DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ddr and ROR2

DIOPT Version :10

Sequence 1:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster
Sequence 2:NP_004551.2 Gene:ROR2 / 4920 HGNCID:10257 Length:943 Species:Homo sapiens


Alignment Length:572 Identity:156/572 - (27%)
Similarity:244/572 - (42%) Gaps:143/572 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   524 VARNKHVRSRENGL----------DAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSL--YHE 576
            :.|.::..:|.|.|          :|.....|||..|   .:::         .|....|  ||:
Human   263 LCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAAN---CMRI---------GIPAERLGRYHQ 315

  Fly   577 PFNAN--MYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAV--PHMQQL-LPNAPPCGSGCGT 636
            .:|.:  .|...||                |......||.:|:  ||...| ..:.|..|.|...
Human   316 CYNGSGMDYRGTAS----------------TTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAY 364

  Fly   637 GTGTGPGRGSSPEFVVATGKV--------TASARNSLNAATLPLPSPPVPPPL------------ 681
            ....| |:...|........|        :.|.|:|.....|.:..|.:..||            
Human   365 CRNPG-GQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMC 428

  Fly   682 ---EKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADIN 743
               :|..|:||...:.|  |.|.......|                                 ||
Human   429 RNKQKASASTPQRRQLM--ASPSQDMEMPL---------------------------------IN 458

  Fly   744 EERANCQVQEFPRQSLVIVEKLGSGVFGEL---HLC------ETNVLNATLVAVATLRPGANDHL 799
            :.: ..:::|....::..:|:||...||::   ||.      :|..     ||:.||:..|...|
Human   459 QHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQA-----VAIKTLKDKAEGPL 517

  Fly   800 RKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCL-GDLNQFL-----QEHVAET-SG 857
            |:|||.:|...|:|..|||..|:|...:|:|:.::  :|:|. |||::||     ...|..| ..
Human   518 REEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMI--FSYCSHGDLHEFLVMRSPHSDVGSTDDD 580

  Fly   858 LMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYAS 922
            ...|.:|.....|::..|||:||::|...:.||:|||||:.::..:|.||:..:|  :.|..||:
Human   581 RTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLG--LFREVYAA 643

  Fly   923 DYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVI 987
            ||.:|.|     :..:||||||.|:::.|||:..||:||:.|.|||:.::.. |||...|::.|:
Human   644 DYYKLLG-----NSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGL-QPYCGYSNQDVV 702

  Fly   988 ENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQ 1039
            |.|       :..::||.|.:||..:|.||.|||....|.||.|::||..|:
Human   703 EMI-------RNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLR 747

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 108/303 (36%)
ROR2NP_004551.2 I-set 64..152 CDD:400151
Ig strand B 79..83 CDD:409353
Ig strand C 92..96 CDD:409353
Ig strand E 118..122 CDD:409353
Ig strand F 132..137 CDD:409353
Ig strand G 145..148 CDD:409353
CRD_TK_ROR2 170..309 CDD:143577 10/57 (18%)
KR 314..395 CDD:214527 19/97 (20%)
PTKc_Ror2 466..749 CDD:270673 108/304 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 850..931
Blue background indicates that the domain is not in the aligned region.

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