Protein Alignment Ddr and Ret

DIOPT Version :9

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 1179
• Identity: 249/1179 - (21%)
• Similarity: 402/1179 - (34%)
• Gaps: 351/1179 - (29%)

  Fly    60 SKTLCWLTLTLILLANRFGMGTAVGTPET------PAAVGSNGLLAEMPIGTCKQALGMESGAIA 118
            |.|:.::||..|:...:......|..|.|      |....|..:.:::|:... |.|.||...:|
  Fly     3 STTIVFVTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQF-QVLRMEDNRLA 66

  Fly   119 -DFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRF 182
             |:..:..          |:..|:|:::.|     .:..|  |:|...:.....||:|      |
  Fly    67 SDYLYSLE----------QNPLLRINSSSG-----EIYMR--TDYRSPNSSATFLVTA------F 108

  Fly   183 GKGQ-----------GQEYTEAYVIEYWRPGLKKWIRWRSLQ---------------GKEVLPGN 221
            .:.|           ..|.|...:.||... |:....|.|.|               .:.||.|.
  Fly   109 PRDQPDHELLNVSHLSLEVTPQPLEEYCSE-LEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGA 172

  Fly   222 INTYSEVENVLQPSV------------FASKV-RLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSI 273
            :|  |.....|.|.|            |..|. |||.....|..     |:.|...:.|.:...|
  Fly   173 LN--SRAAKYLCPHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHD-----ELNGLNAKAGQLQARI 230

  Fly   274 ----------PKGMQRGMDIDLSDKTYDG--YEEG----DHYVNGLGQLVDGQRGKDNFRADING 322
                      .:...|.:||.|.|:..:|  .:|.    |.|:.......|.:.||.....|
  Fly   231 TCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVD--- 292

  Fly   323 LGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVF-----------VHAK 376
                       .|||... ..:::         ||...::.:|..|...:           |..:
  Fly   293 -----------KDTLEAN-AHLVY---------AVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQ 336

  Fly   377 VFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAP 441
            :.||..|        .|...|..|...|||:||                      :|.:..:||.
  Fly   337 LRFSRNG--------VFRETPYCVSLEARDLTI----------------------VSRVDAMSAT 371

  Fly   442 --VVGNFTDELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEPETSFVGV 504
              |..:......:..:|.:....|| |....|...|.........:.:||..:|:.:.    |.|
  Fly   372 ANVCYHINLSKLHESEQELPQALPL-RARQHRIFESEEFNGDSAGRSLSPPTVDYDKD----VSV 431

  Fly   505 IITVLGTI-IMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKV----------- 557
            ..:..... ::...:|:.|:..|:......|:.|.||      ...:.:|::.|
  Fly   432 YRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAF------GITSTSGIVFVKNPQVLEEAPE 490

  Fly   558 ------VTTMDDNESS----IDKNSLYHEPFNAN---MYTSAASACPMNDLQRQHVS-------- 601
                  ||.:|....|    |:.:.::..|.|.:   ...|.:..|.....|.|.|.
  Fly   491 TIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGG 555

  Fly   602 ---------------------PDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGC-GTGTGTGPGR 644
                                 |:....||.||..     :::|.|.|  |...| ..|...||..
  Fly   556 GSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDP-----LEELNPMA--CPQDCTPAGRIVGPHS 613

  Fly   645 GSSPEFVVATGKVTASARNSLNAATLPLPSPP-----------------------VPP--PLE-- 682
            .:..:..:.:...|....::...:..||...|                       .||  ||:
  Fly   614 SNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDP 678

  Fly   683 -----------------KYYAAT-P-----------VSSKPMPVAPPGSQSSGSLSSSTTAATTP 718
                             .::..| |           ::.:.|.....|.|   |:::|:..| .|
  Fly   679 MLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQ---SMTTSSKQA-LP 739

  Fly   719 TSGVVGVGKPHHYNLDMSANFA------DINEERANCQVQEFPRQSLVIVEKLGSGVFGE-LHLC 776
            .||              ..:||      ....|..:.: .||||:.|.:...||.|.||: |...
  Fly   740 ESG--------------GGDFALMPLQSGFRFESGDAK-WEFPREKLQLDTVLGEGEFGQVLKGF 789

  Fly   777 ETNVL---NATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYS 838
            .|.:.   ..|.|||..|:.|:|........|:.:.|.::|.|||.:|:|||...|...::.:|:
  Fly   790 ATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYA 854

  Fly   839 HCLGDLNQFLQ-EHVAETSG---------LMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDL 893
            . .|.|..:|: ....|.:|         :..|..|:|      |.||..||.:|.::..|||||
  Fly   855 R-YGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTF------AWQICKGMAYLSELKLVHRDL 912

  Fly   894 ATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSD 958
            |.|:.::......|:...|  :.|..|..|     .:..|....:|::|||.||:....:|:|||
  Fly   913 AARNVLLADGKICKISDFG--LTRDVYEDD-----AYLKRSRDRVPVKWMAPESLADHVYTSKSD 970

  Fly   959 VWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQR 1023
            ||||.|..||::|.. ..||..::.:::   ..|:...|:|..    |.||...:|.::..||..
  Fly   971 VWSFGVLCWELITLG-ASPYPGIAPQNL---WSLLKTGYRMDR----PENCSEAVYSIVRTCWAD 1027

  Fly  1024 DESSRPSFR 1032
            :.:.||||:
  Fly  1028 EPNGRPSFK 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	41/195 (21%)
		FA58C	109..261	CDD:238014	40/191 (21%)
		PTKc_DDR	753..1040	CDD:270644	91/294 (31%)
		TyrKc	759..1038	CDD:197581	87/288 (30%)
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	87/289 (30%)
		TyrKc	771..1042	CDD:197581	87/288 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940