DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and Ddr2

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_113952.2	Gene:	Ddr2 / 685781	RGDID:	619855	Length:	854	Species:	Rattus norvegicus

Alignment Length:	1003	Identity:	329/1003 - (32%)
Similarity:	474/1003 - (47%)	Gaps:	193/1003 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LTLTLILLANRFGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDM 130
            |.|.|:||.    :|:|               .|::....|:..|||..|.|.|..|||||...
  Rat     9 LVLLLLLLI----LGSA---------------KAQVNPAICRYPLGMSGGHIPDEDITASSQWS- 53

  Fly   131 GNVGPQHARLKIDNNGGAWCPKHMVS-RGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAY 194
            .:...::.||..:...|||||:..|. ..|.|:||:||..:|.::.:.||||...|.|.|:...|
  Rat    54 ESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMY 118

  Fly   195 VIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEI 259
            .|.|.|.| .:||.||:..||:||.||.|.|......|:|.:.|..|||.|.:.:...||:|.|:
  Rat   119 KINYSRDG-NRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVEL 182

  Fly   260 VGCAWEEGIVSYSIPKGMQ----RGMDIDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNF-RAD 319
            .||.|.:|:|||:.|.|.|    .|..|.|:|..||| ..|.....|||||.||..|.|:| :..
  Rat   183 YGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGVSGLDDFTQTH 246

  Fly   320 INGLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGR 384
            ...:..||:::||||::.....:||:|||:.|||.:.:.:|.||||:|.|::|...:.:|.....
  Rat   247 EYHVWPGYDYVGWRNESATNGFIEIMFEFDRVRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSETS 311

  Fly   385 HFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFTDE 449
            .:....|.|..:.|.|...||.||:.||||:...::...:||..|||.|||||.|...:.|.:..
  Rat   312 EWEPTAVYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGA 376

  Fly   450 LANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEPETSFVGVIITVLGTIIM 514
            |........|.:..|:.|:                               |...::|..|..||.
  Rat   377 LPTSPMAPTTFDPMLKVDD-------------------------------SNTRILIGCLVAIIF 410

  Fly   515 LLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFN 579
            :|:|.|::|:.|....:..|                     |....|.|:|.::..:.    |..
  Rat   411 ILLAVIVIILWRQFWQKMLE---------------------KASRRMLDDEMTVSLSL----PSE 450

  Fly   580 ANMYTSAASACPMNDLQRQ------HVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCG---SGCG 635
            ::|:.:..|:.|.......      .:.|||.:...::          :.||...| |   |||
  Rat   451 SSMFNNNHSSSPSEQESNSTYDRIFPLRPDYQEPSRLI----------RKLPEFAP-GEEESGC- 503

  Fly   636 TGTGTGPGRGSSPEFVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPP 700
                              :|.|.              |:.|..|....:||...:.:
  Rat   504 ------------------SGVVK--------------PAQPNGPEGVPHYAEADIVN-------- 528

  Fly   701 GSQSSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADINEERANCQVQEFPRQSLVIVEKL 765
               ..|....:|.:....|..::. ||                    :..|:||||:.|...|||
  Rat   529 ---LQGVTGGNTYSVPAVTMDLLS-GK--------------------DVAVEEFPRKLLAFKEKL 569

  Fly   766 GSGVFGELHLCETNVL---------------NATLVAVATLRPGANDHLRKEFRSKAKQLAQLSD 815
            |.|.|||:||||...:               ...||||..||..||.:.|.:|..:.|.:::|.|
  Rat   570 GEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKD 634

  Fly   816 PNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGM 880
            .|:.||:..|:.::|:|::.:|.. .|||||||..|...:|| .:..::|:..|.::||||||||
  Rat   635 ANIIRLLAVCITEDPLCMITEYME-NGDLNQFLSRHEPLSSG-SSNATVSYANLKFMATQIASGM 697

  Fly   881 KHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAW 945
            |:|..:||||||||||:|::|....:|:...|  ::|:.|:.||.:::|     ...:|||||:|
  Rat   698 KYLSSLNFVHRDLATRNCLVGKNYTIKIADFG--MSRNLYSGDYYRIQG-----RAVLPIRWMSW 755

  Fly   946 ESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCP 1010
            ||:|||||||.||||:|.|.|||..||.:||||..|||:.||||.|..:||......||.|..||
  Rat   756 ESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPAVCP 820

  Fly  1011 REIYDLMCECWQRDESSRPSFREIHLYL 1038
            ..:|.||..||:|:...||||:||||.|
  Rat   821 DSVYKLMLSCWRRETKHRPSFQEIHLLL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	62/156 (40%)
		FA58C	109..261	CDD:238014	61/152 (40%)
		PTKc_DDR	753..1040	CDD:270644	138/301 (46%)
		TyrKc	759..1038	CDD:197581	133/293 (45%)
Ddr2	NP_113952.2	FA58C	32..184	CDD:238014	61/153 (40%)
Ddr2	NP_113952.2	PKc_like	557..850	CDD:419665	138/301 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1844
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68505
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1204
OMA	1	1.010	-	-		QHG45751
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm9045
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980