DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ddr and htl

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	109/396 - (27%)
Similarity:	171/396 - (43%)	Gaps:	94/396 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   701 GSQSSGSLSSSTTAATTPTSGVVGVGKP--------------HHYNLDMSANFADINEERANCQV 751
            |..||||:.       |....||.:.|.              :.|...:.:|:
  Fly   364 GGDSSGSMD-------TMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNW------------ 409

  Fly   752 QEFPRQSLVIVEKLGSGVFGELHLCETNVLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLS-- 814
             |.||..||:...||.|.||.:.:.|.|  || :|||..::.|   |...:..|..:::..:.
  Fly   410 -ELPRSHLVLGATLGEGAFGRVVMAEVN--NA-IVAVKMVKEG---HTDDDIASLVREMEVMKII 467

  Fly   815 --DPNVARLVGACLRDEPICIVQDYS-HCLGDLNQFL---------------QEHVAETSGLMAK 861
              ..|:..|:|.|.::.|:.::.:|: |  |:|..||               |...:..:.::.:
  Fly   468 GRHINIINLLGCCSQNGPLYVIVEYAPH--GNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITE 530

  Fly   862 KSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQ 926
            |.     |:..|.|||.||.:|.....:|||||.|:.::..:..:|:...|  :.|...::||.:
  Fly   531 KD-----LIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFG--LARDIQSTDYYR 588

  Fly   927 LEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIG 991
             :...||    :||:|||.||:....:.:||||||:.:.||||:|:. :|||      ..|.:..
  Fly   589 -KNTNGR----LPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYG-QQPY------PTIMSAE 641

  Fly   992 LIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLY----LQRK---------NL 1043
            .:|......:.:..|..|...||.||.:||..:...||.|.||..|    ||.|         ||
  Fly   642 ELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANL 706

  Fly  1044 GFKPQT 1049
            ...|.|
  Fly   707 DTPPST 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572
		FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	92/310 (30%)
		TyrKc	759..1038	CDD:197581	88/302 (29%)
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	92/327 (28%)
		STYKc	416..688	CDD:214568	87/298 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940