DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk13 and asic4a

DIOPT Version :9

Sequence 1:	NP_001014495.1	Gene:	ppk13 / 3346226	FlyBaseID:	FBgn0053508	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	510	Identity:	107/510 - (20%)
Similarity:	182/510 - (35%)	Gaps:	147/510 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 STLHGARFIVDKDASWIERIFWVICLVASWYASWL--LIKASLSAFENNAISFVVESSFRDWNTN 76
            |:|||...|.......:.:..|.:..:.| .|.:|  ..|.::|..|:..::.:.|.:..:  ..
Zfish    48 SSLHGINHIFVSGRLGVRQTLWALAFLVS-LALFLYQAAKCAISYLEHPHVTALNEEATPE--MV 109

  Fly    77 FPAIIVCESKNMDRIQEVAEQLWGADHDFTLEEVLSEIAFFRGESYHTV------------HECS 129
            |||:.:|   |::|.:..|  |..||                  .||..            |:.:
Zfish   110 FPAVTIC---NINRFRFSA--LTDAD------------------IYHLANLTGLPPKNKDGHKPT 151

  Fly   130 GEEVTA---SCFYSNFSYYAELVRSSCVDSISNCEWNNKPFECCKYFHRMETELGICYAINSMQA 191
            ..|..|   ...::...:..|.:..||..|..||.        .:.|..:.|..|.||..|..:.
Zfish   152 DLEYPAPDMQDIFNRTGHQLEEMLKSCNFSGQNCS--------AEDFTVVYTRYGKCYTFNGNKT 208

  Fly   192 GKPKMPKLNM--------------------YSNRGSGPGALKMELHTEATVFILGTEEVPTL--- 233
            ...|..:..|                    .:|..|....:::::|::        :|.|.:
Zfish   209 TSRKTKQGGMGNGLEIMLDIQQDDYLPIWKETNETSLEAGIRVQIHSQ--------DEPPYIHQL 265

  Fly   234 ---VTPKTDFLVVGPYISFVRYISKRDIENDEEIRQTSVHQ--RNCRFADENILDVHKFYSYSAC 293
               |:|           .|..::|      .:|.|.|.:.|  .|||...|.::..:..||.|||
Zfish   266 GFGVSP-----------GFQTFVS------CQEQRLTYLPQPWGNCRSTSEQMIPGYDTYSISAC 313

  Fly   294 TVQCRKDRQMELCNCSSHLSPNSPDWQLCNMEGLECLNRNYEDLSVIIAKWSKLRGRKGLVCDCL 358
            .::|.....:..|.|.....|.  |..:|....::|:::          ..:.|:...|..|.|.
Zfish   314 RLRCETLEVLRECKCRMVHMPG--DANICTPSDIKCVDK----------ALALLQKSSGDTCFCE 366

  Fly   359 PSCTEVDITTVYDSKENMA-----GSQNAISR---------------IEVGLIELPTERYKRNLV 403
            ..|.    .|.|..:.:|.     ||...:||               :::....|..|..::...
Zfish   367 TPCN----LTRYGKELSMVKIPSKGSARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKKA 427

  Fly   404 RGKLDLVVSIGGTTGLFVGASLLSFVEIFYYITIRPYTTYINEKRRLKRLIIPKR 458
            .....|:..|||..|||:|||:|:.:||..|:       |...|.||:||:.|:|
Zfish   428 YDVAGLLGDIGGQMGLFIGASVLTILEILDYV-------YEVIKHRLERLLRPQR 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:279230	98/484 (20%)
asic4a	NP_999952.1	ASC	44..472	CDD:295594	105/505 (21%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950