Protein Alignment Ddr and ddr2a

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: XP_005166320.1
• Gene: ddr2a / 556380
• ZFINID: ZDB-GENE-090316-2
• Length: 868
• Species: Danio rerio
• Alignment Length: 996
• Identity: 330/996 - (33%)
• Similarity: 473/996 - (47%)
• Gaps: 215/996 - (21%)

  Fly    94 SNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVS-R 157
            |..:.:::..|.|:..|||..|.|.|..|:|||... .:...::.||..:...|||||:.... .
Zfish    26 SGAVQSQVNPGVCRSPLGMSRGQILDEDISASSQWS-ESTAAKYGRLDCEEGDGAWCPEIPAEPE 89

  Fly   158 GLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNI 222
            .:.|:||:||..:|.::.:.||||...|.|.|:.:.|.|:|.|.| .:||.||:.|||||:.||.
Zfish    90 NMKEFLQIDLRSLHFITLVGTQGRHAGGIGNEFAQTYKIKYSRDG-SRWISWRNRQGKEVIEGNR 153

  Fly   223 NTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKGMQ---RGMDID 284
            |.|..|...|:|.:.|..||..|...:...||:|.|:.||.|.:|:|||:.|.|.|   .|..|.
Zfish   154 NAYDIVLKDLEPPIIARFVRFMPVIDHSMNVCMRVELYGCEWLDGLVSYNSPLGQQMSLNGQHIY 218

  Fly   285 LSDKTYDG---YEEGDHYVNGLGQLVDGQRGKDNFR-ADINGLGKGYEWIGWRNDTLLGRPVEII 345
            |:|..|||   |.    ...|||||.||..|.|:|. :.:..:..||:::||.|::.....|||:
Zfish   219 LNDSVYDGAMSYS----MTEGLGQLTDGMCGLDDFTLSHVYNVWPGYDYVGWTNESFPNGYVEIM 279

  Fly   346 FEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIK 410
            |||:..||.:.:.:|.|||||:.|:.|.....:|. ....:...||.||.:.|.|...||.||:.
Zfish   280 FEFDRTRNFTTMKVHCNNMFSRRVKTFQKVVCYFR-SELDWEATPVSFSPVMDDVNPSARFVTVS 343

  Fly   411 LHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFTDELANGEKQSVTSEYPLQRDEVGRAISS 475
            |::.:...::...||:..|||.|||||                  ||.|:.|
Zfish   344 LYNHMASAIKCQYYFSDIWMMFSEITF------------------QSDTAMY------------- 377

  Fly   476 GGERSQHTTQVISPK---PIDHQ---EP----ETSFVGVIITVLGTIIMLLVAFILLIVARNKHV 530
                   .|.:..|:   |:.:|   :|    :.|...::|..|..||.:|||.|::|:.|....
Zfish   378 -------NTTLTPPRTDPPLTNQPGDDPTHKVDDSNTRILIGCLVAIIFILVAIIVIILWRQVWQ 435

  Fly   531 RSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDL 595
            :..|                     ||...|.|:|.:... |:..|.|..|...|.:|
Zfish   436 KMLE---------------------KVSRRMLDDELTASL-SIQSETFTYNNNNSPSS------- 471

  Fly   596 QRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTAS 660
                                 ||..|:                       ||..:
Zfish   472 ---------------------VPSEQE-----------------------SSSTY---------- 482

  Fly   661 ARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVA---PPGSQSSGSLSSSTTAATTPTSGV 722
                                 |:.:...|...:|..:.   |..||:|...:|:.||:.||:..
Zfish   483 ---------------------ERIFPLGPDYQEPSRLVRKLPEFSQTSEDTASTITASKTPSVN- 525

  Fly   723 VGVGKPHHYNLDMSANFADINEERA--------------NCQVQEFPRQSLVIVEKLGSGVFGEL 773
            |..|.||:...|: .|...:.....              :..|:||.|:.|...||||.|.|||:
Zfish   526 VQEGVPHYAEADI-VNLQGVTGGNTYAVPALTMDLLSGKDVAVEEFSRKLLTFKEKLGEGQFGEV 589

  Fly   774 HLCETNVL--------------NAT-LVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVG 823
            ||||...:              |.| ||||..||..||.:.|.:|..:.|.:::|.|||:.||:.
Zfish   590 HLCEAEGMQDFMDKDFSFDVTENQTVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLA 654

  Fly   824 ACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKS----LSFGCLVYIATQIASGMKHLE 884
            .|:..:|:|::.:|.. .|||||||..|  |..|::|..|    :|:..|.::|:|||||||:|.
Zfish   655 VCMSSDPLCMITEYME-NGDLNQFLSRH--EPEGMIALLSNAPTVSYSNLHHMASQIASGMKYLS 716

  Fly   885 QMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVL 949
            .:||||||||||:|::|....:|:...|  ::|:.|:.||.:::|     ...:|||||:|||:|
Zfish   717 SLNFVHRDLATRNCLVGKNFTIKIADFG--MSRNLYSGDYYRIQG-----RAVLPIRWMSWESIL 774

  Fly   950 LGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIY 1014
            ||||||.||||:|.|.|||:|||.:||||..|||:.||||.|..:||.:....||.||.||..:|
Zfish   775 LGKFTTSSDVWAFGVTLWEMLTFCKEQPYSQLSDEQVIENTGEFFRDQRRQIYLPQPPMCPDPVY 839

  Fly  1015 DLMCECWQRDESSRPSFREIH 1035
            .||..||.|:...||||:|||
Zfish   840 KLMLSCWHRNTKERPSFQEIH 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	59/152 (39%)
		PTKc_DDR	753..1040	CDD:270644	141/302 (47%)
ddr2a	XP_005166320.1	FA58C	40..192	CDD:238014	59/153 (39%)
		Protein Kinases, catalytic domain	569..865	CDD:473864	141/302 (47%)