Protein Alignment Ddr and igf1ra

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: XP_073784886.1
• Gene: igf1ra / 245701
• ZFINID: ZDB-GENE-020503-1
• Length: 1433
• Species: Danio rerio
• Alignment Length: 1043
• Identity: 227/1043 - (21%)
• Similarity: 352/1043 - (33%)
• Gaps: 347/1043 - (33%)

  Fly   210 RSLQGKEVLPGNI--------NTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEE 266
            :||||..|:.||:        |..||:|:.:.   ....|..|...::..|
Zfish   375 QSLQGCTVIKGNLQINIRRGNNIASELESFMG---LIQTVTGYVRIKHTHT-------------- 422

  Fly   267 GIVSYSIPKGMQRGMDIDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNFRADINGLGKGYEWIG 331
             :.|.|..|.::..:..:|.|.||..:...:|.:.                         |.| .
Zfish   423 -LGSLSFLKSLRYIVGEELVDNTYAFHAVDNHNLQ-------------------------YLW-D 460

  Fly   332 WRNDTLLGRPVEIIFEF------ETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEP 390
            |....|..:..::.|.|      ..:|.:.........|...||:          ..|...|.|
Zfish   461 WTQHNLTIKTGKLYFRFNPKLCMSEIRKMWEKTSVREKMAEDDVR----------SNGERASCE- 514

  Fly   391 VQFSYMPDLVLDHARDVTIKL---HHRLGRYVQLHLYFAARWMMISEITFI----SAPVVGNFTD 448
               ||:.....:|.:...|||   .:|...|..|             |:||    .||.
Zfish   515 ---SYILKFRSNHTQSTRIKLTWERYRPPDYRDL-------------ISFIVYYKEAPF------ 557

  Fly   449 ELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISP--KPIDHQEPETSFVGVIITVL-- 509
                   |::| |:..|        ...|..|.:...|..|  |.||        .||:::.|
Zfish   558 -------QNIT-EFDGQ--------DGCGSNSWNMVDVDLPQEKSID--------PGVLLSPLKP 598

  Fly   510 GTIIMLLVAFILLIVARNKHV-----------------------RSRENGLDAFQHNFSPDTL-N 550
            .|...:.|..:.|:| .:|||                       |:..|...:....:||... |
Zfish   599 WTQYAIFVKAVTLVV-EDKHVGGAKSEVVYIRTNASAPSMPLDARAYANSSSSLMVKWSPPIAPN 662

  Fly   551 GNGV------------------------LKV-----VTTMDDNESSIDKNSLYHEPFNANMYTSA 586
            ||..                        ||:     .|::.|.|...       :|..:::....
Zfish   663 GNKTFYFLRWQQQAEDGELYQHNYCSKELKIPIRISATSLSDMEGET-------KPTKSDVAGGE 720

  Fly   587 ASACP----MNDLQRQHVSPDYTDV--------------PDI----------------VCQDYAV 617
            ...||    ..||:.:.....|..|              ||.                |.::.:|
Zfish   721 KGCCPCPKTKEDLKAEAEDRSYRKVFENFLHNSIFTPRPPDRKRRDLMGVANSTLVSGVSRNISV 785

  Fly   618 PHMQQLLPNAP----PCGSG------------------------CGTGTGTGPGRGSSPEFVVAT 654
            .......|..|    |...|                        |....    .|.|:..||.:.
Zfish   786 LESNITQPELPEKEYPFSEGKVHTEFMEIHNLRPFTVYRIDIHACNYEV----HRCSAAAFVFSR 846

  Fly   655 GKVTASARNSLNAAT------------LPLPSPPVPPPL--------------EKYYAATPVSSK 693
            .|....|.:...:.|            |..|.|..|..|              ||:...:....|
Zfish   847 TKPADKADDIPGSVTQERDEKGEGIVLLRWPEPLHPNGLILMYEIKYRLGTEAEKHECVSRQQYK 911

  Fly   694 PMPVAPPGSQSSGSLSSSTTAA--------TTPTSGVVGVGKPHH-------------------- 730
            .:..|...:.:||:.|:...|.        |.|.|..|...|.::
Zfish   912 VLRGAQLSNLASGNYSARVRATSLAGNGSWTEPVSFYVPPPKRNYDNAFYVAIIIPVIVLLLLLF 976

  Fly   731 -----------YNLDMSAN---FADINEERAN------CQVQEFPRQSLVIVEKLGSGVFGELH- 774
                       .|.|...|   :|.:|.|..:      ....|..|:.:.:..:||.|.||.::
Zfish   977 VIVAVIIVTKKRNSDRIGNGVLYASVNPEYFSPFEMYVPDEWEVAREKITMCRELGQGSFGMVYE 1041

  Fly   775 -LCETNVLN--ATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQD 836
             :.:..|.:  .|.||:.|:...|:...|.||.::|..:.:.:..:|.||:|...:.:|..::.:
Zfish  1042 GIAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME 1106

  Fly   837 YSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIG 901
            .. ..|||...|:...::..|..::.......::.:|.:||.||.:|....|||||||.|:|::.
Zfish  1107 LM-TRGDLKSHLRSLRSKEQGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA 1170

  Fly   902 PELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVAL 966
            .:..||:...|  :.|..|.:||.: :|..|.    :|:|||:.||:..|.|||.||||||.|.|
Zfish  1171 EDFTVKIGDFG--MTRDIYETDYYR-KGGKGL----LPVRWMSPESLKDGVFTTNSDVWSFGVVL 1228

  Fly   967 WEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSF 1031
            |||.|.| ||||:.:|::.|:       |......||..|.|||..:::||..|||.:...||||
Zfish  1229 WEIATLA-EQPYQGMSNEQVL-------RFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF 1285

  Fly  1032 REI 1034
            .||
Zfish  1286 LEI 1288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	14/58 (24%)
		PTKc_DDR	753..1040	CDD:270644	98/286 (34%)
igf1ra	XP_073784886.1	None