Protein Alignment Ddr and Epha8

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_001406194.1
• Gene: Epha8 / 60589
• RGDID: 708543
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 695
• Identity: 159/695 - (22%)
• Similarity: 246/695 - (35%)
• Gaps: 235/695 - (33%)

  Fly   439 SAPVVGNFTDELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVI---SPKPIDHQE---- 496
            ||||  |....: ||  .|||.|:....|.        |.||..|...:   .|..:.|.|
  Rat   329 SAPV--NLISSV-NG--TSVTLEWAPPLDP--------GGRSDITYNAVCRRCPWALSHCEACGS 380

  Fly   497 ------PETSFVGVIITVLGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPD-------- 547
                  .:||.....:.|...:..:..:|.:..|          ||:.    |.||:
  Rat   381 GTRFVPQQTSLAQASLLVANLLAHMNYSFWIEAV----------NGVS----NLSPEPRNAAVVN 431

  Fly   548 -TLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIV 611
             |.|.....:||....:.......:.|:.||                            :.|:.:
  Rat   432 ITTNQAAPSQVVVIRQERAGQTSVSLLWQEP----------------------------EQPNGI 468

  Fly   612 CQDYAVPH------------MQQLLPNAPPCGSGCGT--------GTGTGPGRGSSPEFVVATGK 656
            ..:|.:.:            ::.:...|...|...||        .|..|.|| .|....|.|||
  Rat   469 ILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYMFQVRARTSAGCGR-FSQAMEVETGK 532

  Fly   657 VTASARNSLNAATLPLPSPPVPPPLEKYYAATPV------------------------------- 690
                                   |..:|...|.|
  Rat   533 -----------------------PRPRYDTRTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQ 574

  Fly   691 -----------SSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADINE 744
                       ...|.||..|.:...|.|..:..:|           :||:|            |
  Rat   575 DSDEEKMHYQNGQAPPPVFLPLNHPPGKLPETQFSA-----------EPHNY------------E 616

  Fly   745 E--RANCQVQEFPRQ---SLVIVEK-LGSGVFGELHLCETNV--LNATLVAVATLRPGANDHLRK 801
            |  ||.   :.|.|:   |.:.:|| :|||..||:......|  .....||:..|:.|..:..|:
  Rat   617 EPGRAG---RSFTREIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQ 678

  Fly   802 EFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSF 866
            :|..:|..:.|...||:.||.|...|.....||.:|.. .|.|:.||:.|..:.:.|.
  Rat   679 DFLREAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYME-NGSLDAFLRTHDGQFTILQ------- 735

  Fly   867 GCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINR-------SAYASDY 924
              ||.:...:.:||::|..:.::|||||.|:.::...|..||...|  ::|       :||.:
  Rat   736 --LVGMLKGVGAGMRYLSDLGYIHRDLAARNILVDGRLVCKVSDFG--LSRALEDDPEAAYTT-- 794

  Fly   925 CQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIEN 989
                     ....:||||.|.|::....|::.||||||.|.:||:|.:. |:||.:::::.||.:
  Rat   795 ---------AGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYG-ERPYWNMTNQDVISS 849

  Fly   990 IGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
            :...||       ||.|..|||.::.||.:||.:|.:.||.|..:
  Rat   850 VEEGYR-------LPAPMGCPRALHQLMLDCWHKDRAQRPRFSHV 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	90/295 (31%)
Epha8	NP_001406194.1	EphR_LBD	30..202	CDD:470656
		FN3	<325..>518	CDD:442628	43/243 (18%)
		FN3	439..530	CDD:238020	17/119 (14%)
		EphA2_TM	<561..631	CDD:464211	16/95 (17%)
		Protein Kinases, catalytic domain	629..895	CDD:473864	88/290 (30%)
		SAM_EPH-A8	932..994	CDD:188949