTEEVPTLVTPKTDFLVVGPY 246
            .|   ::||.:    |:::     ||.| :|...::.||.     |:      .|...|:..|
Human   210 FNHGETLQAKR----KVSV-----SGRGLSLLFNVNQEAF-----TD------NPALGFVDAG-- 252

  Fly   247 ISFVRYISKRDIEND-------------EEIRQT-SVHQR----NCRFADENI-LDVHKFYSYSA 292
            |.||.:..|:..:.|             ..|||. :|||.    .|   :.|| |.....||.|.
Human   253 IIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGEC---NPNIKLQNFSSYSTSG 314

  Fly   293 CTVQCRKDRQMELCNCSSHLSPNSPDWQLCNMEGLEC-LNRNYEDLSVII--AKWSKLRGRKGLV 354
            |..:|:.....:.|.|...|.|.         .|:|| |.:.:..:|.::  .::..|
Human   315 CLKECKAQHIKKQCGCVPFLLPG---------YGIECDLQKYFSCVSPVLDHIEFKDL------- 363

  Fly   355 C-------DCLPSCTEVD--ITTVYDSKENMAGSQNAISRIEVGLIELPTERY-KRNLVRGKL-- 407
            |       .|..||.|::  .|..|.|    ..||.|:..:...|.:  :.:| :.|||:.::
Human   364 CTVGTHNSSCPVSCEEIEYPATISYSS----FPSQKALKYLSKKLNQ--SRKYIRENLVKIEINY 422

  Fly   408 -----------------DLVVSIGGTTGLFVGASLLSFVEI-------FYYITI----------- 437
                             :|:..:||..|||.||||::.:||       ||:|.|
Human   423 SDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQ 487

  Fly   438 --RPYTTYINEKRRLK 451
              .|...::..|.|::
Human   488 WTPPPQNHLGNKNRIE 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:279230	117/503 (23%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	116/496 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820