DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk13 and Asic1

DIOPT Version :9

Sequence 1:	NP_001014495.1	Gene:	ppk13 / 3346226	FlyBaseID:	FBgn0053508	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001276720.1	Gene:	Asic1 / 11419	MGIID:	1194915	Length:	559	Species:	Mus musculus

Alignment Length:	506	Identity:	109/506 - (21%)
Similarity:	185/506 - (36%)	Gaps:	126/506 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVIEEYLKNSTLHGARFIVDKDASWIERIFWVICLV-------------ASWYASWLLIKASLSA 56
            |.:..:..:.|||||..:..:......:..|.:..|             .::|.|:    ..::.
Mouse    61 RDLVAFANSCTLHGASHVFVEGGPGPRQALWAVAFVIALGAFLCQVGDRVAYYLSY----PHVTL 121

  Fly    57 FENNAISFVVESSFRDWNTNFPAIIVCESKNMDRIQEVA-------EQLWGADHDFTLEEVLSEI 114
            .:..|.:.:|          |||:..|.: |..|:.:::       ..:.|.|..   ::....:
Mouse   122 LDEVATTELV----------FPAVTFCNT-NAVRLSQLSYPDLLYLAPMLGLDES---DDPGVPL 172

  Fly   115 AFFRGESYHTVHECSGEEVTASCFYSNFSYYAELVRSSCVDSISNCEWNNKPFECCKY-FHRMET 178
            |....|::      |||......||:...:..|       |.:..|.:...|  |..: |..:.|
Mouse   173 APPGPEAF------SGEPFNLHRFYNRSCHRLE-------DMLLYCSYCGGP--CGPHNFSVVFT 222

  Fly   179 ELGICYAINSMQAGKPKMPKLNMYSNRGSGPGALKMEL------------HTEATVFILG----- 226
            ..|.||..||.|.|:|::..:    ..|:|.| |::.|            .|:.|.|..|
Mouse   223 RYGKCYTFNSGQDGRPRLKTM----KGGTGNG-LEIMLDIQQDEYLPVWGETDETSFEAGIKVQI 282

  Fly   227 -TEEVPTLVTPKTDFLVVGPYISFVRYISKRDIENDEEIRQTSVHQR-----------NCRFADE 279
             :::.|    |..|.|..|....|..::|.::             ||           |....|.
Mouse   283 HSQDEP----PFIDQLGFGVAPGFQTFVSCQE-------------QRLIYLPSPWGTCNAVTMDS 330

  Fly   280 NILDVHKFYSYSACTVQCRKDRQMELCNCSS-HLSPNSP-----DWQLCNMEGLECLNRNYEDLS 338
            :..|   .||.:||.:.|.....:|.|||.. |:..::|     .::.|....|:.|....::..
Mouse   331 DFFD---SYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYC 392

  Fly   339 VIIAKWSKLRGRKGLVCDCLPSCTEVD-ITTVYDSKENMAGSQNAISRIEVGLIELPT-ERYKRN 401
            |.....:..|..|.|....:||..... :...::..|...|....:..|...::...| |:.|..
Mouse   393 VCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAY 457

  Fly   402 LVRGKLDLVVSIGGTTGLFVGASLLSFVEIFYYITIRPYTTYINEKRRLKR 452
            .:.|   |:..|||..|||:|||:|:.:|:|.|       .|...|.||.|
Mouse   458 EIAG---LLGDIGGQMGLFIGASILTVLELFDY-------AYEVIKHRLCR 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk13	NP_001014495.1	ASC	10..434	CDD:279230	102/481 (21%)
Asic1	NP_001276720.1	ASC	63..541	CDD:295594	108/504 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950