DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and DDR2

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_001014796.1	Gene:	DDR2 / 4921	HGNCID:	2731	Length:	855	Species:	Homo sapiens

Alignment Length:	976	Identity:	322/976 - (32%)
Similarity:	458/976 - (46%)	Gaps:	185/976 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 AEMPIGTCKQALGMESGAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVS-RGLTEY 162
            |::....|:..|||..|.|.|..|||||... .:...::.||..:...|||||:..|. ..|.|:
Human    23 AQVNPAICRYPLGMSGGQIPDEDITASSQWS-ESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEF 86

  Fly   163 LQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSE 227
            ||:||..:|.::.:.||||...|.|.|:...|.|.|.|.| .:||.||:..||:||.||.|.|..
Human    87 LQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDG-TRWISWRNRHGKQVLDGNSNPYDI 150

  Fly   228 VENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKGMQ----RGMDIDLSDK 288
            ....|:|.:.|..||..|.:.:...||:|.|:.||.|.:|:|||:.|.|.|    .|..|.|:|.
Human   151 FLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDS 215

  Fly   289 TYDGYEEGDHYVNGLGQLVDGQRGKDNF-RADINGLGKGYEWIGWRNDTLLGRPVEIIFEFETVR 352
            .||| ..|.....|||||.||..|.|:| :.....:..||:::||||::.....:||:|||:.:|
Human   216 VYDG-AVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIR 279

  Fly   353 NLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGR 417
            |.:.:.:|.||||:|.|::|...:.:|......:....:.|..:.|.|...||.||:.||||:..
Human   280 NFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMAS 344

  Fly   418 YVQLHLYFAARWMMISEITFISAPVVGNFTDELANGEKQSVTSEYPLQRDEVGRAISSGGERSQH 482
            .::...:||..|||.|||||.|...:.|.::.|........|.:..|:.|:
Human   345 AIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDD-------------- 395

  Fly   483 TTQVISPKPIDHQEPETSFVGVIITVLGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPD 547
                             |...::|..|..||.:|:|.|::|:.|....:..|
Human   396 -----------------SNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLE------------- 430

  Fly   548 TLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIVC 612
                    |....|.|:|.::..:.    |.:::|:.:
Human   431 --------KASRRMLDDEMTVSLSL----PSDSSMFNN--------------------------- 456

  Fly   613 QDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTASARNSLNAATLPL-PSPP 676
                                          .|.|||         :....||......|| |...
Human   457 ------------------------------NRSSSP---------SEQGSNSTYDRIFPLRPDYQ 482

  Fly   677 VPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFAD 741
            .|..|          .:.:|...||.:.||  .|.......| ||..||  ||:...|: .|...
Human   483 EPSRL----------IRKLPEFAPGEEESG--CSGVVKPVQP-SGPEGV--PHYAEADI-VNLQG 531

  Fly   742 INEERA--------------NCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVL----------- 781
            :.....              :..|:||||:.|...||||.|.|||:||||...:
Human   532 VTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALD 596

  Fly   782 ----NATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLG 842
                ...||||..||..||.:.|.:|..:.|.:::|.|||:..|:..|:.|:|:|::.:|.. .|
Human   597 VSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYME-NG 660

  Fly   843 DLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVK 907
            ||||||..|....|.....:::|:..|.::|||||||||:|..:||||||||||:|::|....:|
Human   661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIK 725

  Fly   908 VCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTF 972
            :...|  ::|:.|:.||.:::|     ...:|||||:|||:|||||||.||||:|.|.|||..||
Human   726 IADFG--MSRNLYSGDYYRIQG-----RAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTF 783

  Fly   973 AREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLY 1037
            .:||||..|||:.||||.|..:||......||.|..||..:|.||..||:||..:||||:||||.
Human   784 CQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLL 848

  Fly  1038 L 1038
            |
Human   849 L 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	61/156 (39%)
		FA58C	109..261	CDD:238014	60/152 (39%)
		PTKc_DDR	753..1040	CDD:270644	139/301 (46%)
		TyrKc	759..1038	CDD:197581	134/293 (46%)
DDR2	NP_001014796.1	FA58C	32..184	CDD:238014	60/153 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..471		7/84 (8%)
		PTKc_DDR2	557..851	CDD:270677	139/301 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1838
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68505
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1223
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45751
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm8570
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4211
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	13.010