DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ddr and EPHA7

DIOPT Version :10

Sequence 1:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster
Sequence 2:NP_004431.1 Gene:EPHA7 / 2045 HGNCID:3390 Length:998 Species:Homo sapiens


Alignment Length:435 Identity:124/435 - (28%)
Similarity:196/435 - (45%) Gaps:107/435 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   640 TGPGRGS-SPEFVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQ 703
            |..|.|: ||...|||          |..||            .|.:.||.|||:..||      
Human   519 TAAGYGNYSPRLDVAT----------LEEAT------------GKMFEATAVSSEQNPV------ 555

  Fly   704 SSGSLSSSTTAATTPTSG-------VVG--VGKPH----------------HYNLDMSANFADIN 743
                    ...|....:|       |.|  :|:.|                |:....:..:.|..
Human   556 --------IIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPE 612

  Fly   744 E-ERANCQVQEFPRQ---SLVIVEK-LGSGVFGELHLCETNV----LNATLVAVATLRPGANDHL 799
            . |..|..|.:|.::   |.:.:|: :|:|.|||  :|...:    .....||:.||:.|..:..
Human   613 TYEDPNRAVHQFAKELDASCIKIERVIGAGEFGE--VCSGRLKLPGKRDVAVAIKTLKVGYTEKQ 675

  Fly   800 RKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSL 864
            |::|..:|..:.|...|||..|.|...|.:|:.||.::.. .|.|:.||::|..:.:.:.     
Human   676 RRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFME-NGALDAFLRKHDGQFTVIQ----- 734

  Fly   865 SFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIG--TVIN---RSAYASDY 924
                ||.:...||:||::|..|.:||||||.|:.::...|..||...|  .||.   .:.|.:  
Human   735 ----LVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTT-- 793

  Fly   925 CQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIEN 989
                  ||.:   :|:||.|.|::...|||:.|||||:.:.:||::::. |:||..:|::.||:.
Human   794 ------TGGK---IPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYG-ERPYWDMSNQDVIKA 848

  Fly   990 IGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
            |...||       ||.|.:||..::.||.:|||::.:.||.|.:|
Human   849 IEEGYR-------LPAPMDCPAGLHQLMLDCWQKERAERPKFEQI 886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 94/295 (32%)
EPHA7NP_004431.1 EphR_LBD_A7 30..206 CDD:198453
FN3 <314..>539 CDD:442628 9/29 (31%)
FN3 443..534 CDD:238020 6/14 (43%)
EphA2_TM 565..630 CDD:464211 11/64 (17%)
PTKc_EphR_A 628..894 CDD:270651 93/290 (32%)
SAM_EPH-A7 919..988 CDD:188947
PDZ-binding. /evidence=ECO:0000255 996..998
Blue background indicates that the domain is not in the aligned region.

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