Protein Alignment Ddr and Alk

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_001162572.1
• Gene: Alk / 266802
• RGDID: 628622
• Length: 1617
• Species: Rattus norvegicus
• Alignment Length: 469
• Identity: 116/469 - (24%)
• Similarity: 194/469 - (41%)
• Gaps: 85/469 - (18%)

  Fly   631 GSGCGTGTGTG---PGRGSS-----------------------PEFVVATGKVTASARNSLNAAT 669
            |.||.:|.|.|   .|..:|                       |...|..|....:.::.||.:.
  Rat   929 GGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSH 993

  Fly   670 LPLPSPPVPPPLEKYY-------------AATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSG 721
            ..:....:.|...|..             .:..||..|.|..|.....|...|:...|.....||
  Rat   994 CEVDECHMDPESHKVICFCDHGTVLADDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSG 1058

  Fly   722 VVGVGKPHHYNL------------------------DMSANFADINEERANCQVQEFPRQSLVIV 762
            ::.|.:..|..|                        |.:.|:....:..:...::|.||:::.::
  Rat  1059 IMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLI 1123

  Fly   763 EKLGSGVFGELHLCET----NVLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVG 823
            ..||.|.|||::..:.    |..:...|||.||....::....:|..:|..:::.:..|:.|.:|
  Rat  1124 RGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIG 1188

  Fly   824 ACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNF 888
            ..|:..|..|:.:.. ..|||..||:|.....:   ...||:...|:::|..||.|.::||:.:|
  Rat  1189 VSLQALPRFILLELM-AGGDLKSFLRETRPRPN---QPTSLAMLDLLHVARDIACGCQYLEENHF 1249

  Fly   889 VHRDLATRSCIIGPELCVKVCSIGTV-INRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGK 952
            :|||:|.|:|::......::..||.. :.|..|.:.|.:..|     ...:|::||..|:.:.|.
  Rat  1250 IHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGG-----CAMLPVKWMPPEAFMEGI 1309

  Fly   953 FTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLM 1017
            ||:|:|.|||.|.||||.:.. ..||...|::.|:|.:....|       :..|.|||..:|.:|
  Rat  1310 FTSKTDTWSFGVLLWEIFSLG-YMPYPSKSNQEVLEFVTSGGR-------MDPPKNCPGPVYRIM 1366

  Fly  1018 CECWQRDESSRPSF 1031
            .:|||.....||:|
  Rat  1367 TQCWQHQPEDRPNF 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	86/284 (30%)
Alk	NP_001162572.1	MAM	270..428	CDD:99706
		MAM	484..639	CDD:459878
		FXa_inhibition	991..1025	CDD:464251	2/33 (6%)
		PTKc_ALK_LTK	1113..1389	CDD:270632	86/285 (30%)
		PRK12323	<1407..>1576	CDD:481241