DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk13 and ASIC2

DIOPT Version :9

Sequence 1:	NP_001014495.1	Gene:	ppk13 / 3346226	FlyBaseID:	FBgn0053508	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_899233.1	Gene:	ASIC2 / 40	HGNCID:	99	Length:	563	Species:	Homo sapiens

Alignment Length:	496	Identity:	118/496 - (23%)
Similarity:	186/496 - (37%)	Gaps:	122/496 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LKNSTLHGARFI----VDKDASWIERIFWVIC------LVASWYASWLLIKASLSAFENNAISFV 65
            |..:.|||.|.:    .....|:..|..||:.      |:.||.::.||...|..:...
Human    61 LSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTR------ 119

  Fly    66 VESSFRDWNTN--FPAIIVCESKNMDRIQEVAE-QLWGADH-------DFTLEEVLSEIAFFRGE 120
               ..|:|:..  |||:.|| :.|..|...::: .|:.|.|       :.|...::||:  .||:
Human   120 ---VHREWSRQLPFPAVTVC-NNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSEL--LRGD 178

  Fly   121 -----------SYHTVHECSGEEVTASCFYSNFSYYAELVRSSCVDSISNCEWNNKPFECC--KY 172
                       .:.........|..::.|.....:..|       |.:.:|::..   |.|  ..
Human   179 EPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLE-------DMLLSCKYRG---ELCGPHN 233

  Fly   173 FHRMETELGICYAINSMQAGKPKMPKLNMYSNRGSGPGALKMEL------------HTEATVFIL 225
            |..:.|:.|.||..||.:.|||.:..:    ..|:|.| |::.|            .||.|.|..
Human   234 FSSVFTKYGKCYMFNSGEDGKPLLTTV----KGGTGNG-LEIMLDIQQDEYLPIWGETEETTFEA 293

  Fly   226 G------TEEVPTLVTPKTDFLVVGPYISFVRYISKRDIENDEEIRQTSVHQ--RNCRFADENIL 282
            |      ::..|..: .:..|.|...:.:||.         .:|.|.|.:..  ..|| :.|..|
Human   294 GVKVQIHSQSEPPFI-QELGFGVAPGFQTFVA---------TQEQRLTYLPPPWGECR-SSEMGL 347

  Fly   283 DVHKFYSYSACTVQCRKDRQMELCNCSS-HLSPNSPDWQLCNME----------GL-------EC 329
            |....||.:||.:.|.....:|.|||.. |:..::|   .|..|          ||       .|
Human   348 DFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAP---FCTPEQHKECAEPALGLLAEKDSNYC 409

  Fly   330 LNRNYEDLSVIIAKWSKLRGRKGLVCDCLPSCTEVDITTVYDSKENMAGSQNAISRIEVGLIELP 394
            |.|...:|:         |..|.|....:||.|.........:|.....|:| |..:::....|.
Human   410 LCRTPCNLT---------RYNKELSMVKIPSKTSAKYLEKKFNKSEKYISEN-ILVLDIFFEALN 464

  Fly   395 TERYKRNLVRGKLDLVVSIGGTTGLFVGASLLSFVEIFYYI 435
            .|..::........|:..|||..|||:|||:|:.:|:|.||
Human   465 YETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:279230	116/493 (24%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	117/493 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870