Protein Alignment ppk13 and ASIC1

DIOPT Version :10

• Sequence 1: NP_001014495.1
• Gene: ppk13 / 3346226
• FlyBaseID: FBgn0053508
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 104/536 - (19%)
• Similarity: 187/536 - (34%)
• Gaps: 159/536 - (29%)

  Fly     7 IEEYLKNSTLHGARFIVDKDASWIERIFWVICLVASWYASWLLIKASLSAFEN----NAISFVVE 67
            |:.:..:|||||...|...:...::|..|.:|.:.|......:....:..:.:    ..:..|..
Human    18 IQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAA 82

  Fly    68 SSFRDWNTNFPAIIVCESKNMDRIQEVAE-QLWGADH-----------------DFTLEEVLSEI 114
            |..     .|||:.:| :.|..|..:|:: .|:.|..                 |....|:|.:.
Human    83 SQL-----TFPAVTLC-NLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDK 141

  Fly   115 AFFRG-----ESYHTVHECSGEEVTASCFYSNFSYYAELVRSSCVDSISNCEWNNKPFECC--KY 172
            |.||.     .:....::.:|.::.                    |.:.:|.:..   |.|  :.
Human   142 ANFRSFKPKPFNMREFYDRAGHDIR--------------------DMLLSCHFRG---EVCSAED 183

  Fly   173 FHRMETELGICYAINSMQAGKPKMPKLNMYSNRGSGPGALKMEL------------HTEATVFIL 225
            |..:.|..|.||..||.:.|:|::..:    ..|:|.| |::.|            .|:.|.|..
Human   184 FKVVFTRYGKCYTFNSGRDGRPRLKTM----KGGTGNG-LEIMLDIQQDEYLPVWGETDETSFEA 243

  Fly   226 G------TEEVPTLVTPKTDFLVVGPYISFVRYISKRDIENDEEIRQTSVHQR---------NCR 275
            |      :::.|    |..|.|..|....|..:::.::             ||         .|:
Human   244 GIKVQIHSQDEP----PFIDQLGFGVAPGFQTFVACQE-------------QRLIYLPPPWGTCK 291

  Fly   276 FAD-ENILDVHKFYSYSACTVQCRKDRQMELCNCSS-HLSPNSP-----DWQLCNMEGLECLNRN 333
            ... ::.||....||.:||.:.|.....:|.|||.. |:..::|     .::.|....|:.|...
Human   292 AVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEK 356

  Fly   334 YEDLSVIIAKWSKLRGRKGLVCDCLPSCTEVD-ITTVYDSKENMAGSQNAISRIEVGLIELPT-E 396
            .::..|.....:..|..|.|....:||..... :...::..|...|....:..|...::...| |
Human   357 DQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIE 421

  Fly   397 RYKRNLVRGKL-DLVVS------------------------------------------IGGTTG 418
            :.|...:.|.| :|:::                                          |||..|
Human   422 QKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMG 486

  Fly   419 LFVGASLLSFVEIFYY 434
            ||:|||:|:.:|:|.|
Human   487 LFIGASILTVLELFDY 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:459966	102/531 (19%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	103/535 (19%)