DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and ddr2a

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	XP_005166320.1	Gene:	ddr2a / 556380	ZFINID:	ZDB-GENE-090316-2	Length:	868	Species:	Danio rerio

Alignment Length:	996	Identity:	330/996 - (33%)
Similarity:	473/996 - (47%)	Gaps:	215/996 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVS-R 157
            |..:.:::..|.|:..|||..|.|.|..|:|||... .:...::.||..:...|||||:.... .
Zfish    26 SGAVQSQVNPGVCRSPLGMSRGQILDEDISASSQWS-ESTAAKYGRLDCEEGDGAWCPEIPAEPE 89

  Fly   158 GLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNI 222
            .:.|:||:||..:|.::.:.||||...|.|.|:.:.|.|:|.|.| .:||.||:.|||||:.||.
Zfish    90 NMKEFLQIDLRSLHFITLVGTQGRHAGGIGNEFAQTYKIKYSRDG-SRWISWRNRQGKEVIEGNR 153

  Fly   223 NTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKGMQ---RGMDID 284
            |.|..|...|:|.:.|..||..|...:...||:|.|:.||.|.:|:|||:.|.|.|   .|..|.
Zfish   154 NAYDIVLKDLEPPIIARFVRFMPVIDHSMNVCMRVELYGCEWLDGLVSYNSPLGQQMSLNGQHIY 218

  Fly   285 LSDKTYDG---YEEGDHYVNGLGQLVDGQRGKDNFR-ADINGLGKGYEWIGWRNDTLLGRPVEII 345
            |:|..|||   |.    ...|||||.||..|.|:|. :.:..:..||:::||.|::.....|||:
Zfish   219 LNDSVYDGAMSYS----MTEGLGQLTDGMCGLDDFTLSHVYNVWPGYDYVGWTNESFPNGYVEIM 279

  Fly   346 FEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIK 410
            |||:..||.:.:.:|.|||||:.|:.|.....:|. ....:...||.||.:.|.|...||.||:.
Zfish   280 FEFDRTRNFTTMKVHCNNMFSRRVKTFQKVVCYFR-SELDWEATPVSFSPVMDDVNPSARFVTVS 343

  Fly   411 LHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFTDELANGEKQSVTSEYPLQRDEVGRAISS 475
            |::.:...::...||:..|||.|||||                  ||.|:.|
Zfish   344 LYNHMASAIKCQYYFSDIWMMFSEITF------------------QSDTAMY------------- 377

  Fly   476 GGERSQHTTQVISPK---PIDHQ---EP----ETSFVGVIITVLGTIIMLLVAFILLIVARNKHV 530
                   .|.:..|:   |:.:|   :|    :.|...::|..|..||.:|||.|::|:.|....
Zfish   378 -------NTTLTPPRTDPPLTNQPGDDPTHKVDDSNTRILIGCLVAIIFILVAIIVIILWRQVWQ 435

  Fly   531 RSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDL 595
            :..|                     ||...|.|:|.:... |:..|.|..|...|.:|
Zfish   436 KMLE---------------------KVSRRMLDDELTASL-SIQSETFTYNNNNSPSS------- 471

  Fly   596 QRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTAS 660
                                 ||..|:                       ||..:
Zfish   472 ---------------------VPSEQE-----------------------SSSTY---------- 482

  Fly   661 ARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVA---PPGSQSSGSLSSSTTAATTPTSGV 722
                                 |:.:...|...:|..:.   |..||:|...:|:.||:.||:..
Zfish   483 ---------------------ERIFPLGPDYQEPSRLVRKLPEFSQTSEDTASTITASKTPSVN- 525

  Fly   723 VGVGKPHHYNLDMSANFADINEERA--------------NCQVQEFPRQSLVIVEKLGSGVFGEL 773
            |..|.||:...|: .|...:.....              :..|:||.|:.|...||||.|.|||:
Zfish   526 VQEGVPHYAEADI-VNLQGVTGGNTYAVPALTMDLLSGKDVAVEEFSRKLLTFKEKLGEGQFGEV 589

  Fly   774 HLCETNVL--------------NAT-LVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVG 823
            ||||...:              |.| ||||..||..||.:.|.:|..:.|.:::|.|||:.||:.
Zfish   590 HLCEAEGMQDFMDKDFSFDVTENQTVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLA 654

  Fly   824 ACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKS----LSFGCLVYIATQIASGMKHLE 884
            .|:..:|:|::.:|.. .|||||||..|  |..|::|..|    :|:..|.::|:|||||||:|.
Zfish   655 VCMSSDPLCMITEYME-NGDLNQFLSRH--EPEGMIALLSNAPTVSYSNLHHMASQIASGMKYLS 716

  Fly   885 QMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVL 949
            .:||||||||||:|::|....:|:...|  ::|:.|:.||.:::|     ...:|||||:|||:|
Zfish   717 SLNFVHRDLATRNCLVGKNFTIKIADFG--MSRNLYSGDYYRIQG-----RAVLPIRWMSWESIL 774

  Fly   950 LGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIY 1014
            ||||||.||||:|.|.|||:|||.:||||..|||:.||||.|..:||.:....||.||.||..:|
Zfish   775 LGKFTTSSDVWAFGVTLWEMLTFCKEQPYSQLSDEQVIENTGEFFRDQRRQIYLPQPPMCPDPVY 839

  Fly  1015 DLMCECWQRDESSRPSFREIH 1035
            .||..||.|:...||||:|||
Zfish   840 KLMLSCWHRNTKERPSFQEIH 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	60/156 (38%)
		FA58C	109..261	CDD:238014	59/152 (39%)
		PTKc_DDR	753..1040	CDD:270644	141/302 (47%)
		TyrKc	759..1038	CDD:197581	138/296 (47%)
ddr2a	XP_005166320.1	FA58C	38..193	CDD:214572	60/156 (38%)
		FA58C	40..192	CDD:238014	59/153 (39%)
		PKc_like	569..865	CDD:304357	141/302 (47%)
		STYKc	575..863	CDD:214568	138/296 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1794
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68505
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1210
OMA	1	1.010	-	-		QHG45751
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm6449
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4211
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.010