Protein Alignment Ddr and Eph

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Alignment Length: 1021
• Identity: 238/1021 - (23%)
• Similarity: 388/1021 - (38%)
• Gaps: 268/1021 - (26%)

  Fly   145 NGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEY----------- 198
            |...|.|  .:.||....|.::     :...||....| .|......|.:.:.:
  Fly   140 NNWLWSP--FIDRGSANRLYIE-----IQFTIRDCSLF-PGNALSCKETFSLLFYEFDAATREPP 196

  Fly   199 -WRPGLKKWIRWRSLQGKEVLPGNINTYSEVE-NVLQPSVFASKVRLYPYSQYDRTVCL-----R 256
             |:....:.|. |...|:    |..|..|:|: |....|:..:|..:| ::..|:..|:     :
  Fly   197 PWQTDSYRLIA-RIAAGE----GRFNQNSDVDINTEVKSIAVNKKGVY-FAFRDQGACISVLAVK 255

  Fly   257 AEIVGC-AWEEGIVSYS-IPKG-------MQRGMDIDLSDKTYDGYEEGDHYVNGLGQ---LVDG 309
            ...:.| |..|....:: .|.|       .|.|..:|.::.    ||...:...|.|:   |..|
  Fly   256 VYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEP----YETPTYLCKGDGKWTILTGG 316

  Fly   310 QRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEIIFEFETVR------NLSAVIIHTNNMFSKD 368
            .|.|           .||| ..:.|.|....|:......|..:      |.:|  ..|.:.|.|.
  Fly   317 CRCK-----------AGYE-PNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNA--SKTGSPFCKC 367

  Fly   369 VQVFV-HAKVFFSIGGRHFS--GEPVQFSYMPDLVLDH----------------ARDVTIKLHHR 414
            ...|. |..     .|||..  ..|...:.:..|.:|.                :.:...|::|
  Fly   368 ASGFYRHPN-----DGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYH- 426

  Fly   415 LGRYVQLHLYFAARWMMISEITF-----ISAP-VVGNFTDELANGEKQSVTSEYPLQRDEVG--- 470
                              |:|.:     |.:| ||.|.:.:..|..|.::|:..|:....|.
  Fly   427 ------------------SDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHA 473

  Fly   471 -RAISSGGERSQHTTQ---------VISPK-----PIDHQEPETSFVGVIITVLGTIIMLLVAFI 520
             .::|...|..:|:.:         |.|..     |:|..|.:|....::.|.  ..::|...|.
  Fly   474 INSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTT--ESVLLSTVFN 536

  Fly   521 LLIVA---------RNKHVRSRENGLDAFQHNFSP----DTLNGNGV------LKVVTTMDDNES 566
            |.|:|         .:|.|:| :..|:.::..:.|    |.:|.:.:      ..:|..:::.|.
  Fly   537 LRILAITNKDADLEWDKPVQS-DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEY 600

  Fly   567 SIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCG 631
            ........:..|.:  |::...|..:     |.|...|.|...|.....|:......|
  Fly   601 GFQVRCKTNNGFGS--YSNMIYAQTL-----QSVGSVYDDSVQIRFIAGAIVTGVLFL------- 651

  Fly   632 SGCGTGTGTGPGRGSSPEFVVATGKVTASA------RNSLNAATLPLPSPPVPPPLEKYYAATPV 690
                            ..|::||.....|.      :.|.|...|||.           ||:..|
  Fly   652 ----------------VIFIIATVYFMRSKHQDDLDKKSTNHLPLPLD-----------YASNEV 689

  Fly   691 SSKPMPVAPPGSQSSGSLSSSTTAATTPTSG-VVGVGKPHHYNLDMSANFADINEERANCQVQEF 754
            :|  |...|       .:.......|||..| ......||.|             |..|..::||
  Fly   690 NS--MDTTP-------IVKKLHLNVTTPLFGNSRSYVDPHTY-------------EDPNQAIREF 732

  Fly   755 PRQ---SLVIVEK-LGSGVFGELHLCE------TNVLNATLVAVATLRPGANDHLRKEFRSKAKQ 809
            .|:   :.:.:|. :|.|.||:  :|.      .|.:....||:.||:||:::..|.:|.::|..
  Fly   733 AREIDANYITIEAIIGGGEFGD--VCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASI 795

  Fly   810 LAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIAT 874
            :.|...|||..|.|...|..|:.|:.:|.. .|.|:.||:.:..:...|.         |:.:..
  Fly   796 MGQFDHPNVIYLQGVVTRSNPVMIITEYME-NGSLDTFLRVNDGKFQTLQ---------LIVMLR 850

  Fly   875 QIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRS-AYASDYCQLEGFTGRQSQPM 938
            .|||||.:|..||:||||||.|:.::..:|..|:...|  ::|. ..|||     .:|.|..: :
  Fly   851 GIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFG--LSREIENASD-----AYTTRGGK-I 907

  Fly   939 PIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELL 1003
            |:||.|.|::...|||:.|||||:.|.|||::::. |:||.:.|::.||::|...||       |
  Fly   908 PVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYG-ERPYWNWSNQDVIKSIEKGYR-------L 964

  Fly  1004 PMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQRKNLGFKPQT 1049
            |.|.:||..:|.||.:|||:..:.||:|..|...|.  ||..:||:
  Fly   965 PAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLD--NLARQPQS 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	25/133 (19%)
		PTKc_DDR	753..1040	CDD:270644	101/297 (34%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	25/133 (19%)
		FN3	387..476	CDD:238020	17/107 (16%)
		FN3	536..623	CDD:238020	15/89 (17%)
		EphA2_TM	640..738	CDD:464211	29/153 (19%)
		PTKc_EphR	736..1002	CDD:270629	98/295 (33%)
		SAM_1	1029..1092	CDD:425739