Protein Alignment Ddr and ddr2b

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: XP_017206819.2
• Gene: ddr2b / 559428
• ZFINID: ZDB-GENE-060503-361
• Length: 838
• Species: Danio rerio
• Alignment Length: 993
• Identity: 321/993 - (32%)
• Similarity: 465/993 - (46%)
• Gaps: 196/993 - (19%)

  Fly    77 FGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDMGNVGPQHARLK 141
            ||   ||.:...||              .|:..|||..|.|.|..|:|||... .:...::.||.
Zfish    14 FG---AVNSQVNPA--------------VCRYPLGMNGGQIQDEDISASSQWS-ESTAARYGRLD 60

  Fly   142 IDNNGGAWCPKHMV-SRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKK 205
            .|:..|||||..|. :..|.|:||:||..:|.|:.:.||||...|.|.|:.:.|.|:|.|.| .:
Zfish    61 FDDGDGAWCPDVMAEAHSLKEFLQIDLRTLHFVTLVGTQGRHADGVGNEFAQRYRIKYSRDG-TR 124

  Fly   206 WIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVS 270
            |:.||..||::::.||.|.|..|...|:|.:.|..||..|.:.....||:|.|:.||.|.:|:||
Zfish   125 WVSWRDRQGRQIIEGNSNAYDIVLKDLEPPIIARFVRFMPVTDPSMIVCMRVELYGCEWLDGLVS 189

  Fly   271 YSIPKGMQ---RGMDIDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNF-RADINGLGKGYEWIG 331
            ||.|.|.|   ||..|.|:|..||| ........|||||.||..|.|:| ::.:.|:..||:::|
Zfish   190 YSAPAGQQMTFRGQQIYLNDTVYDG-AVSSSMAEGLGQLTDGSWGLDDFTKSQVYGVWPGYDYVG 253

  Fly   332 WRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYM 396
            |.|.:|.|..||:.|||:.|||.:::.:|.|||::..|::|..|...|. ....:...||.|...
Zfish   254 WTNASLPGGSVEMTFEFDRVRNFTSMKVHCNNMYAWGVKMFRQAVCSFR-SDADWEPNPVFFKPK 317

  Fly   397 PDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFTDELANGEKQSVTSE 461
            .|.:...||.:|:.|.:|:...::....|:..|||.|||.|.|...|.|             ||.
Zfish   318 ADSISPSARFITVALGNRMASAIRCRFAFSDIWMMFSEIAFQSDTAVYN-------------TSL 369

  Fly   462 YPLQRDEVGRAISSGGERSQHTTQVISPKPID---HQEPETSFVGVIITVLGTIIMLLVAFILLI 523
            .|.:|::.                     |:|   |:..::| ..::|..|..||.:|:|.|::|
Zfish   370 VPRKRNQA---------------------PVDDPTHKIDDSS-TRILIGCLVAIIAILLAIIIII 412

  Fly   524 VARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNE----SSIDKNSLYHEPFNANMYT 584
            :.|....:..|                     |....|.|:|    .|:.:.:..|.       :
Zfish   413 LWRQVWQKMIE---------------------KASRRMLDDELAVRLSVQREAFVHR-------S 449

  Fly   585 SAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPE 649
            |:.|:...:....:.:.|        :..||..|  .|||...                    ||
Zfish   450 SSLSSDVESTSTYERIFP--------LGSDYQEP--SQLLRKL--------------------PE 484

  Fly   650 FVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTA 714
            |............:.        |||........:||...:         ||:.     |...|.
Zfish   485 FQAMENLAMIDGASE--------PSPAQGTDEAPHYAEADI---------PGAH-----SYRVTV 527

  Fly   715 ATTPTS-GVVGVGKPHHYNLDMSANFADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCET 778
            ...|.| |..|.                         ::||||..|...||||.|.|||:||||.
Zfish   528 VNMPLSPGRDGA-------------------------LEEFPRDRLTFKEKLGEGQFGEVHLCEA 567

  Fly   779 N-------------VLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEP 830
            .             .::..||||.|||..|:.:.|.:|..:.:.:::|.|||:.||:..|:..:|
Zfish   568 EGMQEFMKDHCDDICVDPMLVAVKTLREDADKNARNDFMKEIRIISRLRDPNIIRLLAVCVESDP 632

  Fly   831 ICIVQDYSHCLGDLNQFLQEHVAETSGLMA-KKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLA 894
            :|::.:|.. .|||||||..|..:..|:.| ..|:|:|.|:.:|:||:||||:|..:||||||||
Zfish   633 LCMITEYME-NGDLNQFLSRHQLQEDGVQADSTSISYGTLINMASQISSGMKYLSSLNFVHRDLA 696

  Fly   895 TRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDV 959
            ||:|::|....:|:...|  ::|:.|..||.:::|     ...:|||||:|||:||||||..|||
Zfish   697 TRNCLVGMNNIIKIADFG--MSRNLYRGDYYRIQG-----RAVLPIRWMSWESILLGKFTMASDV 754

  Fly   960 WSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRD 1024
            |:|.|.||||||..:||||...:|:.||||.|..:||......|..|..||..:|.||..||:|:
Zfish   755 WAFGVTLWEILTLCKEQPYAQFTDEQVIENTGEFFRDQNKQVYLLRPACCPESLYSLMLNCWRRN 819

  Fly  1025 ESSRPSFREIHLYLQRKN 1042
            ...||:|.|||..|..::
Zfish   820 AKERPTFLEIHSTLTEQH 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	59/152 (39%)
		PTKc_DDR	753..1040	CDD:270644	133/300 (44%)
ddr2b	XP_017206819.2	FA58C	28..180	CDD:238014	59/153 (39%)
		PTKc_DDR	542..835	CDD:270644	133/300 (44%)