DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk13 and ASIC2

DIOPT Version :10

Sequence 1:NP_001014495.1 Gene:ppk13 / 3346226 FlyBaseID:FBgn0053508 Length:460 Species:Drosophila melanogaster
Sequence 2:NP_899233.1 Gene:ASIC2 / 40 HGNCID:99 Length:563 Species:Homo sapiens


Alignment Length:496 Identity:118/496 - (23%)
Similarity:186/496 - (37%) Gaps:122/496 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LKNSTLHGARFI----VDKDASWIERIFWVIC------LVASWYASWLLIKASLSAFENNAISFV 65
            |..:.|||.|.:    .....|:..|..||:.      |:.||.::.||...|..:...      
Human    61 LSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTR------ 119

  Fly    66 VESSFRDWNTN--FPAIIVCESKNMDRIQEVAE-QLWGADH-------DFTLEEVLSEIAFFRGE 120
               ..|:|:..  |||:.|| :.|..|...::: .|:.|.|       :.|...::||:  .||:
Human   120 ---VHREWSRQLPFPAVTVC-NNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSEL--LRGD 178

  Fly   121 -----------SYHTVHECSGEEVTASCFYSNFSYYAELVRSSCVDSISNCEWNNKPFECC--KY 172
                       .:.........|..::.|.....:..|       |.:.:|::..   |.|  ..
Human   179 EPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLE-------DMLLSCKYRG---ELCGPHN 233

  Fly   173 FHRMETELGICYAINSMQAGKPKMPKLNMYSNRGSGPGALKMEL------------HTEATVFIL 225
            |..:.|:.|.||..||.:.|||.:..:    ..|:|.| |::.|            .||.|.|..
Human   234 FSSVFTKYGKCYMFNSGEDGKPLLTTV----KGGTGNG-LEIMLDIQQDEYLPIWGETEETTFEA 293

  Fly   226 G------TEEVPTLVTPKTDFLVVGPYISFVRYISKRDIENDEEIRQTSVHQ--RNCRFADENIL 282
            |      ::..|..: .:..|.|...:.:||.         .:|.|.|.:..  ..|| :.|..|
Human   294 GVKVQIHSQSEPPFI-QELGFGVAPGFQTFVA---------TQEQRLTYLPPPWGECR-SSEMGL 347

  Fly   283 DVHKFYSYSACTVQCRKDRQMELCNCSS-HLSPNSPDWQLCNME----------GL-------EC 329
            |....||.:||.:.|.....:|.|||.. |:..::|   .|..|          ||       .|
Human   348 DFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAP---FCTPEQHKECAEPALGLLAEKDSNYC 409

  Fly   330 LNRNYEDLSVIIAKWSKLRGRKGLVCDCLPSCTEVDITTVYDSKENMAGSQNAISRIEVGLIELP 394
            |.|...:|:         |..|.|....:||.|.........:|.....|:| |..:::....|.
Human   410 LCRTPCNLT---------RYNKELSMVKIPSKTSAKYLEKKFNKSEKYISEN-ILVLDIFFEALN 464

  Fly   395 TERYKRNLVRGKLDLVVSIGGTTGLFVGASLLSFVEIFYYI 435
            .|..::........|:..|||..|||:|||:|:.:|:|.||
Human   465 YETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYI 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk13NP_001014495.1 ASC 10..434 CDD:459966 116/493 (24%)
ASIC2NP_899233.1 ENaC 64..547 CDD:273304 117/493 (24%)

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