DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and smal

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_723165.2	Gene:	smal / 5740323	FlyBaseID:	FBgn0085409	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	770	Identity:	410/770 - (53%)
Similarity:	503/770 - (65%)	Gaps:	130/770 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SIYSRSEC-----------SPTIGVPALVESQGGEGHESRRPATNYLKSYCRIKRHGVNNSKTLC 64
            |::|| :|           :||...|              ||.       ||..|.      |||
  Fly    16 SMFSR-QCLSHLTRSPPTTTPTAAAP--------------RPP-------CRAPRW------TLC 52

  Fly    65 WLTLTL---ILLANRFGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASS 126
            ..||.:   .|:.|         .|.|.|          ..|.||...|||||..|.|.||||||
  Fly    53 LWTLVIASGCLMLN---------APTTMA----------FDIATCNVPLGMESLLITDAQITASS 98

  Fly   127 AHDMGNVGPQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYT 191
            ||||..|||||||||.||:|||||||||||..|.||||||||..|:::|||||||:|||||||||
  Fly    99 AHDMAFVGPQHARLKTDNDGGAWCPKHMVSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGQEYT 163

  Fly   192 EAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLR 256
            ||||:||||||..||.||:::||||:|||||||||||||.|||.:||||:|:|||.|||||||||
  Fly   164 EAYVLEYWRPGFDKWQRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRTVCLR 228

  Fly   257 AEIVGCAWEEGIVSYSIPKGMQRGMDIDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNFRADIN 321
            ||||||.|||||||||||||:||||::|||||||||.|:||.||:|||||||||:||||||.||:
  Fly   229 AEIVGCPWEEGIVSYSIPKGVQRGMEVDLSDKTYDGNEQGDRYVDGLGQLVDGQKGKDNFRTDIH 293

  Fly   322 GLGKGYEWIGWRNDT--LLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGR 384
            |.|||||||||||||  |||:||||:|||:||||.||:::||||||:||||||||||||||||||
  Fly   294 GFGKGYEWIGWRNDTPGLLGKPVEIVFEFDTVRNFSAIVLHTNNMFTKDVQVFVHAKVFFSIGGR 358

  Fly   385 HFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFTDE 449
            :|||||||||||||.::|||||||||||||:|:|::::||||.:|:|:|||:|||.|.:||||||
  Fly   359 YFSGEPVQFSYMPDTIMDHARDVTIKLHHRVGKYLKINLYFAVKWIMLSEISFISVPAMGNFTDE 423

  Fly   450 ---LANGEKQSVT-------SEYPLQRDE----------VGRAISS------GGERSQHTTQVIS 488
               .:|...|:..       |||...|::          :|..:::      |..:..:..|:|:
  Fly   424 QEQRSNSPSQAQDVHDETNGSEYQANRNKPNGVGGSAGGLGEGVAAAGGDIVGNNKYNNGPQLIA 488

  Fly   489 PKPIDHQEPETSFVGVIITVLGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNG 553
            |:|||.:..:.:|:||:|.||.|||:||||.||.||:|.|..|. .|.|||||::|:|:||.||
  Fly   489 PRPIDQEPNDANFIGVVIVVLTTIIILLVAIILFIVSRTKRARG-SNVLDAFQYSFNPNTLGGN- 551

  Fly   554 VLK-------VVTTMDDNESSIDKNSLYHEPFNANMYTSAASA-CPMNDLQRQHVSPDYTDVPDI 610
            |.|       :...:|||: ||.||||||||||.||||...:. ..:|||| .:::|||||||:
  Fly   552 VDKHRPNGNSIKANVDDND-SIGKNSLYHEPFNVNMYTCGVNGYAAVNDLQ-CNMTPDYTDVPE- 613

  Fly   611 VCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTASARNSLNAATLPLPSP 675
              ..|||||||..:|::...|...|.|......|...|..                ::..|.|..
  Fly   614 --GGYAVPHMQDYMPSSKMGGGAPGGGGYVNVRRTPPPPL----------------SSIFPRPPT 660

  Fly   676 PVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPHH 730
            ..|||:|||||.|.:..   |:..|||:.||..|::.|.::       |.||..|
  Fly   661 VPPPPMEKYYATTAIFK---PLKGPGSERSGCSSNTNTVSS-------GGGKSSH 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	121/155 (78%)
		FA58C	109..261	CDD:238014	119/151 (79%)
		PTKc_DDR	753..1040	CDD:270644
		TyrKc	759..1038	CDD:197581
smal	NP_723165.2	FA58C	78..234	CDD:214572	121/155 (78%)
smal	NP_723165.2	FA58C	81..233	CDD:238014	119/151 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3782
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68505
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1210
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm6449
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R14052
SonicParanoid	1	1.000	-	-		X998
	11	11.000