DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and ddr2l

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_001072499.1	Gene:	ddr2l / 779954	XenbaseID:	XB-GENE-5884186	Length:	879	Species:	Xenopus tropicalis

Alignment Length:	992	Identity:	336/992 - (33%)
Similarity:	483/992 - (48%)	Gaps:	172/992 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 AAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHM 154
            |.:......|.:| .:|:.||||....|.|..|.|||.. ..:.|||:|||:.:...|||||..:
Frog     9 ALLSGRAKCAVIP-ASCRYALGMHDRTIRDEDIIASSQW-YESTGPQYARLQREEGDGAWCPAGL 71

  Fly   155 VSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLP 219
            :.....:|||:||..:|.::.|.||||..:..|:|:..||.::|.|.| .:|:.||..||::|:.
Frog    72 LQPEDVQYLQIDLHELHFITLIGTQGRHARATGKEFARAYRVDYSRNG-GRWLSWRDHQGQQVMR 135

  Fly   220 GNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKG---MQRGM 281
            ||::.|..|...|:|.:.|..:|:.|.::...|||:|.|:.||.|.:|:.|||:|:|   :..|.
Frog   136 GNVDEYEVVLADLRPPIIARYIRVIPVTKVPMTVCMRVELYGCKWSDGLTSYSVPEGETYIAPGQ 200

  Fly   282 DID-LSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNFRADIN-GLGKGYEWIGWRNDTLLGRPVEI 344
            .|. |:|.|||||.|......|||||.||..|.|:|...:. .:..||::||||||:.....||:
Frog   201 PIAFLNDSTYDGYLEKRRQFGGLGQLTDGIHGLDDFTQSLQYRVWPGYDYIGWRNDSAPRGYVEV 265

  Fly   345 IFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFS--IGGRHFSGEPVQFSYMPDLVLDHARDV 407
            .|.|:..||.|.:.:|.||:|||.|::|..|:..|.  :.| .:..|||....:.|.....||.|
Frog   266 EFHFDRPRNFSLMKVHCNNLFSKGVKIFQKAECLFKPRLEG-EWEAEPVVVLMVVDDKNPSARFV 329

  Fly   408 TIKLHHRLGRYVQLHLYFAARWMMISEITF-----ISAPVVGNFTDELANGEKQSVTSEYPLQRD 467
            ||.|..|:|..:....|||..|||.|||:|     |:.|.:|.          ||.||. |.|..
Frog   330 TIPLRQRVGSAILCRFYFADAWMMFSEISFESDMGIAVPTLGT----------QSPTSA-PAQTT 383

  Fly   468 EVGRAISSGGERSQHTT--QVISPKPIDHQEPETSFVGVIITVLGTIIMLLVAFILLIVARNKHV 530
            ||..|:.:..||...||  ..||...::..|..||   |:|..|..||:|||..|:||:.: ::|
Frog   384 EVPVALQNSTERKLETTFPFTISRPVVNPPESRTS---VLIGCLVAIILLLVLVIVLILWK-QYV 444

  Fly   531 RSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMN-- 593
            :.|                    :.|....:.:.:::: :.|.|......:..|....:.|..
Frog   445 QKR--------------------LEKAPRRILEEDATV-RLSFYSYTIGNSQQTQIHQSNPTYER 488

  Fly   594 ----DLQRQHVSPDYTDVP-------DIVCQ-DYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGS 646
                ||..|..:.....:|       |..|. |||.|.:                 |.:.|.:|
Frog   489 IFPLDLDYQQPTKPLRKLPELSQSAEDSACSGDYAEPDL-----------------TKSTPHQG- 535

  Fly   647 SPEFVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSS 711
                          .:||            ||     :||.|.:      |:..|...:...:..
Frog   536 --------------FQNS------------VP-----HYAETDI------VSLQGVTGNNMYAVP 563

  Fly   712 TTAATTPTSGVVGVGKPHHYNLDMSANFADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLC 776
            .....:.|...:.||                          ||||..|.:.||||.|.|||:|||
Frog   564 AVTVDSLTKKDITVG--------------------------EFPRNQLRLKEKLGEGQFGEVHLC 602

  Fly   777 ETNVL-------------NATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRD 828
            |...|             ...:|||..|||......|.:|..:.|.:::|..||:.||:|.|:||
Frog   603 EAEGLQEFLEMSPNEFSDQPNMVAVKMLRPDVTKTARNDFLKEIKIISRLKHPNIIRLLGVCVRD 667

  Fly   829 EPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKK--SLSFGCLVYIATQIASGMKHLEQMNFVHR 891
            :|:|::.:|.. .|||||||.:....:....|..  |:|...|:|:|.|||:|||:|..:|||||
Frog   668 DPLCMITEYME-NGDLNQFLSQREIRSQFTKANNIPSVSRQNLLYMAAQIAAGMKYLASLNFVHR 731

  Fly   892 DLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTK 956
            |||||:|::|....:||...|  ::|:.|:.||.:::|     ...:|||||||||:|||||||.
Frog   732 DLATRNCLVGNSYTIKVADFG--MSRNLYSGDYYRIQG-----RAVLPIRWMAWESILLGKFTTC 789

  Fly   957 SDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECW 1021
            ||.|:|.|.|||:.:..:||||..|:|:.||||.|..:||......|...|.||..:::||..||
Frog   790 SDAWAFGVTLWEMFSLCKEQPYSVLTDEQVIENTGEFFRDQGRQIYLSQTPLCPGPVFELMMRCW 854

  Fly  1022 QRDESSRPSFREIHLYL 1038
            .||...||:|..||.:|
Frog   855 SRDIKDRPTFETIHHFL 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	60/155 (39%)
		FA58C	109..261	CDD:238014	59/151 (39%)
		PTKc_DDR	753..1040	CDD:270644	132/301 (44%)
		TyrKc	759..1038	CDD:197581	127/293 (43%)
ddr2l	NP_001072499.1	FA58C	26..177	CDD:238014	59/152 (39%)
ddr2l	NP_001072499.1	PTKc_DDR_like	579..873	CDD:133228	132/301 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1800
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	525	1.000	Inparanoid score	I1217
OMA	1	1.010	-	-		QHG45751
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm9464
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4211
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110