Protein Alignment Ddr and Alk

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Alignment Length: 1150
• Identity: 246/1150 - (21%)
• Similarity: 386/1150 - (33%)
• Gaps: 364/1150 - (31%)

  Fly    19 SPTIGVPALVESQGGEGHESRRPATNYLKSY---CRIKRHGVNNSK--TLCWLTLTLILLANRFG 78
            |||       ...|.:|..:.:...|....|   ..:.:| :|||:  ::.......|:::..|.
  Fly   531 SPT-------HDTGPDGDHTMQHLQNNTSGYYMLVNMNQH-MNNSEKNSIIGFASNAIMVSKTFN 587

  Fly    79 MGTAV-GTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDMGNVGPQHARLKI 142
            ...:| |.|::|                      ..:..:..|.|     |..|. .|....|.:
  Fly   588 PPPSVHGNPDSP----------------------YRNSCVVRFFI-----HQFGK-NPGSINLSV 624

  Fly   143 -----------------DNNGGAWCPKHMVSRGLTE--YLQVDL-LGVHLVSAIRTQG------R 181
                             .|.|..|.....|...:|.  |||.:. :|:.:.|.:....      .
  Fly   625 VEMKEKENITTTLWWSTKNQGSDWMRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPEC 689

  Fly   182 FGKGQGQEYTEAYVIEYW--RPGLKKWIRWRSLQGKEVLPGNINTYSEVE--NVLQPSVFASKVR 242
            ||....:::...|  .||  |..||.                 .||.:.|  |.|:.:...::..
  Fly   690 FGLNIPEDHLGGY--NYWDVRQNLKS-----------------PTYKDFEYTNYLELTTCDTRGM 735

  Fly   243 LYP--------YSQYDRTVCLRAEIVGCAWEEGIVSYSIPKGMQRGMDIDLSDKTYDGYEEGDHY 299
            :.|        |.:.::|..||...|       :...|..||||:          :....|| ||
  Fly   736 IGPSQAQCEAAYREQNKTHVLREVHV-------VEDQSSYKGMQK----------WKVPHEG-HY 782

  Fly   300 VNGLGQLVDGQRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNM 364
            .    .:..|..|         |||.|  .:|                  :.|...||.|
  Fly   783 T----IIAKGASG---------GLGSG--GVG------------------SSRGSVAVAI----- 809

  Fly   365 FSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLV-----LDHARDVTIKLHHRLGRYVQLHLY 424
                :::..:.:::|.:|.:   ||......|..|.     .||..|        |.:|     .
  Fly   810 ----LELHKNEELYFLVGQQ---GENACIKSMGVLKEAGCGTDHDLD--------LAQY-----S 854

  Fly   425 FAARWMMISEI--------------TFI-------SAPV----------VGNFTDE-LANGEKQS 457
            |.::..|:..|              .|:       :.|:          :|.:.|| ..:|:|..
  Fly   855 FRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAK 919

  Fly   458 VTSEYPLQRDEVGR----------AISSGGERSQHTTQVISPKPIDHQEPETSFVGVIITVLGTI 512
                 |||..|.|:          |...||.|::. .|.:||
  Fly   920 -----PLQAPESGQINGEPLNKKTAGPGGGWRAKE-DQALSP----------------------- 955

  Fly   513 IMLLVAFILLIVARNKH---VRSRENGLDAFQHNFSP--------DTLNGNGVL---KVVTTMDD 563
               .....||...|..|   |...:||....:|....        :|..|.|..   .|..|
  Fly   956 ---TYGAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVYLT--- 1014

  Fly   564 NESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAP 628
             ||:.:..|.|..|                       |....::.:|.....:.|....::|...
  Fly  1015 -ESNGEGGSSYISP-----------------------SRSLREISEIHAGASSGPGAIIIIPAIE 1055

  Fly   629 PCGSG----------------CGTGTGTGPGRGSSPEFVVATGKVTASARNS---LNAATLPLPS 674
            .||..                |..|........::.|.....||.:.....|   ::.|.|.:..
  Fly  1056 GCGCDYRCVALDEFRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICI 1120

  Fly   675 PPVPPPLEKYYAATPVSSKPMPVAPPG----SQSSGSLSSSTTAATTPTSGVVGVGKPHHYNLDM 735
            ..:...|...|.....|.|...:....    ::...::..|......|..|..|:...|
  Fly  1121 AALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGH------ 1179

  Fly   736 SANFADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVLNATL----VAVATLRPGAN 796
                .|:|      .:.:..|.||.:|..||.|.|||:::......:...    |||.|||....
  Fly  1180 ----IDVN------SLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPK 1234

  Fly   797 DHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQE--HVAETSGLM 859
            ....::|..:|..:|:.:.||:..|:|.|...:|..||.:.. ..|||.:||:|  :..|...|:
  Fly  1235 REKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELL-AGGDLQKFLRENRNTPERPSLL 1298

  Fly   860 AKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCII---GPELCVKVCSIGTVINRSAYA 921
            ..|.|.| |    |..:|.|.:::|...|:|||:|.|:|::   ||...||:...|  ::|..|.
  Fly  1299 TMKDLLF-C----ALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFG--MSRDIYR 1356

  Fly   922 SDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSV 986
            |||.:..|     ...:||:||..|:.|.|.||:|:|||||.:.|||:.:..| .||....:..|
  Fly  1357 SDYYRKGG-----KAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGR-SPYPGQHNTQV 1415

  Fly   987 IENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSF 1031
            :|   |:.|..:    |..|..||..||.:|.:||......||:|
  Fly  1416 ME---LVVRGGR----LGSPTECPVSIYKVMADCWNPTPEDRPTF 1453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	34/189 (18%)
		PTKc_DDR	753..1040	CDD:270644	97/287 (34%)
Alk	NP_652600.1	MAM	288..447	CDD:99706
		MAM	505..689	CDD:99706	33/193 (17%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	97/288 (34%)