DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and sev

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster

Alignment Length:	1041	Identity:	230/1041 - (22%)
Similarity:	378/1041 - (36%)	Gaps:	276/1041 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 GNVGPQHARLKIDNNGGAWCPKHMVSRGLTE----YLQVDLLGVHLVSAIRTQGRFGKGQGQEYT 191
            |::.|....|.:.:|.|..| .:.|:|.|..    ..|::|||...::     |:..:..|..|
  Fly  1578 GSLEPGSETLNLVDNQGKLC-VYDVARQLCTASALRAQLNLLGEDSIA-----GQLAQDSGYLY- 1635

  Fly   192 EAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSV--FASKVRL---YPYSQYDR 251
                      .:|.|              :|..|......|:.:|  ...:|||   :.|..|..
  Fly  1636 ----------AVKNW--------------SIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPP 1676

  Fly   252 TVCLRAEIVG-------------CAWEEGIVSYS------IPKGMQRGMDIDLSDKTYDGYEEGD 297
            ..||.....|             |.....:::.|      || |::..:::.|:.:  .|.||.|
  Fly  1677 KNCLLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPIP-GVRYQLNLTLAKE--PGSEEHD 1738

  Fly   298 HYVNGLGQLVDGQRGKDNF-------RADINGLGKGYEWIGWRNDTLLGRPVEIIFEFET---VR 352
            |.:..|||.:.|.....|.       |..::|:...:........||:..|:|::....|   .|
  Fly  1739 HGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPR 1803

  Fly   353 NLSAVIIH----------TNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLD----- 402
            |.|..::.          ...:.|:.|...:|.:       :...||.||         |
  Fly  1804 NFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQ-------QELDGENVQ---------DRREWE 1852

  Fly   403 -HARDVTIKLHHRL---------GRYVQLH-----------LYFAARWMMISEITFISAPVVGNF 446
             |.|.:.....|||         ..:||.|           |:..:    .:|:..:....:|.:
  Fly  1853 AHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRS----FAELPELQLLELGPY 1913

  Fly   447 T---------DELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEPETSFV 502
            :         |.|.:.:.:..:|...|:|:..|          .||..|:.|     .:|.|.:.
  Fly  1914 SLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAG----------NHTKMVVEP-----LQPRTRYQ 1963

  Fly   503 GVIITVLGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESS 567
                      ..||:.:..                       :|.....:|..:|..|:.|..|.
  Fly  1964 ----------CRLLLGYAA-----------------------TPGAPLYHGTAEVYETLGDAPSQ 1995

  Fly   568 IDKNSLYH---EPFNANMYTSAASACPM-----------NDLQRQH-----------------VS 601
            ..|..|.|   |.|......:..:..|:           :|::|:.                 ..
  Fly  1996 PGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEE 2060

  Fly   602 P--------DYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVT 658
            |        |:.:..::.|...:: |..:||.......|   ...|.||....|..  ||...|:
  Fly  2061 PVVVEDQWLDFCNTTELSCIVKSL-HSSRLLLFRVRARS---LEHGWGPYSEESER--VAEPFVS 2119

  Fly   659 ASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVV 723
            ...|.||..|.: .|:..|...:........|..:.:.......||..|:.|:.:...|... ::
  Fly  2120 PEKRGSLVLAII-APAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQ-LM 2182

  Fly   724 GVGKPHHYNLDMSANFADINEERANCQVQEFPR---QSLVIVEKLGSGVFGELH---LCETNVLN 782
            .|     .|...|...:|       ..:...|:   ..|.::..||||.|||::   |...:...
  Fly  2183 AV-----RNRAFSTTLSD-------ADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEE 2235

  Fly   783 ATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQF 847
            ...||:.:||.||::.  .|...:|:.::.....|:..|||.|...|.|.::.::... |||..:
  Fly  2236 PQRVAIKSLRKGASEF--AELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEA-GDLLSY 2297

  Fly   848 LQ-EHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPEL------- 904
            |: .....|........||...|:.:...:|:|..:||.|:|||||||.|:|::....
  Fly  2298 LRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRR 2362

  Fly   905 CVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEI 969
            .||:...|  :.|..|.|||.:.||     ...:|:|||:.||::.|.|||:||||:|.|..|||
  Fly  2363 TVKIGDFG--LARDIYKSDYYRKEG-----EGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEI 2420

  Fly   970 LTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
            ||.. :|||...::..|:.::       |....|..||.|..::|.|:..||:.|...|||||..
  Fly  2421 LTLG-QQPYAARNNFEVLAHV-------KEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRC 2477

  Fly  1035 H 1035
            :
  Fly  2478 Y 2478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	30/152 (20%)
		FA58C	109..261	CDD:238014	29/138 (21%)
		PTKc_DDR	753..1040	CDD:270644	97/297 (33%)
		TyrKc	759..1038	CDD:197581	96/288 (33%)
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	20/113 (18%)
		FN3	1993..2111	CDD:238020	19/121 (16%)
		Pkinase_Tyr	2209..2481	CDD:285015	96/288 (33%)
		PTKc_c-ros	2213..2483	CDD:270640	95/284 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940