DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ddr and EPHA4

DIOPT Version :10

Sequence 1:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster
Sequence 2:NP_004429.1 Gene:EPHA4 / 2043 HGNCID:3388 Length:986 Species:Homo sapiens


Alignment Length:580 Identity:147/580 - (25%)
Similarity:240/580 - (41%) Gaps:164/580 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   529 HVRSRENGL--------DAFQH-NFSPDTLNGNGVLK--------VVTTMDDNESSIDKNSLYHE 576
            |...::|||        |...| |::.:....|||.|        |..|:..|:::         
Human   385 HYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAA--------- 440

  Fly   577 PFNANMYTSAASACPMNDLQRQHVSPDY--TDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTG 639
                   .|:.:.....::.|..|:..:  .|.|:.|..:|.|.:.::                 
Human   441 -------PSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEK----------------- 481

  Fly   640 TGPGRGSSPEFVVATGKVTASARNS----LNAATLPLPSPPVPPPLEKYY----AATPVS----S 692
               .:......:|.|     :|||:    ||             ||..|.    |.|...    |
Human   482 ---DQNERSYRIVRT-----AARNTDIKGLN-------------PLTSYVFHVRARTAAGYGDFS 525

  Fly   693 KPMPVAP---PGSQSSGSLSSSTTAATTPTSGVVGV-----------------------GKPHHY 731
            :|:.|..   | |:..|..::||....:.:..||.|                       .:..|.
Human   526 EPLEVTTNTVP-SRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHL 589

  Fly   732 NLDMSANFADINEERANCQVQEFPRQ---SLVIVEK-LGSGVFGEL-----------HLCETNVL 781
            |..:.........|..|..|:||.::   |.:.:|| :|.|.|||:           .:|     
Human   590 NQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREIC----- 649

  Fly   782 NATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQ 846
                ||:.||:.|..|..|::|.|:|..:.|...||:..|.|...:.:|:.|:.:|.. .|.|:.
Human   650 ----VAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYME-NGSLDA 709

  Fly   847 FLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSI 911
            ||:::....:.:.         ||.:...|.||||:|..|::||||||.|:.::...|..||...
Human   710 FLRKNDGRFTVIQ---------LVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDF 765

  Fly   912 G--TVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAR 974
            |  .|:.....|:       :|.|..: :||||.|.|::...|||:.|||||:.:.:||::::. 
Human   766 GMSRVLEDDPEAA-------YTTRGGK-IPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYG- 821

  Fly   975 EQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
            |:||..:|::.||:.|...||       ||.|.:||..::.||.:|||::.|.||.|.:|
Human   822 ERPYWDMSNQDVIKAIEEGYR-------LPPPMDCPIALHQLMLDCWQKERSDRPKFGQI 874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 97/299 (32%)
EPHA4NP_004429.1 EphR_LBD_A4 30..203 CDD:198450
FN3 329..436 CDD:238020 13/50 (26%)
FN3 441..532 CDD:238020 23/128 (18%)
EphA2_TM 562..618 CDD:464211 7/55 (13%)
PTKc_EphR_A 616..882 CDD:270651 95/294 (32%)
SAM_EPH-A4 911..981 CDD:188944
PDZ-binding. /evidence=ECO:0000255 984..986
Blue background indicates that the domain is not in the aligned region.

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