DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ddr and INSRR

DIOPT Version :10

Sequence 1:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster
Sequence 2:NP_055030.1 Gene:INSRR / 3645 HGNCID:6093 Length:1297 Species:Homo sapiens


Alignment Length:1228 Identity:270/1228 - (21%)
Similarity:428/1228 - (34%) Gaps:376/1228 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 VNNSKTLCWL-TLTLILLANRFGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADF 120
            |..::.||.| |:...||....|....||..           |.|.....|...||......|. 
Human   141 VEKNQELCHLSTIDWGLLQPAPGANHIVGNK-----------LGEECADVCPGVLGAAGEPCAK- 193

  Fly   121 QITASSAHDMGNVGPQHARLKIDNNGGAW----------CPKHMVSRGLTEYLQVDLLGVHLVSA 175
              |..|.|               .:...|          ||..|......|....:.||      
Human   194 --TTFSGH---------------TDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLG------ 235

  Fly   176 IRTQGRFGKGQGQE----------YTEAYVIEYWRPGLKKWIRWRSLQGKEV-----LPGNINTY 225
                   |..|.::          |.:...:....||..::..||.:..:..     :||..:|:
Human   236 -------GCSQPEDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTF 293

  Fly   226 SEVENVL-----------QPSVFASKVR-LYPY-----SQYDRTVCLRAEIVGCAWEEGIVSYSI 273
            ...:...           ..|:|..|.. |.|.     ::...::....::|||...||.:..::
Human   294 GIHQGSCLAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNL 358

  Fly   274 PKGMQRGMDIDLSDKTYDGYEEGDHYVNGLGQLVDG-QRGKDNFRADINGLGKGYEWIGWRNDTL 337
            .:|             |:...:..|.: ||.:.:.| .:.|.:|.....|..|..:.|  |.|.:
Human   359 RQG-------------YNLEPQLQHSL-GLVETITGFLKIKHSFALVSLGFFKNLKLI--RGDAM 407

  Fly   338 LGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLD 402
            :.            .|.:..::...|:  :.:..:|.|.:...:|       .:.|::.|.|.|:
Human   408 VD------------GNYTLYVLDNQNL--QQLGSWVAAGLTIPVG-------KIYFAFNPRLCLE 451

  Fly   403 HARDVTIKLHHRL-------GRYVQLH----------------LYFAA----------RWM---- 430
            |.        :||       ||..:..                |.|.:          ||.    
Human   452 HI--------YRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTEADRILLRWERYEP 508

  Fly   431 -----MISEITFISAPVVGNFTDEL---ANGEK--QSVTSEYPLQR-DEVGRAISSGGERSQH-- 482
                 ::|.|.:.......|.|:.:   |.|.:  ..:..|.||.| .|.|..::|....:|:  
Human   509 LEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLASLKPWTQYAV 573

  Fly   483 -------TTQVISPKPIDHQEPETSFVGV------------IITVLGTIIMLLVAFILLIVARNK 528
                   ||:..||    ||..::..|.:            :|:...:...|||.: .....||.
Human   574 FVRAITLTTEEDSP----HQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRW-KPPTQRNG 633

  Fly   529 HV--------RSRENG---LDAFQH--------NFSP--DTLNGNGVL---------------KV 557
            ::        |..|:|   |:.:.|        |..|  |..:|:...               :|
Human   634 NLTYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQV 698

  Fly   558 VTTMDDNESSIDKNSLYHEPFNANMYT--------SAASACPMNDLQRQH----------VSPDY 604
            :..::..|:|..|.   .|.|..|..|        ::.:..|..|..|..          .|.|:
Human   699 LPPLEAQEASFQKK---FENFLHNAITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDF 760

  Fly   605 TDVPDIVCQDYAV----PHMQQLLPNAPPCGS-----GCGTGT----GTGPGRGSSPEFVVATGK 656
            ....|.|.::.||    .|..:...:...|..     ||...|    .|.|.|    |.....||
Human   761 EIQEDKVPRERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHR----EADGIPGK 821

  Fly   657 VT--ASARNSLNAATLPLPSPPVPPPLEKYY---------AATPVSSKPMPVA----------PP 700
            |.  ||::||:....|   .||.|..|...|         .||.:....:..|          ||
Human   822 VAWEASSKNSVLLRWL---EPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPP 883

  Fly   701 GSQSSGSLSSSTTAATTPTSGV-----------------------VGV-------------GKPH 729
            |:.|:...::|.....:.|..|                       ||:             ||..
Human   884 GNYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKR 948

  Fly   730 HYNLDMSANFADINEERANCQVQ------EFPRQSLVIVEKLGSGVFGELHLCETNVLNA----T 784
            :..|     :|.:|.|..:....      |.||:.:.|:.:||.|.||.::......|.|    |
Human   949 NRTL-----YASVNPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEEST 1008

  Fly   785 LVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQ 849
            .||:.|:...|:.....||..:|..:......:|.||:|...:.:|..::.:.. ..|||...|:
Human  1009 PVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELM-TRGDLKSHLR 1072

  Fly   850 EHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTV 914
            ....|..........:.|.::.:|.:||.||.:|....|||||||.|:|::..:..||:...|  
Human  1073 SLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFG-- 1135

  Fly   915 INRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYE 979
            :.|..|.:||.: :|..|.    :|:||||.||:..|.|||.||||||.|.||||:|.| ||||:
Human  1136 MTRDVYETDYYR-KGGKGL----LPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLA-EQPYQ 1194

  Fly   980 HLSDKSVIENI---GLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
            .||::.|::.:   |:      :.||    ..||.::.:||..|||.:...||||..|
Human  1195 GLSNEQVLKFVMDGGV------LEEL----EGCPLQLQELMSRCWQPNPRLRPSFTHI 1242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdrNP_001014474.3 FA58C 109..261 CDD:238014 28/193 (15%)
PTKc_DDR 753..1040 CDD:270644 100/289 (35%)
INSRRNP_055030.1 Recep_L_domain 47..158 CDD:460032 5/16 (31%)
Furin-like 173..326 CDD:395614 29/183 (16%)
Recep_L_domain 346..461 CDD:460032 29/159 (18%)
FN3 <489..>640 CDD:442628 30/155 (19%)
FN3 605..>649 CDD:238020 8/44 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..687 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..758 3/25 (12%)
FN3 819..908 CDD:238020 23/91 (25%)
PTKc_InsR_like 972..1248 CDD:173625 100/290 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1267..1297
Blue background indicates that the domain is not in the aligned region.

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