DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk13 and Scnn1a

DIOPT Version :9

Sequence 1:	NP_001014495.1	Gene:	ppk13 / 3346226	FlyBaseID:	FBgn0053508	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_113736.1	Gene:	Scnn1a / 25122	RGDID:	3639	Length:	699	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	113/567 - (19%)
Similarity:	187/567 - (32%)	Gaps:	188/567 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FSRVIEEYLKNSTLHGARFIVDKDASWIERIFWVI---CLVASWYASWLLIKASLSAFENNAISF 64
            :..:.:.:..|:|:|||..:|....:.::..||.:   |.....|..:.|:      || ..:|:
  Rat    81 YRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALL------FE-EYLSY 138

  Fly    65 VVESSFRDWNTN-----FPAIIVCESKNMDRIQEVAEQLWGADHDFTLEEVLSEIAFFRGESY-- 122
            .|..:.   |.|     |||:.|| :.|..|..|:.|:|  .:.|...|:.|.:: :....||
  Rat   139 PVSLNI---NLNSDKLVFPAVTVC-TLNPYRYTEIKEEL--EELDRITEQTLFDL-YKYNSSYTR 196

  Fly   123 -----------------HTVHEC-------------SG-----------------------EEVT 134
                             |.:...             ||                       .:..
  Rat   197 QAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQNK 261

  Fly   135 ASCFYSNFSYYAELVR-----------SSCVDS------------ISNCEWNNKPFEC-----CK 171
            :.|||..:|...:.||           |...|:            |..|.:|..|  |     .|
  Rat   262 SDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEALGNFIFTCRFNQAP--CNQANYSK 324

  Fly   172 YFHRMETELGICYAINSMQAGK---PKMPKLNMYSNRGSGPGALKMELHTEATVFILGTEEVPTL 233
            :.|.|   .|.||..|......   ..||.:|         ..|.:.|.||...||      |.|
  Rat   325 FHHPM---YGNCYTFNDKNNSNLWMSSMPGVN---------NGLSLTLRTEQNDFI------PLL 371

  Fly   234 VTPKTDFLVVGPYI--------SFV---RYISKRDIENDEEIRQTSVHQRNCRFAD--ENILDV- 284
            .|      |.|..:        :|:   .:..:..:|....:|:.::......:.|  ||..||
  Rat   372 ST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTENGSDVP 430

  Fly   285 -----HKFYSYSACTVQCRKDRQMELCNCSSHLSP-----------NSPDWQLC--------NME 325
                 ...|:...|...|.::..::.|.|:....|           ....|..|        :::
  Rat   431 VKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYRKQSSWGYCYYKLQGAFSLD 495

  Fly   326 GLECLNRNYEDLSVIIAKWSKLRGRKGLVCDCLPSCTEVDITTVYDSKEN---MAGSQNAISRIE 387
            .|.|.::..:..|||..|.|....|       .||....|......|.:|   :...:|.::::.
  Rat   496 SLGCFSKCRKPCSVINYKLSAGYSR-------WPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLN 553

  Fly   388 VGLIELPTERYKRNLVRGK---LDLVVSIGGTTGLFVGASLLSFVEI 431
            :...||   .||.|.....   :.|:.::|....|:.|:|:||.||:
  Rat   554 IFFKEL---NYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEM 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:279230	113/560 (20%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	113/567 (20%)
Scnn1a	NP_113736.1	deg-1	88..600	CDD:273309	113/560 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820