DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and Ddr1

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_001159494.1	Gene:	Ddr1 / 25678	RGDID:	2252	Length:	910	Species:	Rattus norvegicus

Alignment Length:	1017	Identity:	327/1017 - (32%)
Similarity:	479/1017 - (47%)	Gaps:	159/1017 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TLCWLTLTLILLANRFGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASS 126
            ||..|.|.|:|:                 .:|...:........|:.||||:...|.|..|:.||
  Rat     5 TLSSLLLLLLLV-----------------TIGDADMKGHFDPAKCRYALGMQDRTIPDSDISVSS 52

  Fly   127 AHDMGNVGPQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYT 191
            :.. .:...:|:||:..:..|||||...|.....|||||||..:|||:.:.||||...|.|:|::
  Rat    53 SWS-DSTAARHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFS 116

  Fly   192 EAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLR 256
            .:|.:.|.|.| ::|:.|:...|:||:.||.:....|...|.|.:.|..||.||.:....:||||
  Rat   117 RSYRLRYSRDG-RRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLR 180

  Fly   257 AEIVGCAWEEGIVSYSIPKG--MQRGMDIDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNFRAD 319
            .|:.||.|.:|::||:.|.|  ||....:.|:|.|||||..|.....|||||.||..|.|:||..
  Rat   181 VELYGCLWRDGLLSYTAPVGQTMQLSEMVYLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQS 245

  Fly   320 IN-GLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIG- 382
            .. .:..||:::||.|.:.....||:.|||:.:|:...:.:|.|||.:...::....:..|..|
  Rat   246 QELRVWPGYDYVGWSNHSFPSGYVEMEFEFDRLRSFQTMQVHCNNMHTLGARLPGGVECRFKRGP 310

  Fly   383 GRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFT 447
            ...:.||||:.:....|....||.:::.|...:||::|....||..|::.|||:||| .||.:.:
  Rat   311 AMAWEGEPVRHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFIS-DVVNDSS 374

  Fly   448 DELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEP----ETSFVGVIITV 508
            |..      .....:|           .|...:..::..:.|:   .|:|    |.|...::|..
  Rat   375 DTF------PPAPWWP-----------PGPPPTNFSSLELEPR---GQQPVAKAEGSPTAILIGC 419

  Fly   509 LGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSL 573
            |..||:||:..|.|::.| .|.|..   |...:.....:.|..:..:...|.:.:|.....:...
  Rat   420 LVAIILLLLLIIALMLWR-LHWRRL---LSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPP 480

  Fly   574 YHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGT 638
            |.||......|.:|...| |.......:|.|.    ::...||          .||.|.|..|..
  Rat   481 YQEPRPRGTPTHSAPCVP-NGSALLLSNPAYR----LLLATYA----------RPPRGPGPPTPA 530

  Fly   639 GTGP-------GRGSSPEFVVATGKVTASARNSLNAATLPLPSPP-VPPPLEKYYAATPVSSKPM 695
            ...|       |....||                      .|..| :|||        |.:|.|.
  Rat   531 WAKPTNTQACSGDYMEPE----------------------KPGAPLLPPP--------PQNSVPH 565

  Fly   696 PVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADINEERANCQVQEFPRQSLV 760
            ..........|....:|.|......|.||.|.|.                      .:|||..|.
  Rat   566 YAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPR----------------------VDFPRSRLR 608

  Fly   761 IVEKLGSGVFGELHLCET----NVLNA-----------TLVAVATLRPGANDHLRKEFRSKAKQL 810
            ..||||.|.|||:||||.    :::.:           .||||..|||.|..:.|.:|..:.|.:
  Rat   609 FKEKLGEGQFGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATKNARNDFLKEVKIM 673

  Fly   811 AQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAE---TSGLMAKK------SLSF 866
            ::|.|||:.||:|.|::|:|:|::.||.. .|||||||..|..|   |.||...:      ::|:
  Rat   674 SRLKDPNIIRLLGVCVQDDPLCMITDYME-NGDLNQFLSAHQLENKVTQGLPGDRESDQGPTISY 737

  Fly   867 GCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFT 931
            ..|:::..||||||::|..:||||||||||:|::|....:|:...|  ::|:.||.||.:::|
  Rat   738 PMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG--MSRNLYAGDYYRVQG-- 798

  Fly   932 GRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRD 996
               ...:||||||||.:|:|||||.||||:|.|.|||:|...|.||:..|:|:.||||.|..:||
  Rat   799 ---RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRD 860

  Fly   997 YKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYL 1038
            ......|..||.||:.:|:||..||.|:...||.|.::|.:|
  Rat   861 QGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFSQLHRFL 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	60/155 (39%)
		FA58C	109..261	CDD:238014	59/151 (39%)
		PTKc_DDR	753..1040	CDD:270644	133/310 (43%)
		TyrKc	759..1038	CDD:197581	129/302 (43%)
Ddr1	NP_001159494.1	FA58C	58..185	CDD:238014	50/127 (39%)
		DS-like domain. /evidence=ECO:0000250	193..368		62/175 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..494		5/26 (19%)
		PPxY motif	478..481		0/2 (0%)
		PTKc_DDR1	601..904	CDD:133227	133/310 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1844
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1204
OMA	1	1.010	-	-		QHG45751
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm9045
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980