Protein Alignment Ddr and InR

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Alignment Length: 1279
• Identity: 264/1279 - (20%)
• Similarity: 416/1279 - (32%)
• Gaps: 450/1279 - (35%)

  Fly     8 ESNSIYSRSECSPTIGVPALVESQGGEGHESRRPATNYLKSYCRIKRHGVNNSKTLCWLTLTLIL 72
            |:||:||        |:|.       .|.......|.|.||          .:|.:|
  Fly   604 ETNSVYS--------GIPY-------NGQCITHCPTGYQKS----------ENKRMC-------- 635

  Fly    73 LANRFGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDMGNV-GPQ 136
                                      ...|.|.|.:..   |..:.|....|...|....: |.:
  Fly   636 --------------------------EPCPGGKCDKEC---SSGLIDSLERAREFHGCTIITGTE 671

  Fly   137 HARLKIDNNGGAWCPKHMVSR---GL--TEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTE---- 192
            ...:.|....||    |::..   ||  ...:|..|: |||...:::...|     |..||
  Fly   672 PLTISIKRESGA----HVMDELKYGLAAVHKIQSSLM-VHLTYGLKSLKFF-----QSLTEISGD 726

  Fly   193 ---------AYVI------EYWRPGLKKWIRWRSLQG---------------KEVLP-------- 219
                     .||:      |.|.|....:||    :|               .::||
  Fly   727 PPMDADKYALYVLDNRDLDELWGPNQTVFIR----KGGVFFHFNPKLCVSTINQLLPMLASKPKF 787

  Fly   220 -----------GNINTY-SEVENVLQPSVFASKVRL---------YPYSQYDRTVCL---RAEIV 260
                       ||..:. :.|.||...||.|:...|         .|....:.|:..   ||.|
  Fly   788 FEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFI- 851

  Fly   261 GCAWEEGIVSYSI--PKGMQRGMDIDLSDKTYD----------------GYEEGDHYVNGL---G 304
                  |.|.|.:  |.|.......|..|..:.                .|....:||..:   .
  Fly   852 ------GFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISS 910

  Fly   305 QLVDGQRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVII---HTNNMFS 366
            :|.:.:....|||                  |..|||.::.....|..:.|.:.:   :.:..:.
  Fly   911 ELTNAESDVKNFR------------------TNPGRPSKVTEVVATAISDSKINVTWSYLDKPYG 957

  Fly   367 KDVQVFVHAKVF---FSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAAR 428
            ...:.|:.||:.   .....|.:..||:..:...||   .|...|.|
  Fly   958 VLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDL---PATTPTKK------------------ 1001

  Fly   429 WMMISEITFISAPVVGNFTDELANGEKQSVTSEYPLQRDEVGRAI-------------------- 473
                     ||.|:.|:.  :...|.|::.:.||..::.:.|...
  Fly  1002 ---------ISDPLAGDC--KCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGS 1055

  Fly   474 ---SSGGERSQHTTQVI----SPKPIDHQ-----EPETSFVGVIITVLGTIIMLLVAFILLIVAR 526
               |.|.|.:...:..|    :..|...:     |||      :..|.|::::
  Fly  1056 SDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPE------LDDVEGSVLL------------ 1102

  Fly   527 NKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANM--------- 582
             :||||..:..|||   |..|..|         |..| |..:..|..::|.|...:
  Fly  1103 -RHVRSITDDTDAF---FEKDDEN---------TYKD-EEDLSSNKQFYEVFAKELPPNQTHFVF 1153

  Fly   583 --------YTSAASACPMNDLQRQHVSPDY---TDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGT 636
                    |.....||      |:.:..:.   |.....:|.||.......
  Fly  1154 EKLRHFTRYAIFVVAC------REEIPSEKLRDTSFKKSLCSDYDTVFQTT-------------- 1198

  Fly   637 GTGTGPGRGSSPEF--VVATGKVTASARNSLNAATLPLPSPPVPPPLE--------KYYAATPVS 691
                     ...:|  :|...||.....|:..:......:|||.|..|        |......|.
  Fly  1199 ---------KRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVE 1254

  Fly   692 SKPMPVAPPGSQSSG---SLSSSTTAATTPTSGVVGVG---KPHHYNLDMSANFADI-------- 742
            .|....|...:|::|   .|:....:.....:.:.|.|   :..|..::...::|.:
  Fly  1255 EKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIG 1319

  Fly   743 ----------------------NEERANCQVQEF-------P------RQSLVIVEKLGSGVFGE 772
                                  |:...|.:|..|       |      |::::.:..||.|.||.
  Fly  1320 LAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGM 1384

  Fly   773 LHLCETNVLNA-------TLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEP 830
            ::   ..:|.:       ...|:.|:...|.|..|..|.|:|..:.:....:|.||:|.|.|.:|
  Fly  1385 VY---EGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQP 1446

  Fly   831 ICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSL------------SFGCLVYIATQIASGMKHL 883
            ..:|.:... .|||..:|:.|..|.........|            ::|.:..:|.:||.||.:|
  Fly  1447 ALVVMELMK-KGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYL 1510

  Fly   884 EQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESV 948
            ....|||||||.|:|::..:|.||:...|  :.|..|.:||.: :|..|.    :|:|||..||:
  Fly  1511 AAKKFVHRDLAARNCMVADDLTVKIGDFG--MTRDIYETDYYR-KGTKGL----LPVRWMPPESL 1568

  Fly   949 LLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENI---GLIYRDYKMHELLPMPPNCP 1010
            ..|.:::.|||:||.|.|||:.|.| .|||:.||::.|:..:   |::.|          |.|||
  Fly  1569 RDGVYSSASDVFSFGVVLWEMATLA-AQPYQGLSNEQVLRYVIDGGVMER----------PENCP 1622

  Fly  1011 REIYDLMCECWQRDESSRPSFREIHLYL--QRKNLGFKPQTHTH 1052
            ..::.||..||....|:||||.:|..||  |..|..||..:..|
  Fly  1623 DFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYH 1666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	44/223 (20%)
		PTKc_DDR	753..1040	CDD:270644	100/323 (31%)
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614	17/99 (17%)
		Recep_L_domain	663..781	CDD:460032	26/131 (20%)
		FN3	791..>964	CDD:442628	34/197 (17%)
		FN3	1224..1302	CDD:238020	15/77 (19%)
		PTKc_InsR_like	1364..1652	CDD:173625	98/309 (32%)