Protein Alignment Ddr and CSF1R

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_005202.2
• Gene: CSF1R / 1436
• HGNCID: 2433
• Length: 972
• Species: Homo sapiens
• Alignment Length: 360
• Identity: 89/360 - (24%)
• Similarity: 149/360 - (41%)
• Gaps: 93/360 - (25%)

  Fly   753 EFPRQSLVIVEKLGSGVFGELHLCETNVLNATL-----------VAVATLRPGANDHLRKEFRSK 806
            ||||.:|...:.||:|.||:       |:.||.           |||..|:..|:...::...|:
Human   576 EFPRNNLQFGKTLGAGAFGK-------VVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 633

  Fly   807 AKQLAQLSD-PNVARLVGACLRDEPICIVQDYSHCLGDLNQFL---------------------- 848
            .|.::.|.. .|:..|:|||....|:.::.:|. |.|||..||
Human   634 LKIMSHLGQHENIVNLLGACTHGGPVLVITEYC-CYGDLLNFLRRKAEAMLGPSLSPGQDPEGGV 697

  Fly   849 --------QEHVAETSGLMAK-----------------------------KSLSFGCLVYIATQI 876
                    :::|...||..::                             :.|....|::.::|:
Human   698 DYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQV 762

  Fly   877 ASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIR 941
            |.||..|...|.:|||:|.|:.::......|:...|       .|.|......:..:.:..:|::
Human   763 AQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFG-------LARDIMNDSNYIVKGNARLPVK 820

  Fly   942 WMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMP 1006
            |||.||:....:|.:|||||:.:.||||.:... .||..:...|....  |:...|:|.:    |
Human   821 WMAPESIFDCVYTVQSDVWSYGILLWEIFSLGL-NPYPGILVNSKFYK--LVKDGYQMAQ----P 878

  Fly  1007 PNCPREIYDLMCECWQRDESSRPSFREIHLYLQRK 1041
            ...|:.||.:|..||..:.:.||:|::|..:||.:
Human   879 AFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQ 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	88/357 (25%)
CSF1R	NP_005202.2	IG_like	28..85	CDD:214653
		Ig strand B	38..42	CDD:409353
		Ig strand C	55..58	CDD:409353
		Ig strand E	66..71	CDD:409353
		Ig strand F	81..86	CDD:409353
		Ig strand G	94..97	CDD:409353
		IgI_3_CSF-1R	203..295	CDD:409530
		Ig strand A	203..208	CDD:409530
		Ig strand A'	210..216	CDD:409530
		Ig strand B	220..228	CDD:409530
		Ig strand C	234..238	CDD:409530
		Ig strand C'	241..244	CDD:409530
		Ig strand D	248..253	CDD:409530
		Ig strand E	257..265	CDD:409530
		Ig strand F	274..282	CDD:409530
		Ig strand G	285..295	CDD:409530
		IgI_4_SCFR_like	299..400	CDD:409364
		Ig strand A	299..305	CDD:409364
		Ig strand A'	309..314	CDD:409364
		Ig strand B	317..327	CDD:409364
		Ig strand C	331..338	CDD:409364
		Ig strand C'	340..343	CDD:409364
		Ig strand D	347..352	CDD:409364
		Ig strand E	361..370	CDD:409364
		Ig strand F	377..385	CDD:409364
		Ig strand G	388..399	CDD:409364
		Ig_3	401..489	CDD:464046
		Regulatory juxtamembrane domain	542..574
		PTKc_CSF-1R	543..914	CDD:133237	89/360 (25%)
		Activation loop	796..818		3/28 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..950