DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and drl

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	700	Identity:	161/700 - (23%)
Similarity:	263/700 - (37%)	Gaps:	168/700 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 DVTIKLHHRLGRY-VQLHLYFAARWMMISEITFISAPVVGNFTDELANGEKQSVTSEYPLQRDEV 469
            ::.:.||..|... |...||:.....:.......:.||..|.:|  .....||:. ::||.. .:
  Fly    23 NIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISD--VTFTWQSLV-DHPLPY-SI 83

  Fly   470 GRAISSGGERSQHTTQVISPKPIDH--------QEPETSFVGVIITVLGTIIMLLVAFILLIVAR 526
            ..|.|.        |:|: |:||.:        .||:|  .|:.:...||              |
  Fly    84 NIATSD--------TEVL-PRPILNISRIGDVPVEPQT--WGIALKCSGT--------------R 123

  Fly   527 NKHVRSRENG---LDAFQHNFSPDTLNGNGVL--KVVTTMDDNESSIDKNSLYHEPFNANMYTSA 586
            |..|....|.   ||...:|      |.|.:.  |.:...::.:|:       ||.::.:.....
  Fly   124 NAEVTVTINVEVILDRATNN------NTNLIFKRKKICLREEQDSA-------HEEYDDDDLDLL 175

  Fly   587 ASACPMNDLQRQHVSP-DYTDVPD--IVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSP 648
            .:|      ::.|... .|.|..|  :|...:..|..|:.:....|    .|.|...|..|...|
  Fly   176 QTA------RKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESP----VGRGNSGGSKRDFDP 230

  Fly   649 ---EFVV--ATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKP-------------- 694
               |.:|  |:|.||......|   .|.|.|..:   |..|.|..|....|
  Fly   231 MLRENLVPPASGLVTLIVGGIL---ALVLVSTLI---LIAYCAKGPSKRHPSNGVHLIKTSSFQR 289

  Fly   695 MPVAPPGSQSSGSLSSSTTAATTPTSGVVG------VGKPHHYNLDMSANFADINEERANCQVQE 753
            :|.....:.:|..:..||   .|||...:.      ..:|..:|..:..........|.:|.|||
  Fly   290 LPTISSTAHNSIYVCPST---ITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQE 351

  Fly   754 FPRQSLVIVEKLGSGVFGELHLCETNVLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNV 818
                          |.||.::....|  :...|.|.|:...|:.........::..|.:.|.|||
  Fly   352 --------------GNFGRIYRGTYN--DCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNV 400

  Fly   819 ARLVGACLRD--EPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMK 881
            ..::|..:.|  .|. ::...:..:.:|..|||:.       ...:|::....|.:.:|:|..|:
  Fly   401 LSVLGISIEDYATPF-VLYAATGSVRNLKSFLQDP-------SYARSVTTIQTVLMGSQLAMAME 457

  Fly   882 HLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWE 946
            ||.....:|:|:|.|:|:|..:|.||:..  :.::|..:..||..|     ...:..||:|::.|
  Fly   458 HLHNHGVIHKDIAARNCVIDDQLRVKLTD--SALSRDLFPGDYNSL-----GDGEYRPIKWLSLE 515

  Fly   947 SVLLGKFTTKSDVWSFAVALWEILT-----FAREQPYE---HLSDKSVIENIGLIYRDYKMHELL 1003
            ::....:...||||||.|.:||:.|     :|...|||   :|.|.         ||       |
  Fly   516 ALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDG---------YR-------L 564

  Fly  1004 PMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQRKNLGFKPQTHTHM 1053
            ..|.|||.|::.:|..||....:.||||.::.:.|.        :.||.:
  Fly   565 AQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLS--------EFHTQI 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572
		FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	77/296 (26%)
		TyrKc	759..1038	CDD:197581	75/288 (26%)
drl	NP_001260566.1	WIF	21..157	CDD:128745	37/168 (22%)
		PTK_Ryk	336..606	CDD:270639	83/324 (26%)
		Pkinase_Tyr	343..599	CDD:285015	80/302 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940