DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk13 and asic2

DIOPT Version :9

Sequence 1:	NP_001014495.1	Gene:	ppk13 / 3346226	FlyBaseID:	FBgn0053508	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	XP_005164179.1	Gene:	asic2 / 407669	ZFINID:	ZDB-GENE-040513-4	Length:	564	Species:	Danio rerio

Alignment Length:	534	Identity:	114/534 - (21%)
Similarity:	182/534 - (34%)	Gaps:	159/534 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRVIEEYLKNSTLHGARFIVDKDASWIERIFWVIC------LVASWYASWLLIKASLSAFENNAI 62
            ||:....|..:.|||.|.|.....|...|.||:|.      |:.||.::.||          :.:
Zfish    61 SRLTVALLSRTRLHGLRHICSPSNSLSRRAFWMIAFCTCLGLLLSWSSNRLL----------HWL 115

  Fly    63 SFVVESSFR-DW--NTNFPAIIVCESKNMDRIQEVAEQLWGADH-------DFTLEEVLSEIA-- 115
            :|...:... :|  ...||.:.:|.:..:.........|:.|.|       :.|...::.::.
Zfish   116 AFPTHTRVHTEWAKELAFPTVTICNNNPVRLYHLTKSDLYFAGHWLGLLLANRTARPLVLDLLQD 180

  Fly   116 -----FFRGESYHTVHECSGEEVTASCFYSNFSYYAELVRSSCVDSISNCEWNNKPFECCKY-FH 174
                 |.:...:.........|.|:..|.....:..|       |.:..|::..:|  |..: |.
Zfish   181 DRRGWFSKLSDFRLFLPPRRFEGTSLEFMDRLGHQLE-------DMLLACKYRGEP--CGAHNFS 236

  Fly   175 RMETELGICYAINSMQAGKPKMPKLNMYSNRGSGPGALKMEL------------HTEATVFILGT 227
            .:.|..|.||..|:.:.||    .|......|:|.| |::.|            .||.|.|..|.
Zfish   237 TVFTRYGKCYMFNAAEEGK----TLRTTMKGGTGNG-LEIMLDIQQDEYLPVWGETEETAFEAGV 296

  Fly   228 E-EVPTLVTP----KTDFLVVGPYISFVRYISKRDIENDEEIRQTSVHQ--RNC--RFADENILD 283
            . ::.:...|    :..|.|...:.:||.         .:|.|.|.:..  ..|  |..|..:..
Zfish   297 RVQIHSQAEPPFVHELGFGVAPGFQTFVA---------TQEQRLTYLPPPWGECVSRALDSGLFQ 352

  Fly   284 VHKFYSYSACTVQCRKDRQMELCNCSSHLSPNSPDWQLCNMEGLECLNRNYEDLS-VIIAKWSKL 347
            |   ||.|||.::|.....:|.|||.....|....:         |....|:|.: ..:|..|.:
Zfish   353 V---YSVSACRIECETRYIVENCNCRMVYMPGDSPY---------CTPEQYKDCAEPALAALSAV 405

  Fly   348 RGRKGLVCDCLPSCTEVDITTVYDSKENMAGSQNAISRIEVGLIELPTERYKRNL---------- 402
            .|..   |.|...|.    .|.|:.              |:.::::|::...|.|
Zfish   406 EGTN---CICRSPCN----MTRYNK--------------ELSMVKIPSKTSARYLEKKFNRSEKY 449

  Fly   403 ---------------------------VRGKLDLVVSIGGTTGLFVGASLLSFVEIFYYITIRPY 440
                                       |.|   |:..|||..|||:|||:|:.:|:|.|
Zfish   450 ITDNILVLDVFFEALNYETIEQKKAYEVAG---LLGDIGGQMGLFIGASILTLLELFDY------ 505

  Fly   441 TTYINEKRRLKRLI 454
             .|...|.||..|:
Zfish   506 -AYEVVKERLLDLL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:279230	106/506 (21%)
asic2	XP_005164179.1	ASC	71..538	CDD:295594	111/524 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020