Protein Alignment Ddr and EPHB1

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Alignment Length: 794
• Identity: 186/794 - (23%)
• Similarity: 297/794 - (37%)
• Gaps: 242/794 - (30%)

  Fly   447 TDELANGEKQSVTSEYP------LQRDEVGRAISSGGERSQHTTQVISPKPIDHQEPETSF--VG 503
            ||.:...:|.:..||.|      :..||....:..||...:..|:|.|..|:.......:|  .|
Human   117 TDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYG 181

  Fly   504 VIITVLG---------TIIMLLVAF---------ILLIVARNKHVRSRENGLDAFQHNFSPDTL- 549
            ..:::|.         :|:.....|         ..|::||...:.:.|. :|.      |..|
Human   182 ACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEE-VDV------PIKLY 239

  Fly   550 -NGNGVLKV----VTTMD--DNESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYT-- 605
             ||:|...|    .|...  :.|:|:...:.....|.|:......|.||.|.......||..|
Human   240 CNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPICTCR 304

  Fly   606 --------DVPDIVCQDYAVP-----------HMQQLLPNAPPCGSG-------------CGTGT 638
                    |.|::.|.  :||           ....:|...||..:|             |....
Human   305 TGYYRADFDPPEVACT--SVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADR 367

  Fly   639 GTGPGRGSSPEFV-----VATGKVTASAR----------NSLNAATLPLPSPP------------ 676
            .:......:.|||     :...:|:.|:.          .::|..:...|.||
Human   368 RSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQA 432

  Fly   677 VPP--PLEKYYAATPVS---SKPMPVAPPG----------------SQSSGSLSSSTTA------ 714
            .|.  |:....:||..|   |.|.|..|.|                ..||.:.|.:.||
Human   433 APSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLR 497

  Fly   715 ---------------------------------------------ATTPTSGVVGV--------- 725
                                                         |.:..:|||.|
Human   498 PGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIV 562

  Fly   726 --------------GKPHHYNLDMSA----------NFADINEERANCQVQEFPRQ---SLVIVE 763
                          .|..||:....:          .:.|.||     .|:||.::   |.|.:|
Human   563 CSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNE-----AVREFAKEIDVSFVKIE 622

  Fly   764 K-LGSGVFGELHLCETNV--LNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGAC 825
            : :|:|.|||::.....:  .....||:.||:.|.::..|::|.|:|..:.|...||:.||.|..
Human   623 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVV 687

  Fly   826 LRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVH 890
            .:..|:.|:.::.. .|.|:.||:::..:.:.:.         ||.:...||:|||:|.:||:||
Human   688 TKSRPVMIITEFME-NGALDSFLRQNDGQFTVIQ---------LVGMLRGIAAGMKYLAEMNYVH 742

  Fly   891 RDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTT 955
            ||||.|:.::...|..||...|.    |.|..|......:|......:|:||.|.|::...|||:
Human   743 RDLAARNILVNSNLVCKVSDFGL----SRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTS 803

  Fly   956 KSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCEC 1020
            .|||||:.:.:||:::|. |:||..:|::.|   |..|.:||:    ||.|.:||..::.||.:|
Human   804 ASDVWSYGIVMWEVMSFG-ERPYWDMSNQDV---INAIEQDYR----LPPPMDCPAALHQLMLDC 860

  Fly  1021 WQRDESSRPSFREI 1034
            ||:|.:|||.|.||
Human   861 WQKDRNSRPRFAEI 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	98/288 (34%)
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444	17/77 (22%)
		fn3	326..412	CDD:394996	11/85 (13%)
		fn3	435..518	CDD:394996	14/82 (17%)
		EphA2_TM	542..616	CDD:464211	14/78 (18%)
		PTKc_EphR_B	614..882	CDD:173638	96/283 (34%)
		SAM_EPH-B1	908..975	CDD:188950
		PDZ-binding. /evidence=ECO:0000255	982..984