DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and ddr-2

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_508572.1	Gene:	ddr-2 / 180622	WormBaseID:	WBGene00017381	Length:	797	Species:	Caenorhabditis elegans

Alignment Length:	966	Identity:	282/966 - (29%)
Similarity:	442/966 - (45%)	Gaps:	213/966 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SNGLLAEMPIGTCKQALGMESGAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVSRG 158
            ||.::| :.:..|...|||.:..|.|.||:|||:.|:.:.||||||...::..||||||:.::..
Worm    14 SNTVVA-LELRECSHQLGMSNRKIRDEQISASSSFDLQSTGPQHARAHQESGSGAWCPKNQINSL 77

  Fly   159 LTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNIN 223
            ..|:||:......:::::.|||||..|:|.||..|:.|:||||.|..|..::.....|.:|.|.:
Worm    78 SKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANND 142

  Fly   224 TYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKG-MQRGMDIDLSD 287
            |...:...|..::.|.::|:.|.|...||||:|.|:.||.:::.:|.|::.:| :|.|  |...|
Worm   143 TEHAIRRHLDRAIIARRIRIVPVSNSTRTVCMRVEVFGCPFDDSLVFYNVDQGDLQSG--ISYHD 205

  Fly   288 KTYDG-YEEGDHYVNGLGQLVDGQRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEIIFEFETV 351
            .:||| .....|...|:|:|.||:.||:|...:      .::|:|||...  ...|::.|||..:
Worm   206 FSYDGNLANSPHLTGGIGKLYDGEVGKNNVFVN------HHKWVGWRRKR--NGNVKLAFEFSEL 262

  Fly   352 RNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLG 416
            ||:|.::|||:|.|.|..:.|..|.|.|||.|:.||...|.|:...|...:..|.:.|.:::|:.
Worm   263 RNISGILIHTSNEFKKSAKAFSSATVLFSINGKDFSDTIVHFNNPEDTESEVPRWIRIPVNNRIA 327

  Fly   417 RYVQLHLYFA--ARWMMISEITFISAPVVGNFTD-ELANGEKQSVTSEYPLQRDEVGRAISSGGE 478
            :..::.|.|.  :.|:.|||:.|.|     |.|: ||.|.:
Worm   328 KVAKIRLNFGTDSDWLFISEVNFES-----NHTNIELLNDD------------------------ 363

  Fly   479 RSQHTTQVISPKPI------DHQEPETSFVGVIITVLGTIIMLLVAFILLIVARNKHVRSRENGL 537
                   |:.|..:      :|.:..:.|..:|.    ..:.|:||.|:|.|.    .|.||..:
Worm   364 -------VVIPDSVSYFSVTEHDDGTSMFAFIIF----FFMFLIVAVIILTVL----YRKREYRV 413

  Fly   538 DAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSP 602
            .|    .||   :.|...:::.|       ||.|::.|                       ||||
Worm   414 KA----SSP---SPNAKREILLT-------IDGNTIKH-----------------------HVSP 441

  Fly   603 DYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTASARNSLNA 667
            ....:                                                     ||::|..
Worm   442 STYQM-----------------------------------------------------ARDNLQN 453

  Fly   668 ATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPHHYN 732
            |.  :...|:.|.:..|                 ::...|:.|..||.|....|:.|   |:...
Worm   454 AL--IEKMPMSPIISDY-----------------AEPDISVCSDVTANTPLLYGIDG---PYDTQ 496

  Fly   733 -----LDMSANFADINEERANC-QVQEFPRQSLVIVEKLGSGVFGELHLCETNVLNATLVAVATL 791
                 |.....::|..|  ..| .:.|..|..|:.|.::|.|.|||:.||:   |....|||..|
Worm   497 KRSNPLSSMVKYSDYGE--VYCTTLPEIARDKLICVSRIGQGEFGEVDLCQ---LENRKVAVKKL 556

  Fly   792 RPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQF-LQEHVAET 855
            . |.:......|..:.:.|..|..|||..:||.|...:||..:.:|.. .|||..: |:....:|
Worm   557 H-GISQADEFSFHREIRVLGSLKHPNVVEVVGVCTIQKPILCIMEYME-NGDLKSYILKNPTIQT 619

  Fly   856 SGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAY 920
            |..::           |.||:|:|:.:||..||||||:|.|:|::..|..||:...|  :.||.|
Worm   620 SQCIS-----------ICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFG--MARSLY 671

  Fly   921 ASDYCQLEG-FTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDK 984
            :.:|.::|| |.      :||||||||::|||||:|.||||.|.|.:|||.:...|:||..::|.
Worm   672 SQEYYKVEGKFV------LPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDD 730

  Fly   985 SVIENIGLIYRDYKMHELLPMPPNCPREIY-DLMCECWQRDESSRPSFREIHLYLQ 1039
            .|:||:..:.....:.::|..|..||.::| :.:..||..:.|.||||..:||:||
Worm   731 DVVENLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQ 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	59/155 (38%)
		FA58C	109..261	CDD:238014	58/151 (38%)
		PTKc_DDR	753..1040	CDD:270644	108/290 (37%)
		TyrKc	759..1038	CDD:197581	104/281 (37%)
ddr-2	NP_508572.1	FA58C	24..181	CDD:214572	59/156 (38%)
		FA58C	29..180	CDD:238014	58/150 (39%)
		PKc_like	521..787	CDD:304357	108/290 (37%)
		TyrKc	527..785	CDD:197581	104/281 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166458
Domainoid	1	1.000	105	1.000	Domainoid score	I4168
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68505
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45751
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm4852
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4211
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.790