| Sequence 1: | NP_001014474.3 | Gene: | Ddr / 3346209 | FlyBaseID: | FBgn0053531 | Length: | 1054 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_004110.2 | Gene: | FLT3 / 2322 | HGNCID: | 3765 | Length: | 993 | Species: | Homo sapiens |
| Alignment Length: | 363 | Identity: | 106/363 - (29%) |
|---|---|---|---|
| Similarity: | 151/363 - (41%) | Gaps: | 100/363 - (27%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 753 EFPRQSLVIVEKLGSGVFGELHLCETNVLNATL-----------VAVATLRPGANDHLRKEFRSK 806
Fly 807 AKQLAQL-SDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFL---------------QEH---- 851
Fly 852 -----------------------VAETSGLMAK----------------------KSLSFGCLVY 871
Fly 872 IATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQ 936
Fly 937 PMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLS-DKSVIENIGLIYRDYKMH 1000
Fly 1001 ELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYL 1038 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Ddr | NP_001014474.3 | FA58C | 109..261 | CDD:238014 | |
| PTKc_DDR | 753..1040 | CDD:270644 | 106/363 (29%) | ||
| FLT3 | NP_004110.2 | ig | 256..345 | CDD:395002 | |
| Ig strand B | 268..272 | CDD:409448 | |||
| Ig strand C | 282..286 | CDD:409448 | |||
| Ig strand E | 314..317 | CDD:409448 | |||
| Ig strand F | 327..332 | CDD:409448 | |||
| Ig strand G | 340..343 | CDD:409448 | |||
| Protein Kinases, catalytic domain | 572..947 | CDD:473864 | 106/363 (29%) | ||
| Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand | 591..597 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||