DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ddr and MET

DIOPT Version :10

Sequence 1:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster
Sequence 2:XP_011514525.1 Gene:MET / 4233 HGNCID:7029 Length:1409 Species:Homo sapiens


Alignment Length:762 Identity:172/762 - (22%)
Similarity:277/762 - (36%) Gaps:235/762 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 INGLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNN----------MFSKDVQVFVH 374
            |.|:||        |...:..|..:|...|..||.:....|.:|          :...::|:.:.
Human   779 ITGVGK--------NLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLK 835

  Fly   375 AKVFFSIGG---RHFS------------GEPVQFSYMPDLVLD-HARDV--------TIKLHHRL 415
            .|.||.:.|   ::|.            .:||..|...:.||: ...|:        .:|:.::.
Human   836 TKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKS 900

  Fly   416 GRYVQLHLYFAARWMMISEITFISAP-VVGNFTDELANGEKQSVTSEYPLQRDEVGRAISSGGER 479
            ...:.||          ||....:.| .:.....||....||:::|..      :|:.|      
Human   901 CENIHLH----------SEAVLCTVPNDLLKLNSELNIEWKQAISSTV------LGKVI------ 943

  Fly   480 SQHTTQVISPKPIDHQEPETSFVGVI--ITVLGTIIMLLVAFILLIVARNKHVRSRENGL---DA 539
                           .:|:.:|.|:|  :..:.|.::||:.|.|.:..| |.::...:.|   ||
Human   944 ---------------VQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKR-KQIKDLGSELVRYDA 992

  Fly   540 FQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASAC-----PMNDLQRQH 599
            ..|....|.|.....:...|.|..|| |:|..:.:.|....|  :|...:|     |:.|:....
Human   993 RVHTPHLDRLVSARSVSPTTEMVSNE-SVDYRATFPEDQFPN--SSQNGSCRQVQYPLTDMSPIL 1054

  Fly   600 VSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTASARNS 664
            .|.| :|:...:.|:.....:..|                       :||.|.|...|...    
Human  1055 TSGD-SDISSPLLQNTVHIDLSAL-----------------------NPELVQAVQHVVIG---- 1091

  Fly   665 LNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPH 729
                         |..|..::                                  :.|:|.|   
Human  1092 -------------PSSLIVHF----------------------------------NEVIGRG--- 1106

  Fly   730 HYNLDMSANFADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVLNATLVAVATLRPG 794
            |:.........|.:.::.:|.|:...|.:.:          ||:                     
Human  1107 HFGCVYHGTLLDNDGKKIHCAVKSLNRITDI----------GEV--------------------- 1140

  Fly   795 ANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDE--PICIVQDYSHCLGDLNQFLQEHVAETSG 857
                  .:|.::...:...|.|||..|:|.|||.|  |:.::....|  |||..|::.   ||..
Human  1141 ------SQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH--GDLRNFIRN---ETHN 1194

  Fly   858 LMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYAS 922
            ...|..:.||      .|:|.|||:|....|||||||.|:|::..:..|||...|  :.|..|..
Human  1195 PTVKDLIGFG------LQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFG--LARDMYDK 1251

  Fly   923 DYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVI 987
            :|..:...||.:   :|::|||.||:...|||||||||||.|.|||::| ....||..::...: 
Human  1252 EYYSVHNKTGAK---LPVKWMALESLQTQKFTTKSDVWSFGVLLWELMT-RGAPPYPDVNTFDI- 1311

  Fly   988 ENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
                .:|  ......|..|..||..:|::|.:||......||||.|:
Human  1312 ----TVY--LLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSEL 1352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 87/284 (31%)
METXP_011514525.1 Sema_MET 44..535 CDD:200539
PSI 538..580 CDD:214655
IPT_plexin_repeat1 582..675 CDD:238585
IPT_plexin_repeat2 676..759 CDD:238584
IPT_plexin_repeat3 761..856 CDD:238586 18/84 (21%)
IPT 857..953 CDD:214657 21/132 (16%)
PTKc_Met_Ron 1101..1362 CDD:270649 94/316 (30%)
Blue background indicates that the domain is not in the aligned region.

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