DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ddr and NTRK1

DIOPT Version :10

Sequence 1:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster
Sequence 2:NP_002520.2 Gene:NTRK1 / 4914 HGNCID:8031 Length:796 Species:Homo sapiens


Alignment Length:846 Identity:215/846 - (25%)
Similarity:338/846 - (39%) Gaps:209/846 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   289 TYDGYEEGDHYVNGLGQL----VDGQRGKDNFR-ADINGLGKGYEWIGWRNDTLLGRPVEIIF-- 346
            |.||..:..|::.|...|    ::.|:...:.. .|:.|||:      .||.|::...:..:.  
Human    51 TRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGE------LRNLTIVKSGLRFVAPD 109

  Fly   347 EFETVRNLSAVIIHTNNMFS---KDVQVFVHAKVFFSIGGRHFS--------------------- 387
            .|.....||.:.:..|.:.|   |.||.....::..|....|.|                     
Human   110 AFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQK 174

  Fly   388 -----------------GEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMI--- 432
                             |.|.....:|:..:|...||.::.... ||.::     .|.|::.   
Human   175 LQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVE-GRGLE-----QAGWILTELE 233

  Fly   433 SEITFISA---PVVG----NFTDELANGEKQSVTSEYPLQRDEVGRA-------ISSGGERSQHT 483
            ...|.:.:   |.:|    |.|.:|   .:::||.   ...::||||       :|.......||
Human   234 QSATVMKSGGLPSLGLTLANVTSDL---NRKNVTC---WAENDVGRAEVSVQVNVSFPASVQLHT 292

  Fly   484 TQVIS----PKPIDHQEPETS----FVGVIITVLGTIIMLLVAFILLIVARNKHVRSRENGLDAF 540
            ...:.    |..:|.| |..|    |.|   :||.....:...|  |..|.|:.||.     ...
Human   293 AVEMHHWCIPFSVDGQ-PAPSLRWLFNG---SVLNETSFIFTEF--LEPAANETVRH-----GCL 346

  Fly   541 QHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNAN-----------MYTSAASACPMND 594
            :.|......|||..|..........:|| ..:....||..|           :.|::.|..|   
Human   347 RLNQPTHVNNGNYTLLAANPFGQASASI-MAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDP--- 407

  Fly   595 LQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTA 659
            ::::..:|....|. :....:|...:..||.....||                            
Human   408 VEKKDETPFGVSVA-VGLAVFACLFLSTLLLVLNKCG---------------------------- 443

  Fly   660 SARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAP-PGSQSSGSLSSSTTAATTPTSGVV 723
             .||....                        ::|..:|| .|...|....:...::.:||.| .
Human   444 -RRNKFGI------------------------NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG-K 482

  Fly   724 GVGKPHHYNLDMSANFADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVL----NAT 784
            |.|...|. ::....|:|.      | |....|:.:|:..:||.|.||::.|.|.:.|    :..
Human   483 GSGLQGHI-IENPQYFSDA------C-VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKM 539

  Fly   785 LVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDY-SHCLGDLNQFL 848
            ||||..|:. |::..|::|:.:|:.|..|...::.|..|.|....|:.:|.:| .|  ||||:||
Human   540 LVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRH--GDLNRFL 601

  Fly   849 QEHVAETSGL-----MAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKV 908
            :.|..:...|     :|...|..|.|:.:|:|:|:||.:|..::|||||||||:|::|..|.||:
Human   602 RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 666

  Fly   909 CSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFA 973
            ...|  ::|..|::||.::.|.|     .:|||||..||:|..||||:||||||.|.||||.|:.
Human   667 GDFG--MSRDIYSTDYYRVGGRT-----MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG 724

  Fly   974 REQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYL 1038
            : ||:..||:...|:.|       .....|..|..||.|:|.:|..||||:...|.|.:::|..|
Human   725 K-QPWYQLSNTEAIDCI-------TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 781

  Fly  1039 Q 1039
            |
Human   782 Q 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 113/297 (38%)
NTRK1NP_002520.2 leucine-rich repeat 68..92 CDD:275378 5/23 (22%)
LRR 1 90..113 6/28 (21%)
LRR_8 92..150 CDD:404697 12/63 (19%)
leucine-rich repeat 93..116 CDD:275378 4/22 (18%)
LRR 2 116..137 6/20 (30%)
leucine-rich repeat 117..139 CDD:275378 7/21 (33%)
leucine-rich repeat 140..152 CDD:275378 1/11 (9%)
LRRCT_2 151..192 CDD:465313 2/40 (5%)
Ig_TrkABC_d4 195..282 CDD:409361 20/98 (20%)
Ig strand A 195..201 CDD:409361 0/5 (0%)
Ig strand B 210..219 CDD:409361 2/9 (22%)
Ig strand C 222..229 CDD:409361 2/11 (18%)
Ig strand C' 231..233 CDD:409361 0/1 (0%)
Ig strand D 236..243 CDD:409361 1/6 (17%)
Ig strand E 246..255 CDD:409361 2/8 (25%)
Ig strand F 262..269 CDD:409361 2/9 (22%)
Ig strand G 272..279 CDD:409361 3/6 (50%)
IgI_TrKABC_d5 285..379 CDD:409360 24/105 (23%)
Ig strand A 285..291 CDD:409360 0/5 (0%)
Ig strand A' 293..296 CDD:409360 0/2 (0%)
Ig strand B 299..307 CDD:409360 1/7 (14%)
Ig strand C 310..317 CDD:409360 1/6 (17%)
Ig strand C' 320..323 CDD:409360 1/2 (50%)
Ig strand D 328..334 CDD:409360 1/7 (14%)
Ig strand E 341..349 CDD:409360 2/12 (17%)
Ig strand F 357..365 CDD:409360 3/7 (43%)
Ig strand G 368..376 CDD:409360 2/8 (25%)
Interaction with SQSTM1. /evidence=ECO:0000250 469..490 5/21 (24%)
PTKc_TrkA 504..783 CDD:270674 113/297 (38%)
DXXLL. /evidence=ECO:0000269|PubMed:26446845 537..541 0/3 (0%)
DXXLL. /evidence=ECO:0000269|PubMed:26446845 607..611 0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

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