Protein Alignment Ddr and EPHA5

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_001268694.1
• Gene: EPHA5 / 2044
• HGNCID: 3389
• Length: 1038
• Species: Homo sapiens
• Alignment Length: 800
• Identity: 171/800 - (21%)
• Similarity: 286/800 - (35%)
• Gaps: 278/800 - (34%)

  Fly   419 VQLHLYFAARWMMISEITFISAPVVGNFTDEL--ANGE--KQSVTSEYPLQRDE--------VGR 471
            |.:.:|:.....::..:......:.|..:.:|  .:|.  ..|||.|.|.....        :|:
Human   224 VSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGK 288

  Fly   472 AISSGG-ERSQHTTQV-----------------ISPKPIDHQEPETSFV---------------- 502
            .:...| |....|.||                 ..|....|:|..||.|
Human   289 CMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMA 353

  Fly   503 ---------GVIITVLGTIIMLL------------VAFILLIVARNK----------HVR--SRE 534
                     ..|..|..|.:.|.            |::.:.....|.          |||  .|:
Human   354 CTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQ 418

  Fly   535 NGL--------DAFQH-NFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASAC 590
            :||        |...| |::.:....|||           |.:...:  .:..:.|:.|:.|:..
Human   419 SGLKNTSVMMVDLLAHTNYTFEIEAVNGV-----------SDLSPGA--RQYVSVNVTTNQAAPS 470

  Fly   591 PMNDLQRQHVSPD-------YTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSP 648
            |:.::::..::.:       ..|.|:.:..:|.:.:.:                      :....
Human   471 PVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFE----------------------KDQET 513

  Fly   649 EFVVATGKVTASARNSLNAATLPLPSPPVPPPLEKY--------------------YAATPVSSK 693
            .:.:...|.|......|..|::             |                    :..||||
Human   514 SYTIIKSKETTITAEGLKPASV-------------YVFQIRARTAAGYGVFSRRFEFETTPVS-- 563

  Fly   694 PMPVAPPGSQS------------------------SGSL-------SSSTTAATTPT-------- 719
               ||....||                        |||.       :||..|...|:
Human   564 ---VAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRASSLCAVAHPSLIWRCGYS 625

  Fly   720 --------------------SGVVGVGKPHHYNLDMSANFADINEERANCQVQEFPRQ---SLVI 761
                                .||.....||.|             |..|..|.||.::   |.:.
Human   626 KAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTY-------------EDPNQAVHEFAKEIEASCIT 677

  Fly   762 VEK-LGSGVFGELHLCETNV----LNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARL 821
            :|: :|:|.|||  :|...:    .....||:.||:.|..:..|::|..:|..:.|...||:..|
Human   678 IERVIGAGEFGE--VCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHL 740

  Fly   822 VGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQM 886
            .|...:.:|:.||.:|.. .|.|:.||:::..:.:.:.         ||.:...|::|||:|..|
Human   741 EGVVTKSKPVMIVTEYME-NGSLDTFLKKNDGQFTVIQ---------LVGMLRGISAGMKYLSDM 795

  Fly   887 NFVHRDLATRSCIIGPELCVKVCSIG--TVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVL 949
            .:||||||.|:.:|...|..||...|  .|:.....|:       :|.|..: :||||.|.|::.
Human   796 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA-------YTTRGGK-IPIRWTAPEAIA 852

  Fly   950 LGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIY 1014
            ..|||:.|||||:.:.:||::::. |:||..::::.||:.:...||       ||.|.:||..:|
Human   853 FRKFTSASDVWSYGIVMWEVVSYG-ERPYWEMTNQDVIKAVEEGYR-------LPSPMDCPAALY 909

  Fly  1015 DLMCECWQRDESSRPSFREI 1034
            .||.:|||::.:|||.|.||
Human   910 QLMLDCWQKERNSRPKFDEI 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	94/291 (32%)
EPHA5	NP_001268694.1	EphR_LBD_A5	60..232	CDD:198451	2/7 (29%)
		FN3	<355..>598	CDD:442628	40/295 (14%)
		FN3	469..559	CDD:238020	9/124 (7%)
		EphA2_TM	576..673	CDD:464211	17/109 (16%)
		PTKc_EphR_A	671..937	CDD:270651	92/286 (32%)
		SAM_EPH-A5	966..1031	CDD:188945