DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and Ddr2

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	XP_036018652.1	Gene:	Ddr2 / 18214	MGIID:	1345277	Length:	864	Species:	Mus musculus

Alignment Length:	1009	Identity:	330/1009 - (32%)
Similarity:	467/1009 - (46%)	Gaps:	205/1009 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LTLTLILLANRFGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDM 130
            |.|.|:||.    :|:|               .|::....|:..|||..|.|.|..|||||...
Mouse    19 LVLLLLLLI----LGSA---------------KAQVNPAICRYPLGMSGGHIPDEDITASSQWS- 63

  Fly   131 GNVGPQHARLKIDNNGGAWCPKHMVS-RGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAY 194
            .:...::.||..:...|||||:..|. ..|.|:||:||..:|.::.:.||||...|.|.|:...|
Mouse    64 ESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMY 128

  Fly   195 VIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEI 259
            .|.|.|.| .:||.||:..||:||.||.|.|......|:|.:.|..|||.|.:.:...||:|.|:
Mouse   129 KINYSRDG-SRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVEL 192

  Fly   260 VGCAWEEGIVSYSIPKGMQ----RGMDIDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNF-RAD 319
            .||.|.:|:|||:.|.|.|    .|..|.|:|..||| ..|.....|||||.||..|.|:| :..
Mouse   193 YGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGVSGLDDFTQTH 256

  Fly   320 INGLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGR 384
            ...:..||:::||||::.....:||:|||:.:||.:.:.:|.||||:|.|::|...:.:|.....
Mouse   257 EYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEAS 321

  Fly   385 HFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFTDE 449
            .:....|.|..:.|.|...||.||:.||||:...::...:||..|||.|||||.|...:.|.:..
Mouse   322 EWEPTAVYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGA 386

  Fly   450 LANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEPETSFVGVIITVLGTIIM 514
            |........|.:..|:.|:                               |...::|..|..||.
Mouse   387 LPTSPMAPTTYDPMLKVDD-------------------------------SNTRILIGCLVAIIF 420

  Fly   515 LLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFN 579
            :|:|.|::|:.|....:..|                     |....|.|:|.::..:.    |..
Mouse   421 ILLAIIVIILWRQFWQKMLE---------------------KASRRMLDDEMTVSLSL----PSE 460

  Fly   580 ANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGR 644
            ::|:.:                                                         .|
Mouse   461 SSMFNN---------------------------------------------------------NR 468

  Fly   645 GSSPEFVVATGKVTASARNSLNAATLPL-PSPPVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSL 708
            .|||         :....||......|| |....|..|          .:.:|...||.:.||
Mouse   469 SSSP---------SEQESNSTYDRIFPLRPDYQEPSRL----------IRKLPEFAPGEEESG-- 512

  Fly   709 SSSTTAATTPTSGVVGVGKPHHYNLDMSANFADINEERANC--------------QVQEFPRQSL 759
            .|.......| :|..||  ||:...|: .|...:......|              .|:||||:.|
Mouse   513 CSGVVKPAQP-NGPEGV--PHYAEADI-VNLQGVTGGNTYCVPAVTMDLLSGKDVAVEEFPRKLL 573

  Fly   760 VIVEKLGSGVFGELHLCETNVL---------------NATLVAVATLRPGANDHLRKEFRSKAKQ 809
            ...||||.|.|||:||||...:               ...||||..||..||.:.|.:|..:.|.
Mouse   574 AFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKI 638

  Fly   810 LAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIAT 874
            :::|.|||:.||:..|:.::|:|::.:|.. .|||||||..| ...|...:..::|:..|.::||
Mouse   639 MSRLKDPNIIRLLAVCITEDPLCMITEYME-NGDLNQFLSRH-EPLSSCSSDATVSYANLKFMAT 701

  Fly   875 QIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMP 939
            |||||||:|..:||||||||||:|::|....:|:...|  ::|:.|:.||.:::|     ...:|
Mouse   702 QIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFG--MSRNLYSGDYYRIQG-----RAVLP 759

  Fly   940 IRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLP 1004
            ||||:|||:|||||||.||||:|.|.|||..||.:||||..|||:.||||.|..:||......||
Mouse   760 IRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLP 824

  Fly  1005 MPPNCPREIYDLMCECWQRDESSRPSFREIHLYL 1038
            .|..||..:|.||..||:|:...||||:||||.|
Mouse   825 QPALCPDSVYKLMLSCWRRETKHRPSFQEIHLLL 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	62/156 (40%)
		FA58C	109..261	CDD:238014	61/152 (40%)
		PTKc_DDR	753..1040	CDD:270644	138/301 (46%)
		TyrKc	759..1038	CDD:197581	133/293 (45%)
Ddr2	XP_036018652.1	FA58C	42..194	CDD:238014	61/153 (40%)
Ddr2	XP_036018652.1	PKc_like	567..860	CDD:419665	138/301 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1888
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68505
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1219
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45751
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm8799
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4211
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.000